Effect of Age on Kidney Hyperplasia in the Rat after Unilateral Nephrectomy

  • Milena Soukupová
  • Pŕemysl Hněvkovský
  • Jiří Najbrt
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 53)


Adaptive growth of the mammalian, kidney after nephrectomy of the contralateral organ is a firmly established phenomenon. Both increase in cell size and cell number take part in the compensatory growth and the greatest changes appear in kidney cortex. It is not clear, however, whether some ontogenetic differences in renal growth after unilateral nephrectomy exist, as there is evidence pro as well as contra the relation between the age of the individual and the degree and character of kidney growth and restoration of normal function (1–4). Therefore we studied the main characteristics of kidney growth after unilateral nephrectomy in very young, adult and ageing, but not yet senile, rats comparing kidney weight and number of cells obtained from the kidney by trypsinization.


Compensatory Growth Kidney Cortex Kidney Weight Unilateral Nephrectomy Renal Growth 
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Copyright information

© Springer Science+Business Media New York 1975

Authors and Affiliations

  • Milena Soukupová
    • 1
  • Pŕemysl Hněvkovský
    • 1
  • Jiří Najbrt
    • 1
  1. 1.Department of General Biology, Medical FacultyCharles University, and Institute of Clinical and Experimental MedicinePragueCzech Republic

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