Metabolic Activation of Adriamycin by Nadph-Cytochrome P-450 Reductase, Rat Liver and Heart Microsomes and Covalent Protein Binding of Metabolites

  • Max E. Scheulen
  • Hermann Kappus
Part of the Advances in Experimental Medicine and Biology book series (AEMB)


The anthracycline antibiotic adriamycin is a highly effective anticancer chemotherapeutic agent (Blum and Carter, 1974). Its clinical use is limited to a total dose of 550 mg/sq m body surface by cumulative cardiotoxicity (Lefrak et al., 1973). As there is no reliable in vitro-test system for the cardiotoxicity of new anthracyclines pathological and electrocardiographical evaluations in mouse, rat, and rabbit are mainly used (Zbinden and Brändle, 1975; Mettler et al., 1977).


Covalent Binding Microsomal Protein Anthracycline Antibiotic Microsomal Electron Transport Adriamycin Cardiotoxicity 
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Copyright information

© Springer Science+Business Media New York 1982

Authors and Affiliations

  • Max E. Scheulen
    • 1
  • Hermann Kappus
    • 2
  1. 1.Innere Klinik und Poliklinik (Tumorforschung),Westdeutsches TumorzentrumUniversität EssenEssen 1Germany
  2. 2.Abteilung für PharmakologieMedizinisches Institut für UmwelthygieneUniversität DüsseldorfDüsseldorfGermany

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