Influence of Ferrous Ions on CCl4-Induced Lipid Peroxidation

  • H. Kappus
  • H. Kieczka
  • H. Muliawan
  • R. M. Schulze
  • H. Ottenwälder
Part of the Advances in Experimental Medicine and Biology book series (AEMB)


Many toxic chemicals, including CC14, induce the formation of lipid peroxides in the liver (Plaa and Witschi, 1976; Tappel, 1980). Lipid peroxidation, therefore, might be one of the mechanisms involved in their toxicity. However, the direct measurement of lipid peroxides, the primary candidates for toxic reactions, cannot be quantitatively determined either in vitro or in vivo. Only decomposition products of lipid peroxides are measurable, such as malondialdehyde or alkanes (for review see Tappel, 1980). Furthermore, it has been assumed that the decomposition products of lipid peroxides induced by CC14 are the toxic intermediates, rather than the lipid peroxide itself (Mead, 1976; Miguel, 1977; Recknagel et al., 1977; Gardner, 1979). Dialyzable and extractable cytotoxic products occurring during lipid peroxidation have been described recently by several authors (Roders et al., 1978; Willis et al., 1979; Benedetti et al., 1979a,b,1980; Schulze and Kappus, 1980).


Lipid Peroxidation Barbituric Acid Induce Lipid Peroxidation Hepatic Microsome Microsomal Incubation 
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Copyright information

© Springer Science+Business Media New York 1982

Authors and Affiliations

  • H. Kappus
    • 1
  • H. Kieczka
    • 2
  • H. Muliawan
    • 1
  • R. M. Schulze
    • 1
  • H. Ottenwälder
    • 1
  1. 1.Section on Pharmacology, Med. Institute of Environmental HygieneUniversity of DüsseldorfDüsseldorf 1Germany
  2. 2.Institute of ToxicologyUniversity of TübingenTübingen 1Germany

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