Advertisement

Slow Wave Sleep and Carry-over of Functional Tolerance and Physical Dependence in Alcoholics

  • Milton M. Gross
  • John M. Hastey
  • Eastlyn Lewis
  • Norma Young
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 59)

Abstract

Alcohol affects sleep. In alcoholics, profound sleep changes have been observed clinically and experimentally before, during and after a period of heavy alcohol intake. Elucidation of the alcohol-sleep interactions may illuminate mechanisms involved in alcoholism. This communication will focus on the post-drinking Slow Wave Sleep (SWS) which tends to be decreased initially and gradually recovers. More specifically the post-drinking SWS will be examined in relation to the rate of reacquisition of functional tolerance and physical dependence in a subsequent drinking episode.

Keywords

Total Sleep Time Slow Wave Sleep Withdrawal Syndrome Alcohol Intoxication Physical Dependence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Allen, R.P., Wagman, A., Faillace, L.A. and McIntosh, M., 1971. Electroencephalographic (EEG) sleep recovery following prolonged alcohol intoxication in alcoholics. J. Nerv. and Ment. Dis. 153:424–433.Google Scholar
  2. Branchey, M., Rauscher, G. and Kissin, B., 1971. Modifications in the response to alcohol following the establishment of physical dependence. Psychopharmacologia 22: 314–322.Google Scholar
  3. Feinberg, I., Wender, P.A., Koresko, R.L., Gottlieb, F. and Piehuta, J.A., 1969. Differential effects of chlorpromazine and phenobarbital on EEG sleep patterns. J. Psychiat. Res. 7:101–109.Google Scholar
  4. Gross, M.M., Goodenough, D.R., Tobin, M., Halpert, E., Lepore, D., Perlstein, A., Sirota, M., DiBianco, J., Fuller, R. and Kishner, I., 1966. Sleep disturbances and hallucinations in the acute alcoholic psychoses. J. Nerv. and Ment. Dis. 142: 493–514.Google Scholar
  5. Gross, M.M. and Goodenough, D.R., 1968. Sleep disturbances in the acute alcoholic psychoses. In: Psychiatric Research Report 24, pp. 1. 32–147, American Psychiatric Association, New York.Google Scholar
  6. Gross, M.M., Goodenough, D.R., Hastey, J.M., Rosenblatt, S.M. and Lewis, E., 1971a. Sleep disturbances in alcohol intoxication and withdrawal. In: (Eds.) N.K. Mello and J.H. Mendelson, Recent Advances in Studies of Alcoholism pp. 317–397, U.S. Government Printing Office, Washington, D.C.Google Scholar
  7. Gross, M.M., Rosenblatt, S.M., Malenowski, B., Braman, M. and Lewis, E., 1971b. A factor analytic study of the clinical phenomena in the acute alcohol withdrawal syndromes. Alkohologia 2: 1–7.Google Scholar
  8. Gross, M.M., Lewis, E. and Nagarajan, M., 1973a. An improved quantitative system for assessing the acute alcoholic psychoses and related states (TSA and SSA). In: (Ed.) M.M. Gross, Alcohol Intoxication and Withdrawal: Experimental Studies Advances in Experimental Medicine and Biology, Vol. 35, pp. 365–376, Plenum Press, New York.Google Scholar
  9. Gross, M.M., Goodenough, D.R., Nagarajan, M. and Hastey, J.M., 1973b. Sleep changes induced by 4 and 6 days of experimental alcoholization and withdrawal in humans. In: (Ed.) M.M. Gross, Alcohol Intoxication and Withdrawal: Experimental Studies Advances in Experimental Medicine and Biology, Vol. 35, pp. 291–304, Plenum Press, New York.Google Scholar
