Re-Establishment of Terminal Patterns in the Adult Rat Hippocampus by Grafted Monoaminergic Neurons

  • Anders Björklund
  • Ulf Steveni

Abstract

The limbic system, and not least the hippocampus, may belong to those parts of the CNS having a high potential for functional and morphological plastic changes. In the series of experiments reported below we have studied the ability of transplanted monoaminergic — noradrenergic, dopaminergic or serotoninergic — neurons to reinnervate the partially denervated hippocampus.

Keywords

Dentate Gyrus Entorhinal Cortex Dorsal Raphe Nucleus Superior Cervical Ganglion Perforant Path 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. BJÖRKLUND, A., STENEVI, U. and SVENDGAARD, N.-Aa. Growth of transplanted monoaminergic neurons into the adult hippocampus along the perforant path. Nature, 1976, 262, 787–790.PubMedCrossRefGoogle Scholar
  2. BLACKSTAD, T.W. On the termination of some afferents to the hippo- campus and fascia dentata, Acta Anat., 1958, 35, 202–214.PubMedCrossRefGoogle Scholar
  3. BLACKSTAD, T.W. FUXE, K. F HOKFELT, T. Noradrenaline nerve terminals in the hippocampal region of the rat and the guinea pig. Z. Zellforsch., 1967, 78, 463–473.PubMedCrossRefGoogle Scholar
  4. LINDVALL, O. and BARKLUND, A. The organization of the ascending catecholamine neuron systems in the rat brain as revealed by the glyoxylic acid fluorescence method. Acta Physiol— Scand., Suppl. 1974, 412, 1–48.Google Scholar
  5. MOORE, R.Y. Monoamine neurons innervating the hippocampal formation and septum: organization and response to injury. In R.L. Isaacson and K.H. Pribram (Eds.), The Hippocampus, Plenum Press, New York and London, 1975, pp. 215–237Google Scholar
  6. RAISMAN, G., COWAN, W.M. and POWELL, T.P.S. The extrinsic afferent, commissural and association fibres of the hippocampus, Brain, 1965, 88, 963–996.CrossRefGoogle Scholar
  7. STENEVI, U., BARKLUND, A. and SVENDGAARD, N.-Aa. Transplantation of central and peripheral monoamine neurons to the adult rat brain: techniques and conditions for survival, Brain Research, 1976, 114, 1–20.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1978

Authors and Affiliations

  • Anders Björklund
  • Ulf Steveni

There are no affiliations available

Personalised recommendations