Studies on the Proliferative Capacity of Mouse Spleen Cells in Serial Transplantation

  • J. W. I. M. Simons
  • C. van den Broek
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 53)


There are many aspects of cellular ageing which are not yetsolved. Two important problems are whether the phenomenon of limited lifespan in vitro reflects true ageing and whether the limited proliferative capacity of normal, somatic cells in vitro and in vivo is an intrinsic and inevitable process.


Bone Marrow Cell Spleen Cell Mouse Bone Marrow Mouse Spleen Cell Serial Transplantation 
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Copyright information

© Springer Science+Business Media New York 1975

Authors and Affiliations

  • J. W. I. M. Simons
    • 1
  • C. van den Broek
    • 1
  1. 1.Department of Radiation Genetics and Chemical MutagenesisUniversity of LeidenThe Netherlands

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