  10. Gross, M.M., 1973. Sensory Superactivity: A preliminary report on an hypothetical model for an hallucinogenic mechanism in alcohol withdrawal. In: (Ed.) M.M. Gross, Alcohol Intoxication and Withdrawal: Experimental Studies Advances in Experimental Medicine and Biology, Vol. 35, pp. 321–330, Plenum Press, New York.Google Scholar
  11. Gross, M.M., Lewis, E. and Hastey, J., 1974. Acute alcohol with-drawal syndrome. In: (Eds.) B. Kissin and H. Begleiter, The Biology of Alcoholism Vol. 3, pp. 191–264, Plenum Press, New York.Google Scholar
  12. Gross, M.M. and Best, S. (This volume) Behavioral concomitants of the relationship between baseline Slow Wave Sleep and carryover of tolerance and dependence in alcoholics.Google Scholar
  13. Gross, M.M. and Hastey, J.M. (This volume) The relation between baseline Slow Wave Sleep and the Slow Wave Sleep response to alcohol in alcoholics.Google Scholar
  14. Johnson, L.C., 1971. Sleep patterns in chronic alcoholics. In: (Eds.) N.K. Mello and J.H. Mendelson, Recent Advances in Studies of Alcoholism pp. 288–316, U.S. Government Printing Office, Washington, D.C.Google Scholar
  15. Kalant, H., LeBlanc, A.E. and Gibbins, R.J., 1971. Tolerance to, and dependence on some non-opiate psychotropic drugs. Pharmacological Reviews 23: 135–191.Google Scholar
  16. Kalant, H., 1973. Biological models of alcohol tolerance and physical dependence. In: (Ed.) M.M. Gross, Alcohol Intoxication and Withdrawal: Experimental Studies Advances in Experimental Medicine and Biology, Vol. 35, pp. 3–13, Plenum Press, New York.Google Scholar
  17. Lester, B.K., Rundell, O.H., Cowden, L.C. and Williams, H.L., 1973. Chronic alcoholism, alcohol and sleep. In: (Ed.) M.M. Gross, Alcohol Intoxication and Withdrawal: Experimental Studies, Advances in Experimental Medicine and Biology, Vol 35, PP. 261–279, Plenum Press, New York.Google Scholar
  18. Mendelson, J.H., Stein, S. and McGuire, M.T., 1966. Comparative psychophysiological studies of alcoholic and nonalcoholic subjects undergoing experimentally induced ethanol intoxication. Psychosom. Med. 28:1.Google Scholar
  19. Rechtschaffen, A. and Kales, A., 1968. A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects. U.S. Government Printing Office, Washington, D.C.Google Scholar
  20. Rosenblatt, S.M., Gross, M.M., Malenowski, B., Broman, M. and Lewis, E., 1972. Factor analysis of the daily clinical course rating scale of the acute alcoholic psychoses. Quart. J. Stud. Alp. 33: 1060–1064.Google Scholar
  21. Wagman, A. and Allen, R.P. (This volume) Effects of alcohol ingestion and abstinence on Slow Wave Sleep of alcoholics.Google Scholar
  22. Weiss, A.D., Victor, M., Mendelson, J.H. and La Dou, J., 1964. Electroencephalographic findings. In: (Ed.) J.H. Mendelson, Experimentally Induced Chronic Intoxication and Withdrawal in Alcoholics Quart. J. Stud. Alc. Suppl. 2, pp. 96–99.Google Scholar
  23. Zarcone, V., Barchas, J., Hoddes, E., Montplaisir, J., Sack, R. and Wilson, R. (This volume) Experimental ethanol ingestion: Sleep variables and metabolites of Dopamine and Serotonin in the cerebrospinal fluid.Google Scholar

Copyright information

© Springer Science+Business Media New York 1975

Authors and Affiliations

  • Milton M. Gross
    • 1
  • John M. Hastey
    • 1
  • Eastlyn Lewis
    • 1
  • Norma Young
    • 1
  1. 1.Division of Alcoholism & Drug Dependence, Dept. of PsychiatryDownstate Medical CenterBrooklynUSA

Personalised recommendations