Effect of 2-Propanol Treatment on Carbon Tetrachloride Metabolism and Toxicity
The potentiation of carbon tetrachloride (CC14) hepatotoxicity by acute alcohol administration is well known (Cornish and Adefuin, 1967; Strubelt, 1980) although the mechanism of this potentiation is unclear. Carbon tetrachloride must undergo metabolism in order to produce tissue damage (Recknagel and Glende, 1973). Several authors have suggested that increased bioactivation is involved in the alcohol potentiation of CC14 hepatotoxicity (Cote et al., 1974; Maling et al., 1975; Sipes et al., 1973; Strubelt et al., 1978; Traiger and Plaa, 1973) but the evidence on this point is largely indirect.
KeywordsLipid Peroxidation Carbon Tetrachloride Carbon Tetra Phenobarbital Treatment Hepatic Microsomal Cytochrome
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