Metabolic Activation of Bromopropyl Compounds

  • Erik Dybing
  • Erik J. Söderlund
  • Sidney D. Nelson
Part of the Advances in Experimental Medicine and Biology book series (AEMB)


The possible health risks involved with the use of flame retardants were recognized when it was shown that tris(2,3-dibromopropyl)phosphate (Tris-BP), the major chemical used in US sleepwear between 1973 and 1977, was a potent mutagen in the Salmonella test1,2. It was subsequently demonstrated that Tris-BP caused kidney tubular adenomas and carcinomas in long-term feeding experiments in rats and mice3. This flame retardant can be absorbed from fabric worn by people, because one of its hydrolysis products, 2,3-dibromopropanol (2,3-DBP), wad excreted in the urine of children wearing Tris-BP treated garments4.


Flame Retardant Covalent Binding Kidney Toxicity Diethyl Maleate Cobaltous Chloride 
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Copyright information

© Springer Science+Business Media New York 1982

Authors and Affiliations

  • Erik Dybing
    • 1
  • Erik J. Söderlund
    • 1
  • Sidney D. Nelson
    • 1
  1. 1.Department of Toxicology, National Institute of Public Health, Oslo, Norway and Department of Medicinal ChemistryUniversity of WashingtonSeattleUSA

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