Conditioning pp 131-145 | Cite as

Activity of Dentate Gyrus During NM Conditioning in Rabbit

  • Donald J. Weisz
  • Gregory A. Clark
  • Bo-yi Yang
  • Richard F. Thompson
  • Paul R. Solomon
Part of the Advances in Behavioral Biology book series (ABBI, volume 26)


Two studies were conducted to characterize the role of dentate gyrus during classical conditioning of the rabbit nictitating membrane response. In the first study, dentate field potentials elicited by perforant path stimulation were recorded before and during training to test for changes in granule cell excitability. Results showed above-baseline increases in population spike amplitude over the course of training in paired but not unpaired animals. In a second study, the activity of identified single granule cells was recorded during conditioning to determine if they exhibited the same neuronal response patterns seen in hippocampal pyramidal cells and in entorhinal cortex. Unlike responses in these other areas, granule cell responses did not develop a model of the behavioral response; instead they were tied more to stimulus presentation, with many cells exhibiting stimulus-evoked thetafrequency bursting in paired but not in unpaired animals. Taken together these studies suggest an intimate involvement of the dentate gyrus in the associative process; however dentate’s role appears to be different from that of other hippocampal regions.


Conditioned Stimulus Granule Cell Dentate Gyrus Entorhinal Cortex Nictitate Membrane 
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  1. 1.
    T. W. Berger and R. F. Thompson, 1978, Neuronal plasticity in the limbic system during classical conditioning of the rabbit nictitating membrane response. I. The hippocampus, Br. Res., 145: 323.Google Scholar
  2. 2.
    T. W. Berger and R. F. Thompson, 1978, Identification of pyramidal cells as the critical elements in hippocampal neuronal plasticity during learning, PNAS, 75: 1572.PubMedCrossRefGoogle Scholar
  3. 3.
    T. W. Berger and R. F. Thompson, 1978, Neuronal plasticity in the limbic system during classical conditioning of the rabbit nictitating membrane. II. Septum and mammillary bodies, Br. Res., 156: 293.Google Scholar
  4. 4.
    G. A. Clark, T. W. Berger, and R. F. Thompson, 1978, The role of entorhinal cortex during classical conditioning: Evidence for entorhinal-dentate facilitation, Neurosci. Abstr., 4: 673.Google Scholar
  5. 5.
    M. Segal, J. F. Disterhoft, and J. Olds, 1972, Hippocampal unit activity during classical aversive and appetitive conditioning, Sci., 175: 792.CrossRefGoogle Scholar
  6. 6.
    M. Segal and J. Olds, 1973, Activity of units in the hippocampal circuit of the rat during differential classical conditioning, J. comp. physiol. Psychol., 82: 195.PubMedCrossRefGoogle Scholar
  7. 7.
    G. Rose, 1980, Physiological analysis of the hippocampus during behavior, Doctoral dissertation presented to University of California, Irvine.Google Scholar
  8. 8.
    M. Segal, 1973, Flow of conditioned responses in limbic telencephalic system of the rat, J. Neurophys., 36: 840.Google Scholar
  9. 9.
    S. A. Deadwyler, M. West, and G. Lynch, 1979, Activity of dentate granule cells during learning: Differentiation of perforant path input, Br. Res., 169: 29.Google Scholar
  10. 10.
    J. Winson, 1980, Influence of raphe nuclei on neuronal transmission from perforant pathway through dentate gyrus, J. Neurophysiol., 44: 937.PubMedGoogle Scholar
  11. 11.
    J. Winson and C. Abzug, 1978, Dependence upon behavior of neuronal transmission from perforant pathway through entorhinal cortex, Br. Res., 147: 422.Google Scholar
  12. 12.
    M. Radulovacki and W. R. Adey, 1965, The hippocampus and the orienting reflex, Exp. Neurol., 12: 68.PubMedCrossRefGoogle Scholar
  13. 13.
    G. Busaki, E. Grastyan, I. N. Tveritskaya and J. Czopf, 1979, Hippocampal evoked potentials and EEG changes during classical conditioning in the rat, Electroenceph. clin. Neurophysiol., 47: 64.Google Scholar
  14. 14.
    S. Vinogradova, Functional organization of the limbic system in the process of registration of information: Facts and hypotheses. in: “The Hippocampus,” R. L. Isaacson and K. H. Pribram, ed., Plenum Press, New York (1975).Google Scholar
  15. 15.
    L. E. Mays and P. J. Best, 1975, Hippocampal unit activity to tonal stimuli during arousal from sleep and in awake rats, Exp. Neur., 47: 268.CrossRefGoogle Scholar
  16. 16.
    T. I. Lidsky, M. S. Levine, and S. MacGregor, 1974, Hippocampal units during orienting and arousal in rabbits, Exp. Neur., 44: 171.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1982

Authors and Affiliations

  • Donald J. Weisz
    • 1
  • Gregory A. Clark
    • 2
  • Bo-yi Yang
    • 2
  • Richard F. Thompson
    • 2
  • Paul R. Solomon
    • 3
  1. 1.Dept. of PsychologyYale UniversityUSA
  2. 2.Dept. of PsychologyStanford UniversityUSA
  3. 3.Dept. of PsychologyWilliams CollegeUSA

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