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The Mobile Receptor Hypothesis: A Global View

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The Mobile Receptor Hypothesis

Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

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Abstract

This chapter attempts to put the findings of the previous seven chapters into a wider context and to expand on the implications of the Mobile Receptor Hypothesis. As we have seen in the last three chapters, receptor movement, as well as the “reverse side of the coin,” receptor immobilization, plays a central role in signaling at the level of the membrane in a variety of signal transduction and receptor systems1,2 and thereby in the regulation of cellular processes such as immune responses, differentiation/transformation, cell proliferation/ death, growth, metabolism and motility/metastasis. From a variety of observations in the previous chapters, and in chapters 6 and 7 in particular, it should be clear that there is a body of evidence for the role of the cytoskeleton in modulating membrane protein lateral mobility as well as for the ability of signaling pathways to interact with and regulate other signal transduction cascades through modulation of the lateral mobilities of heterologous membrane components. Both of these aspects will be discussed in some detail below, with the conclusion that signal transduction pathways are able to modulate the lateral movement of heterologous membrane proteins and receptors largely through regulating their respective membrane skeletal/cytoskeletal linkages. Possible pharmacological applications of knowledge of the factors regulating lateral mobility will be discussed in section E.

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    David A. Jans

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Jans, D.A. (1997). The Mobile Receptor Hypothesis: A Global View. In: The Mobile Receptor Hypothesis. Molecular Biology Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0680-2_8

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