Identification and Regulation of β-Adrenergic Receptors

  • Robert J. Lefkowitz
Part of the Advances in Experimental Medicine and Biology book series (AEMB)


The receptor concept has been used for some time to explain the striking specificity of hormone and drug effects on tissues. However, it is only within the past few years that a direct experimental approach to the study of these cellular structures has become possible. Since about 1970 radioactively-labeled hormones and drugs have been used with increasing frequency for the purpose of direct identification of a wide variety of receptors for polypeptide hormones and neurotransmitters. By contrast, a variety of technical problems have hindered such direct identification of the membrane-bound adrenergic receptors for catecholamines. Quite recently, these technical problems have been overcome (Lefkowitz, 1975).


Adenylate Cyclase Partial Agonist Scatchard Plot Direct Identification Negative Cooperativity 
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Copyright information

© Springer Science+Business Media New York 1978

Authors and Affiliations

  • Robert J. Lefkowitz
    • 1
  1. 1.Department of Medicine and BiochemistryDuke University Medical CenterDurhamUSA

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