Abstract
1,3-Butadiene is a major industrial chemical used in the production of synthetic elastomers such as polybutadiene and styrene-butadiene rubber (SBR). Like most of the unsaturated olefins, butadiene is metabolized in vivo. The first step of its biotransformation is the cytochrome P-450-dependent epoxidation to butadiene monoxide (Malvoisin et al, 1979). Both butadiene and butadiene monoxide have been shown to be mutagenic in the Ames test (de Meester et al, 1978).
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© 1982 Springer Science+Business Media New York
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Malvoisin, E., Mercier, M., Roberfroid, M. (1982). Enzymatic Hydration of Butadiene Monoxide and Its Importance in the Metabolism of Butadiene. In: Snyder, R., et al. Biological Reactive Intermediates—II. Advances in Experimental Medicine and Biology, vol 136. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-0674-1_32
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DOI: https://doi.org/10.1007/978-1-4757-0674-1_32
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