Cell Surface Alterations and “in Vitro” Aging of Animal Cells

  • R. Azencott
  • C. Hughes
  • Y. Courtois
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 53)


It is a well established phenomenon that animal cells have a finite lifespan in vitro, provided they either are not infected by a virus or keep a normal karyotype. Conversely, abnormal cells survive indefinately (1). Several biochemical parameters have been studied in the past 10 years though very few of those studied have dealt with cell-surface integrity (2). However it is feasible to conceive that modifications of cell surface components would impair cell division since such events have been described for cell differentiation, cell transformation and even for the different phases of the cell cycle (3–5).


Young Cell Trypsin Treatment Chick Embryo Fibroblast Cell Surface Component Chick Embryo Cell 
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Copyright information

© Springer Science+Business Media New York 1975

Authors and Affiliations

  • R. Azencott
    • 1
  • C. Hughes
    • 2
  • Y. Courtois
    • 1
  1. 1.Unité de Recherches Gérontologiques INSERM U. 118ParisFrance
  2. 2.The National Institute for Medical ResearchLondonEngland

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