Abstract
An acid protease with an optimum pH of 2.5 was first described in human seminal plasma as pepsin and pepsinogen (1), but had not been purified or characterized. Recently, we have purified the acid protease and its proenzyme from human seminal plasma (2,3). In many respects, the properties of seminal plasma acid protease are similar to those of gastric pepsin. Since the proenzyme is more stable than the active enzyme in alkaline solution and can be converted into its active form in acidic solution, the acid protease is likely to exist in seminal plasma, at the physiological pH around 7.5 (4), in proenzyme form.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Lundquist, F., and Seedorff, H. H. (1952) Nature, 170, 1115–1116
Ruenwongsa, P., and Chulavatnatol, M. (1974) Biochem. Biophys. Res. Commun. 59, 44–50
Ruenwongsa, P., and Chulavatnatol, M. (1975) J. Biol. Chem. 250, 7574–7578
Mann, T. (1964) The Biochemistry of Semen and of the Male Reproductive Tract, pp. 88, Methuen, London
Fox, C. A., Meldrum, S. J., and Watson, B. W. (1973) J. Reprod. Fertil. 33, 69–75
Moghissi, K. S., and Syner, F. N. (1970) Int. J. Fertil. 15, 43–49
Kassell, B., and Meitner, P. A. (1970) Methods Enzymol. 19, 337–347
Weber, K., and Osborn, M. (1969) J. Biol. Chem. 244, 4406–4412
Lowry, 0. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J. (1951) J. Biol. Chem. 193, 265–275
Helga, M., Lang, S. S. J., and Kassell, B. (1971) Biochem. 10, 2296–2301
Chow, R. B., and Kassell, B. (1968) J. Biol. Chem. 243, 1718–1724
Chulavatnatol, M., and Ruenwongsa, P. (1976) Biochim. Biophys. Acta 452, 525–532
Harboe, M., Anderson, P. M., Foltmann, B., Kay, J., and Kassell, B. (1974) J. Biol. Chem. 249, 4487–4494
Foltmann, B., and Andersen, B. (1971) FEBS Lett. 17, 87–89
Mills, J. N., and Tang, J. (1967) J. Biol. Chem. 242, 3093–3097
Zaneveld, L. J. D., Polakoski, K. L., and Schumacher, G. E. B. (1973) J. Biol. Chem. 248, 564–570
Zaneveld, L. J. D., Polakoski, K. L., and Williams, W. L. (1973) Biol. Reprod. 9, 219–225
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1977 Springer Science+Business Media New York
About this chapter
Cite this chapter
Ruenwongsa, P., Chulavatnatol, M. (1977). Acid protease and its Proenzyme from Human Seminal Plasma. In: Tang, J. (eds) Acid Proteases: Structure, Function, and Biology. Advances in Experimental Medicine and Biology, vol 95. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-0719-9_20
Download citation
DOI: https://doi.org/10.1007/978-1-4757-0719-9_20
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4757-0721-2
Online ISBN: 978-1-4757-0719-9
eBook Packages: Springer Book Archive