Skip to main content
SpringerLink
Log in

X-Ray Analysis and Circular Dichroism of the Acid Protease from Endothia Parasitica and Chymosin

  • Chapter
  • First Online:
Acid Proteases: Structure, Function, and Biology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 95))

Abstract

Central to the study of mechanism and specificity of the acid proteinases is a knowledge of the three-dimensional structures of enzymes with different physiological roles. The availability of acid proteinases with either extracellular or intracellular roles in vertebrates as well as similar enzymes from plants, protozoa, and fungi allows a wide range of comparative studies. In our laboratory we have undertaken the x-ray analysis of fungal enzymes, those from Endothia parasitica and Mucor pusillus and some vertebrate enzymes including chymosin and chicken pepsin, and are beginning work with cathepsin D.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Hagemeyer, K., Fawwal, I., and Whitaker, J. R. (1968) J. Dairy Sci. 51, 1916–1930

    Article  Google Scholar 

  2. Sardinas, J. L. (1968) Appl. Microbiol. 16, 248–253

    CAS  PubMed  PubMed Central  Google Scholar 

  3. Williams, D. C., Whitaker, J. R., and Caldwell, P. V. (1972) Arch. Biochem. Biophys. 149, 52–61

    Article  CAS  Google Scholar 

  4. Moews, P. C., and Bunn, C. W. (1970) J. Mol. Biol. 54, 395–397

    Article  CAS  Google Scholar 

  5. Jenkins, J. A., Blundell, T. L., Tickle, I. J., and Ungaretti, L. (1975) J. Mol. Biol. 99, 583–590

    Article  CAS  Google Scholar 

  6. Bunn; C. W., Moews, P. C., and Baumber, M. E. (1971) Proc. R. Soc. London, B178, 245–258

    Google Scholar 

  7. Moews, P. C., and Bunn, C. W. (1972) J. Mol. Biol. 68, 389–390

    Article  CAS  Google Scholar 

  8. Green, M. L. (1975) Biochem. J. 151, 763–764

    Article  CAS  Google Scholar 

  9. Tickle, I. J. (1975) Acta Crystallogr. B31, 329–330

    Article  Google Scholar 

  10. North, A. C. T., Phillips, D. C., and Mathews, F. S. (1968) Acta Crystallogr. 24, 351–359

    Article  Google Scholar 

  11. Harding, M. D. (1962) Phil. Thesis, Oxford

    Google Scholar 

  12. Matthews, B. (1965) Acta Crystallogr. 20, 230–239

    Article  Google Scholar 

  13. Singh, A. K., and Ramaseshan, S. (1966) Acta Crystallogr. 21, 279–280

    Article  CAS  Google Scholar 

  14. Dodson, E. E., French, S., and Evans, P. (1975) in Anomalous Scattering (Ramaseshan, S. and Abraham, S. C., eds) pp. 423–426 Munkgaard International Publishers Ltd.

    Google Scholar 

  15. Blundell, T. L., and Johnson, L. N. (1976) Protein Crystallography, Academic Press, London

    Google Scholar 

  16. Dickerson, R. E., Kendrew, J. C., and Strandberg, B. E. (1961) Acta Crystallogr. 14, 1188–1195

    Article  CAS  Google Scholar 

  17. Blow, D. M., and Matthews, B. W. (1973) Acta Crystallogr. 29, 56–62

    Article  CAS  Google Scholar 

  18. Blow, D. M., and Crick, F. C. (1959) Acta Crystallogr. 12, 794–802

    Article  CAS  Google Scholar 

  19. North, A. C. T. (1965) Acta Crystallogr. 18, 212–216

    Article  CAS  Google Scholar 

  20. Subramanian, E., Swan, I. D. A., Liu, M., Davies, D. R., Jenkins, J. A., Tickle, I. J., and Blundell, T. L. PrOc. Natl. Acad. Sci. U.S.A., in press

    Google Scholar 

  21. Perimann, G. E., and Kerwar, G. A. (1973) Arch. Biochem. Biophys. 157, 145–147

    Article  Google Scholar 

  22. Grizzuti, K., and Perimann, G. E. (1969) J. Biol. Chem. 244, 1764–1776

    CAS  PubMed  Google Scholar 

  23. Chen, Y. H., Yang, J. T., and Chau, K. H. (1974) Biochemistry 13, 3350–3359

    Article  CAS  Google Scholar 

  24. Saxena, V. P., and Wetlaufer, D. B. (1971) Proc. Natl. Acad. Sci. U.S.A. 68, 969–972

    Article  CAS  Google Scholar 

  25. Greenfield, N., and Fasman, G. D. (1969) Biochemistry 8, 4108–4115

    Article  CAS  Google Scholar 

  26. Wang, T. T., Dorrington, K. J., and Hofmann, T. (1974) Biochem Biophys. Res. Commun. 57, 865–869

    Article  CAS  Google Scholar 

  27. Sepulveda, P., Marciniszyn, J., Liu, D., and Tang, J. (1975) J. Biol. Chem. 250, 5082–5088

    CAS  PubMed  Google Scholar 

  28. Foltmann, B., and Pedersen, V. B. Private Communication

    Google Scholar 

  29. Crowther, R. A. (1972) in Molecular Replacement Method (Rossmann, M. G. ed) Gordon ana Breacn, New York

    Google Scholar 

Download references

Author information

Author notes

  1. Luciano Ungaretti

    Present address: Centro di Studio per la Crystallografia Strutturale del C. N. R., University of Pavia, Via A. Bassi 4, 27100, Pavia, Italy

  2. Axel Wollmer

    Present address: Abteilung Physiologische Chemie, der medizinischen Fakultat, Rhein — Westf. Techn. Hochschule Aachen, 51 Aachen, Germany

Authors and Affiliations

  1. Laboratory of Molecular Biology, Department of Crystallography Birbeck College, London University, Malet Street, London, WC1E 7HX, UK

    John Jenkins, Ian Tickle, Trevor Sewell, Luciano Ungaretti, Axel Wollmer & Tom Blundell

  2. Laboratory of Biochemistry, School of Biological Sciences Sussex University, Falmer, Brighton, Sussex, UK

    John Jenkins, Ian Tickle, Trevor Sewell, Luciano Ungaretti, Axel Wollmer & Tom Blundell

Authors
  1. John Jenkins
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ian Tickle
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Trevor Sewell
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Luciano Ungaretti
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Axel Wollmer
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Tom Blundell
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Oklahoma Medical Research Foundation, USA

    Jordan Tang

Rights and permissions

Reprints and permissions

Copyright information

© 1977 Springer Science+Business Media New York

About this chapter

Cite this chapter

Jenkins, J., Tickle, I., Sewell, T., Ungaretti, L., Wollmer, A., Blundell, T. (1977). X-Ray Analysis and Circular Dichroism of the Acid Protease from Endothia Parasitica and Chymosin. In: Tang, J. (eds) Acid Proteases: Structure, Function, and Biology. Advances in Experimental Medicine and Biology, vol 95. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-0719-9_4

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-0719-9_4

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4757-0721-2

  • Online ISBN: 978-1-4757-0719-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation