Alkylation and Peroxidation Injury from Chemically Reactive Metabolites

  • J. R. Mitchell
  • G. B. Corcoran
  • C. V. Smith
  • H. Hughes
  • B. H. Lauterburg
Part of the Advances in Experimental Medicine and Biology book series (AEMB)


As initiators of chemical-induced tissue injury, alkylation and peroxidation reactions are often discussed as though they were mutually exclusive or competing adversaries for our love and affection, our hearts and souls. They are neither mutually exclusive nor competing hypotheses. In fact for some chemicals converted to radical metabolites, they might even be additive.


Covalent Binding Lipid Hydroperoxide Hydroxy Fatty Acid Diene Conjugation Hepatic Necrosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1982

Authors and Affiliations

  • J. R. Mitchell
    • 1
  • G. B. Corcoran
    • 1
  • C. V. Smith
    • 1
  • H. Hughes
    • 1
  • B. H. Lauterburg
    • 1
  1. 1.Department of Medicine and Institute for Lipid ResearchBaylor College of MedicineHoustonUSA

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