Role of Mixed-Function Oxidases in the Formation of Biological Reactive Intermediates

  • Dennis V. Parke
  • Costas Ioannides
Part of the Advances in Experimental Medicine and Biology book series (AEMB)

Abstract

It is now well-known that many toxic chemicals are converted into reactive intermediates by the action of the microsomal mixed-function oxidases. This enzyme system, which comprises cytochromes P-450 and cytochrome P-450 reductase, is a ubiquitous system found in every living organism which has been investigated, including bacteria, yeasts and flowering plants. The system varies with the type of living organism, with its stage of development, and with the tissue in which the mixed-function oxidase is located; it may be found in the cytoplasm (bacteria), the endoplasmic reticulum (yeast), and the endoplasmic reticulum or mitochondria (mammals) (Hodgson, 1979 see Figure 1). It is perhaps of significance that in the transition from the unicellular bacteria to the multicellular organisation of yeasts, cytochrome P-450 is transferred from the cytoplasm to the endoplasmic reticulum (Wiseman, et al, 1978), where, as with higher organisms, it may be involved in the multicellular organ izat ion.

Keywords

Endoplasmic Reticulum Reactive Intermediate Chemical Carcinogen Body Mass Ratio Oxygen Insertion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1982

Authors and Affiliations

  • Dennis V. Parke
    • 1
  • Costas Ioannides
    • 1
  1. 1.Department of BiochemistryUniversity of Surrey GuildfordSurreyEngland

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