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Hyocholic Acid and Muricholic Acids

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Book cover The Bile Acids Chemistry, Physiology, and Metabolism

Abstract

The occurrence of a species-specific bile acid in pig bile [Haslewood (1); Haslewood and Sjövall (2)] and of two such acids in rat bile [Bergstrom and Sjövall (3); Hsia et al. (4); Matschiner et al. (5)] was observed almost simultaneously. After their isolation and characterization, these acids were found to be isomeric 3α,6,7-trihydroxy-5β-cholanic acids. The acid from pig bile was named hyocholic acid [Haslewood (6); Ziegler (7)], and the two acids from rat bile were named α- and β-muricholic acids [Hsia et al. (8)]. The fourth isomer of these glycols was identified as a metabolite of hyodeoxycholic acid (3α,6α-dihydroxy-5β-cholanic acid) in the rat [Matschiner et al. (9, 10)], and was named ω-muricholic acid [Hsia et al. (8)]. The vicinal glycol structures in ring B of these acids are unique features, but even more unique are their species-specific characteristics which are particularly demonstrated in the metabolic pathways that lead to their formation.

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Author information

Authors and Affiliations

  1. University of Miami School of Medicine, Miami, Florida, USA

    S. L. Hsia

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  1. S. L. Hsia
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Editors and Affiliations

  1. Biochemistry Research Division Department of Medicine, Sinai Hospital of Baltimore, Inc., Baltimore, Maryland, USA

    Padmanabhan P. Nair

  2. The Wistar Institute, Philadelphia, Pennsylvania, USA

    David Kritchevsky

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© 1971 Springer Science+Business Media New York

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Hsia, S.L. (1971). Hyocholic Acid and Muricholic Acids. In: Nair, P.P., Kritchevsky, D. (eds) The Bile Acids Chemistry, Physiology, and Metabolism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0647-5_4

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  • DOI: https://doi.org/10.1007/978-1-4757-0647-5_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-0649-9

  • Online ISBN: 978-1-4757-0647-5

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