The Role of Retinol in, and the Action of Anti-Inflammatory Drugs on, Hereditary Retinal Degeneration

  • A. J. Dewar
  • H. W. Reading
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 53)


Inherited retinal dystrophy in the rat is transmitted by an autosomal recessive gene and blindness occurs after birth as a result of degeneration of the photoreceptor cells (1,2). This resembles the situation in certain forms of inherited retinitis pigmentosa in man. Degeneration of the retina in the strain of albino dystrophic rats known as “Campbells” (1) is associated with an increase in the level of “free” lyric enzymes which appear to originate from lysosomes in the adjacent pigment epithelium (3). It has been suggested (4) that the degeneration of the visual cells is produced by breakdown of lysosomal membranes in pigment epithelium and retina. This breakdown is thought to be due to an abnormal build up of vitamin A alcohol (retinol) in the pigment epithelium which arises from the action of light on an unusually labile type of visual pigment (5).


Acetylsalicylic Acid Lysosomal Enzyme Visual Pigment Retinal Degeneration Retinal Dystrophy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Bourne, M.C., Campbell, D.A. and Tansley, K. 1938. Hereditary degeneration of the rat retina. Brit. J. Ophthal. 22: 613.PubMedCrossRefGoogle Scholar
  2. 2.
    Dowling, J.E. and Sidman, R.L. 1962. Inherited retinal dystrophy in the rat. J, Cell Biol. 14: 73.CrossRefGoogle Scholar
  3. 3.
    Burden, E.M., Yates, C.M., Reading, H.W., Bitensky, L. and Chayen, J. 1971. Investigation into the structural integrity of lysosomes in the normal and dystrophic rat retina. Exp. Eye Res. 12: 159.PubMedCrossRefGoogle Scholar
  4. 4.
    Reading, H.W, 1970. Biochemistry of retinal dystrophy. J Med. Genetics 7: 227.CrossRefGoogle Scholar
  5. 5.
    Reading, H.W, 1966. Retinal and retinol metabolism in hereditary degeneration of the retina. Biochem. J., 100: 34 P.Google Scholar
  6. 6.
    Fell, H,B., Dingle, J.T. and Webb, M. 1962. Studies on the mode of action of excess of Vitamin A. 4: The specificity of the effect on embryonic chick-limb cartilage in culture and on isolated rat liver lysosomes. Biochem. J. 83: 63.PubMedGoogle Scholar
  7. 7.
    Vento, R. and Cacioppo, F. 1973. The effect of retinol on the lysosomal enzymes of bovine retina and pigment epithelium. Exp. Eye Res, 15: 43.PubMedCrossRefGoogle Scholar
  8. 8.
    Yates, C.M., Dewar, A.J., Wilson, H., Winterburn, A.K. and H.W. 1974. Histological and biochemical studies on the retina of a new strain of dystrophic rat. Exp. Eye Res. 18: 119.PubMedCrossRefGoogle Scholar
  9. 9.
    Hess, H.H. and Thalheimer, C. 1965. Microassay of biochemical structure in nervous tissue I: Extraction and partition of lipids and assay of nucleic acids. J. Neurochem. 12: 193.PubMedCrossRefGoogle Scholar
  10. 10.
    Dewar, A.J. and Reading, H,W, 1973® A comparison of RNA metabolism in the visual cortex of sighted rats and rats with retinal degeneration. Exp. Neurol. 40: 216.PubMedCrossRefGoogle Scholar
  11. 11.
    Dewar, A,J., Winterburn, A.K, and ‘Reading, H.W. 1973. RNA metabolism in subcellular fractions from rat cerebral cortex of rats with retinal degeneration. Exp, ‘Neurol. 41: 133PubMedCrossRefGoogle Scholar
  12. Dewar, A.J, and Winterburn, A.K. 1973; Metabolism of nuclear and cytoplasmic proteins in the visual cortex of sighted rats and rats wth retinal degeneration. Exp. Neurol, 41: 584.PubMedCrossRefGoogle Scholar
  13. 13.
    Yates, C.M. 1974® Personal communication.Google Scholar
  14. 14.
    Brunk,;U.T, and Ericsson, J.L.E. 1972. Cytochemical evidence for the leakage of acid phosphatase through ultrastructurally intact lysosomal membranes. Histochemical J. 4: 479.CrossRefGoogle Scholar
  15. 15.
    Chayen, J., Bitensky, L. and Ubhi, G.S. 1972. The experimental modification of lysosomal dysfunction by anti..nflammatory’drugs acting in vitro. Beitr. Path. Bd. 147: 6CrossRefGoogle Scholar
  16. 16.
    Tanaka, K. and Lizuka, Y. 1968. Suppression of enzyme release from isolated rat liver lysosomes by non-steroidal anti-inflammatory drugs. Biochem. Pharmacol, 17: 2023.PubMedCrossRefGoogle Scholar
  17. 17.
    Robinson, D. and Willcox, P. s 1969. Interaction of salicylates with rat liver lysosomes, Biochem. J. 115: 54 P.Google Scholar
  18. 18.
    Powell, E.D.U. and Field, R.A. 1964, Diabetic retinopathy and rheumatoid arthritis. Lancet 2: 17PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1975

Authors and Affiliations

  • A. J. Dewar
    • 1
  • H. W. Reading
    • 1
  1. 1.MRC Brain Metabolism Unit, Department of PharmacologyUniversity of EdinburghUK

Personalised recommendations