Pepstatin Inhibition Mechanism

  • Joseph MarciniszynJr.
  • Jean A. Hartsuck
  • Jordan Tang
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 92)


Pepstatin is a strong inhibitor for all acid proteases. It does not inhibit other groups of proteases, such as the neutral and alkaline proteases (1). The unusual potency of pepstatin toward acid proteases is indicated by its Ki which was reported by Kunimoto et al. (2) to be about 1 × 10−10 M for porcine pepsin. Although its chemical structure has been shown (3) to be a hexapeptide which contains two residues of an unusual amino acid, 4-amino-3-hydroxy-6-methylhepatanoic acid (statine), the mode of inhibition by pepstatin is unknown.


Inhibitory Potency Acid Protease Dixon Plot Unusual Amino Acid Porcine Pepsin 
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Copyright information

© Springer Science+Business Media New York 1977

Authors and Affiliations

  • Joseph MarciniszynJr.
    • 1
  • Jean A. Hartsuck
    • 1
  • Jordan Tang
    • 1
  1. 1.Laboratory of Protein Studies Oklahoma Medical Research Foundation, and the Department of Biochemistry and Molecular BiologyUniversity of Oklahoma School of MedicineOklahoma CityUSA

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