Abstract
Carbontetrachloride (CCl4) is hepatotoxic and has also been shown to produce liver tumours in several rodent species (Andervont, 1958; Edwars, 1941; Edwars and Dalton, 1942; Edwars et al., 1942; Reuber, 1970; Reuber and Gloves, 1970). It is virtually certain that these effects are due to the generation of reactive intermediates from the parent compound in liver microsomes. CC14-inter-mediates have been shown to bind irreversibly to hepatocellular proteins and lipids (Reynolds, 1967; Recknagel, 1967), the latter effect leading to lipid peroxidation (Glende, 1972).
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© 1982 Springer Science+Business Media New York
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Kitta, D., Schwarz, M., Tennekes, H.A., Uehleke, H., Kunz, W. (1982). Covalent Binding of CCl4-Intermediates to Reduced Pyridine Nucleotides in Mouse Liver. In: Snyder, R., et al. Biological Reactive Intermediates—II. Advances in Experimental Medicine and Biology, vol 136. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-0674-1_59
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DOI: https://doi.org/10.1007/978-1-4757-0674-1_59
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