Abstract
It is a well established phenomenon that animal cells have a finite lifespan in vitro, provided they either are not infected by a virus or keep a normal karyotype. Conversely, abnormal cells survive indefinately (1). Several biochemical parameters have been studied in the past 10 years though very few of those studied have dealt with cell-surface integrity (2). However it is feasible to conceive that modifications of cell surface components would impair cell division since such events have been described for cell differentiation, cell transformation and even for the different phases of the cell cycle (3–5).
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Azencott, R., Hughes, C., Courtois, Y. (1975). Cell Surface Alterations and “in Vitro” Aging of Animal Cells. In: Cristofalo, V.J., Holečková, E. (eds) Cell Impairment in Aging and Development. Advances in Experimental Medicine and Biology, vol 53. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0731-1_11
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DOI: https://doi.org/10.1007/978-1-4757-0731-1_11
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