Skip to main content
SpringerLink
Log in
Book cover

Cell Impairment in Aging and Development pp 219–233Cite as

Studies on the Proliferative Capacity of Mouse Spleen Cells in Serial Transplantation

  • Chapter

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 53))

Abstract

There are many aspects of cellular ageing which are not yetsolved. Two important problems are whether the phenomenon of limited lifespan in vitro reflects true ageing and whether the limited proliferative capacity of normal, somatic cells in vitro and in vivo is an intrinsic and inevitable process.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Hayflick, L. and Moorhead, P.S. 1961. The serial cultivation of human diploid cell strains. Exp. Cell Res. 25: 585.

    Article  PubMed  CAS  Google Scholar 

  2. Hayflick, L. 1968. Human cells and ageing. Scientific American 218: 32

    Article  PubMed  CAS  Google Scholar 

  3. Martin, G.M., Sprague, C.A. and Epstein, CH. J 1970. Replicative lifespan of cultivated human cells. Laboratory Invest. 23: 86.

    CAS  Google Scholar 

  4. Waters, H. and Walford, R.L. 1970. Latent period for outgrowth of human skin explants as a function of age. Journal of Gerontology 25: 381m

    Article  Google Scholar 

  5. Goldstein, S. 1969. Lifespan of cultured cells in progeriaa` Lancet 1: 424.

    Article  CAS  Google Scholar 

  6. Macieira-Coelho, A., Ponten, J. and Phillipson, L. î966, The division cycle and RNA synthesis in diploid human cells at different passage levels in vitro. Exp. Cell Res. 42: 673.

    Google Scholar 

  7. Pederson, T. and Gelfand, S 1966: Mitosis in regeneration and ageing in relation ro cell division cycle. J. Cell Biol„ 81: 34A.

    Google Scholar 

  8. Simons, J.W.1“:1. 1957. The use of frequency distributions of cell diameters to characterize cell populations in tissue culture,,Exp. Cell Res. 45: 336.

    Google Scholar 

  9. Cristofalo, V.J. 1970® Metabolic aspects of ageing in diploid human cells. Symp. on “Ageing in Cell and Tissue Culture.” Zinkovy, E. Holeckova and VJ. Cristofalo, eds., Plenum Press.

    Google Scholar 

  10. Iacieira-Coelho, A. 1970, The decreased growth potential in vitro of human fibroblasts of adult origin. Symp. On “Ageing in Cell and Tissue Culture.” Zincovy. E.’Holeckova and V. J. Cristofalo, eds., Plenum. Press

    Google Scholar 

  11. Simons, J,W.I,M. 1970. A theoretical and experimental approach to the relationship between cell variability and ageing in vitro. Symp. on “Ageing in Cell and Tissue Culture.” Zinkovy. E. Holeckova and V. J. Cristofalo, eds., Plenum Press.

    Google Scholar 

  12. Lima, L. and Macieira-Coelho, A. 1972. Parameters of ageing in chicken embryo fibroblasts cultivated in vitro. Exp. Cell Res. 70: 279.

    Article  PubMed  CAS  Google Scholar 

  13. Bralow, S.P. and Komarov, S.A. 1962. Parietal cell mass and distribution in stomachs of Wistar rats. Am. J. Physiol. 203: 550.

    PubMed  CAS  Google Scholar 

  14. Covell, W.P. 1926. Quantitative cytological studies on the renaltubules. The Anat. Record, 34: 61

    Google Scholar 

  15. Illing, G. 1905. Vergleichende histologische Untersuchungen uber die Leber der Haussaugetiere. Anat. Anz. 26:177

    Google Scholar 

  16. Chi Ping. 1921.’ On the growth of the largest nerve cells in the superior cervical sympathetic ganglion of the Norway rat. J. Comp. Neur. 33: 281.

    Google Scholar 

  17. Chi Ping. 1921. On the growth of the largest nerve cells in the superior ganglion of the albino rat from birth to maturity. J. Heur. Comp. 33: 313.

    Google Scholar 

  18. Simons,J.W,I.M. and Van Den Broek, C. 1970. Comparison of ageing in vitro and ageing in vivo by means of cell size analysis using a Coulter counter, Gerontologia 16: 340.

    Google Scholar 

  19. Orge’, L,E, 1973. Ageing of clones of mammalian cells. Nature 243: 441

    Google Scholar 

  20. Krohn, P.L. 1962. Review lectures on Senescence. I1. Heterochronic transplantation in the study of aging. Proc. Roy. Sco, B. 157: 128,.

    Google Scholar 

  21. Daniel, C.W. and Young,`L.J:T. 1971. Influence of cell division on an ageing process. Lifespan of mouse mammary epithelium during serial propagation in vivo. Exp. Cell Res. 65: 27.

    Google Scholar 

  22. Cudkowicz, G,, Upton, A,C.,’!Shearer, G.M. and Hughes, W.L. 1964. Lymphocyte content and proliferative capacity of serially transplanted mouse bone marrow. Nature 201: 165.

    Article  PubMed  CAS  Google Scholar 

  23. Siminovitch, L,, Till, J.E. and McCulloch, E.C. 1964. Decline in colony-formation ability of marrow cells subjected to serial transplantation into irradiated mice. J. Cell Comp. Physiol. 64: 23.

    Article  CAS  Google Scholar 

  24. Williamson, A.R. and Askonas, B.A. ‘1972.’ Senescence of an antibody-forming cell clone. Nature 238: 337.

    Google Scholar 

  25. Chen, M.G. 1971.’ Age related changes in hematopoietic stem cell populations of a long-lived hybrid mouse® J. Cell Physiol. 78: 225.

    Google Scholar 

  26. Bekkum, P.W. van and Weyzen, W.W.H. 1961. Repeuplement des tissues irradies. Serial transfer of isologous and homologous hematopoietic cells in irradiated hosts. Path. Biol. 9: 888.

    Google Scholar 

  27. Simons,J.W.I.M. 1970 Characterization of somatic cells by determination of their volumes with a Coulter counter. J. Cell Biol. 46: 610.

    Article  PubMed  CAS  Google Scholar 

  28. Jonge,’H. de. 1963. Inleiding tot de Medische Statistieko Dell I Verhandeling van het Nederlands Instituut voor Preventieve Geneeskunde XLI, p. 301.

    Google Scholar 

  29. Buul, P.P.W.;van. 1973. Comparison of frequencies of radiation-induced stable chromosomal aberrations in somatic and germ tissues of the mouse. Mutation Res. 20: 369.

    Article  PubMed  Google Scholar 

  30. Buul, P.P.W. van. Unpublished data.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Radiation Genetics and Chemical Mutagenesis, University of Leiden, The Netherlands

    J. W. I. M. Simons & C. van den Broek

Authors
  1. J. W. I. M. Simons
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. van den Broek
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania, USA

    Vincent J. Cristofalo

  2. Institute of Physiology, Czechoslovak Academy of Sciences, Budějovická 1083, 142 20, Prague 4, Czechoslovakia

    Emma Holečková

Rights and permissions

Reprints and permissions

Copyright information

© 1975 Springer Science+Business Media New York

About this chapter

Cite this chapter

Simons, J.W.I.M., van den Broek, C. (1975). Studies on the Proliferative Capacity of Mouse Spleen Cells in Serial Transplantation. In: Cristofalo, V.J., Holečková, E. (eds) Cell Impairment in Aging and Development. Advances in Experimental Medicine and Biology, vol 53. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0731-1_18

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-0731-1_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-0733-5

  • Online ISBN: 978-1-4757-0731-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation