Multi-Step Metabolic Activation of Benzene in Rat Liver Microsomes

  • Anders Tunek
  • Franz Oesch
Part of the Advances in Experimental Medicine and Biology book series (AEMB)


Benzene is a ubiquitous component of our chemical age. Due to its very special chemical and physical properties, benzene is widely used in the chemical industry and in the manufacture of rubber and plastics. In addition, benzene is used in motor fuel as an anti-knocking agent (Berlin et al., 1974).


Covalent Binding Mercapturic Acid Microsomal Incubation Benzene Metabolite Field Desorption Mass Spectrometry 
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Copyright information

© Springer Science+Business Media New York 1982

Authors and Affiliations

  • Anders Tunek
    • 1
    • 2
  • Franz Oesch
    • 2
    • 2
  1. 1.Institute of Environmental HealthUniversity of LundLundSweden
  2. 2.Section on Biochemical PharmacologyInstitute of Pharmacology, UniversityMainzWest-Germany

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