Effect of Age on Kidney Hyperplasia in the Rat during Cold Acclimation

  • Emma Holečková
  • Marie Baudysova
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 53)


The decreased adaptability of old organisms to different stressing agents is a well known phenomenon, usually considered as one of the main indicators of ageing. Regeneration proceeds at a slower rate, even if the final size of the regenerate may sometimes be the same as in younger individuals. Adaptive growth of the kidney compensating unilateral nephrectomy in rats is inhibited in older individuals (1).


Kidney Cell Cold Acclimation Cold Exposure Kidney Weight Unilateral Nephrectomy 
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  1. 1.
    Soukupova, M., Hnevkovsky, P. and Najbrt, J. Effect of age on kidney hyperplasia in the rat after unilateral nephrectomy. Proceedings of the ECBO Symposium, Impairment of cellular functions during ageing in vivo and in vitro, Plenum Press, in press.Google Scholar
  2. 2.
    Holeckova, E., Baudysova, M. and Michl, J. Effect of cold acclimation on rat kidney growth in vivo and in vitro. Physiol. bohemoslov., in pressGoogle Scholar
  3. 3.
    Holeckova, E. and Baudysova, M. Stimulation of DNA synthesis in rat liver and kidney by cold acclimation. Physiol. bohemoslov., impress.Google Scholar

Copyright information

© Springer Science+Business Media New York 1975

Authors and Affiliations

  • Emma Holečková
    • 1
  • Marie Baudysova
    • 1
  1. 1.Institute of PhysiologyCzechoslovak Academy of SciencesPragueCzech Republic

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