Mnemonic Function of the Hippocampus: Correspondence between Animals and Humans

  • Raymond P. Kesner
Part of the Advances in Behavioral Biology book series (ABBI, volume 26)


The purpose of the present paper is to demonstrate that in humans and animals the hippocampus is equivalent in terms of mnemonic function. In both animals and humans it can be shown that disruption of normal hippocampal function results in an impairment of long-term memory (episodic or working memory) for specific events without markedly altering short-term memory or memory for rules (semantic or reference memory). It is suggested that the exact nature of the deficit following hippocampal disruption is an impairment in the encoding of long-term temporal and absolute spatial attributes of specific events. Other attributes (e.g., short-term temporal, emotional) of specific events would be encoded by other neural regions.


Retention Test Hippocampal Lesion Radial Maze Serial Position Curve Hippocampal Damage 
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  1. Atkinson, R. C., and Shiffrin, R. M., 1968, Human memory: A proposed system and its control processes, in: “Advances in the psychology of learning and motivation, research and theory (Vol. 2),” K. W. Spence and J. T. Spence, ed., Academic Press, New York.Google Scholar
  2. Baddeley, A. D., and Warrington, E. K., 1970, Amnesia and the distinction between long-and short-term memory, J. Verb. Learn, and Verb. Behay. 9:176.Google Scholar
  3. Berman, R. F., and Kesner, R. P., 1976, Post-trial hippocampal, amygdaloid, and lateral hypothalamic electrical stimulation: Effects upon memory of an appetitive experience, J. Comp. Phys. Psychol. 90:260.Google Scholar
  4. Bierley, A. R., Kesner, R. P., and Novak, J. M., 1981, Episodic long-term memory in the rat: Time dependent effects of hippocampal stimulation (in preparation).Google Scholar
  5. Bower, G., 1967, A multicomponent theory of the memory trace, in: “Advances in the psychology of learning and motivation (Vol. 1),” K. W. Spence and J. T. Spence, ed., Academic Press, New York.Google Scholar
  6. Butters, N., and Cermak, L., 1975, Some analyses of amnesic syndromes in brain-damaged patients, in: “The hippocampus (Vol. 2),” R. L. Isaacson and K. H. Pribram, ed., Plenum Press, New York.Google Scholar
  7. Cohen, N. J., and Squire, L. R., 1980, Preserved learning and retention of pattern-analyzing skill in amnesia: dissociation of knowing how and knowing that, Science 210: 207.Google Scholar
  8. Craík, F. I. M., and Jacoby, L. L., 1975, A process view of short-term retention, in: “Cognitive theory (Vol. 1),” F. Restle, R. M. Shiffrin, N. J. Castellan, H. R. Lindman, and D. B. Pisoni, ed., Erlbaum, Hillsdale, New Jersey.Google Scholar
  9. Douglas, R. J., 1967, The hippocampus and behavior, Psychol. Bull. 67:416.Google Scholar
  10. Horel, J. A., 1978, The neuroanatomy of amnesia: A critique of the hippocampal memory hypothesis, Brain 101: 403.Google Scholar
  11. Iversen, S. D., 1976, Do hippocampal lesions produce amnesia in animals?, Int. Rev. Neurobiol. 19:1.Google Scholar
  12. Jarrard, L. E., 1975, Role of interference and retention by rats with hippocampal lesions, J. Comp. Phys. Psychol. 89:400.Google Scholar
  13. Kesner, R. P., 1973, A neural system analysis of memory storage and retrieval, Psychol. Bull. 80:177.Google Scholar
  14. Kesner, R. P., 1980, An attribute analysis of memory: The role of the hippocampus, Phys. Psychol. 8:189.Google Scholar
  15. Kesner, R. P. and Conner, H. S., 1974, Effects of electrical stimulation of limbic system and midbrain reticular formation upon short-and long-term memory, Phys. and Behay. 12: 5.Google Scholar
  16. Kesner, R. P. and Novak, J. M., 1981, Memory for lists of items in rats: Role of the hippocampus, Neurosci. Abst. (In Press).Google Scholar
  17. Kinsbourne, M. and Wood, F., 1975, Short-term memory processes and the amnesic syndrome, in: “Short-term memory,” D. Deutsch and J. A. Deutsch, ed., Academic Press, New York.Google Scholar
  18. Milner, B., 1970, Memory and the medial temporal regions of the brain, in: “Biology of memory,” K. H. Pribram and D. E. Broadbent, ed., Academic Press, New York.Google Scholar
  19. Milner, B., 1978, Clues tc the cerebral organization of memory, in: “Cerebral correlates of conscious experience,” P. A. Buser and A. Rougeul-Buser, ed., Elsevier, Amsterdam.Google Scholar
  20. Mishkin, M., 1978, Memory in monkeys severely impaired by combined but not by separate removal of amygdala and hippocampus, Nature 273: 297.PubMedGoogle Scholar
  21. O’Keefe, J. and Nadel, L., 1978, “The hippocampus as a cognitive map,” Clarendon Press, Oxford.Google Scholar
  22. Olton, D. S., Becker, J. T., and Handelmann, G. E., 1980, Hippo-campal function: Working memory or cognitive mapping?, Phys. Psychol. 8:239.Google Scholar
  23. Shiffrin, R. M. and Schneider, W., 1977, Controlled and automatic human information processing: II. Perceptual learning, automatic attending, and a general theory, Psych. Rev. 84:127.Google Scholar
  24. Spear, N. F., 1976, Retrieval of memories: A psychobiological approach, in: “Handbook of learning and cognitive processes (Vol. 4),” W. K. Estes, ed., Erlbaum, Hillsdale, New Jersey.Google Scholar
  25. Tulving, E., 1972, Episodic and semantic memory, in: “Organization of memory,” E. Tulving and W. Donaldson, ed., Academic Press, New York.Google Scholar
  26. Underwood, B. J., 1969, Attributes of memory, Psych. Rev. 76:559. Warrington, E. K., 1971, Neurological disorders of memory, Brit. Med. Bull. 27:243.Google Scholar
  27. Weiskrantz, L., 1978, A comparison of hippocampal pathology in man and other animals, in: “Functions of the septo-hippocampal system,” Elsevier, Amsterdam.Google Scholar
  28. Weiskrantz, L. and Warrington, E. K., 1979, Conditioning in amnesic patients, Neuropsychol. 17: 187.CrossRefGoogle Scholar
  29. Welker, W. I., 1976, Brain evoluation in mammals. A review of concepts, problems, and methods, in: “Evolution of brain and behavior in vertebrates,” R. B. Masteron, M. E. Bitterman, B. Campbell, and N. Hutton, ed., Erlbaum, Potomac, Maryland.Google Scholar
  30. Wickelgren, W. A., 1979, Chunking and consolidation: A theoretical synthesis of semantic networks, configuring in conditioning, S-R versus cognitive learning, normal forgetting, the amnesic syndrome, and the hippocampal arousal system, Psych. Rev. 86:44.Google Scholar
  31. Wickens, D. P., 1972, Characteristics of word encoding, in: “Coding processes in human memory,” A. W. Melton and E. Martin, ed., V. H. Winston, Washington, D.C.Google Scholar
  32. Winocur, G. and Olds, J., 1978, Effects of context manipulation on memory and reversal learning in rats with hippocampal lesions J. Comp. Phys. Psychol. 92:312.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1982

Authors and Affiliations

  • Raymond P. Kesner
    • 1
  1. 1.Department of PsychologyUniversity of UtahSalt Lake CityUSA

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