Changes in Lysosomes during Ageing of Parenchymal and Non-Parenchymal Liver Cells

  • D. L. Knook
  • E. C. Sleyster
  • M. J. van Noord
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 53)


Previous studies at our Institute revealed a decrease in the functional reserve capacity of the rat liver during, ageing (1,2). This reduction in function and other changes occurring in the liver with age (1) will be reflected in metabolic changes at the cellular level. Since the liver consists of different cell types, a Particular ageing phenomenon observed for the intact organ or measured with a liver homogenate may be an expression of a general pattern in all liver cells; alternatively, different cell types may show different patterns.


Acid Phosphatase Parenchymal Cell Kupffer Cell Lysosomal Enzyme Lysosomal Activity 
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Copyright information

© Springer Science+Business Media New York 1975

Authors and Affiliations

  • D. L. Knook
    • 1
  • E. C. Sleyster
    • 1
  • M. J. van Noord
    • 1
  1. 1.Institute for Experimental Gerontology TNO Rijswijk ZHThe Netherlands

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