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Introduction to the Mobile Receptor Hypothesis

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The Mobile Receptor Hypothesis

Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

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Abstract

The idea that proteins float freely within the lipid bilayer of biological membranes gained initial impetus through the formulation of the “fluid mosaic” model in the early 1970s.1 Based on electron microscopy and freeze-fracture analysis as well as a number of other studies, the structure of biological membranes was purported to be and is still believed to be as shown in Figure 1.1: “dissolved” proteins float within the “sea” of membrane lipid. This includes integral membrane proteins, that is, proteins that completely traverse the lipid bilayer sometimes more than once such as membrane receptors, as well as peripheral membrane proteins such as the guanosine-triphosphate (GTP) binding protein (“G-protein”) subunits and cell-cell recognition molecules such as LFA-2 (lymphocyte function-associated antigen-2), which are only associated with the membrane and do not traverse it. They are linked to the lipid bilayer through a variety of covalent modifications, such as glycosyl phosphatidylinositol anchors, myristoyl and palmitoyl fatty acid linkages, etc.

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Authors and Affiliations

  1. John Curtin School of Medical Research, Australian National University, Canberra, Australia

    David A. Jans

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© 1997 R.G. Landes Company

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Jans, D.A. (1997). Introduction to the Mobile Receptor Hypothesis. In: The Mobile Receptor Hypothesis. Molecular Biology Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0680-2_1

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  • DOI: https://doi.org/10.1007/978-1-4757-0680-2_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-0682-6

  • Online ISBN: 978-1-4757-0680-2

  • eBook Packages: Springer Book Archive

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