Correlation of Brain Amine Changes with Ethanol-Induced Sleep-Time in Mice

  • C. K. Erickson
  • J. A. Matchett
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 59)


Earlier studies in our laboratories (Erickson and Graham, 1973; Graham and Erickson, 1974) have pointed out our interest in correlating central amine changes with certain aspects of ethanol intoxication. In the earlier studies we saw changes in acetylcholine (ACh) release from the cerebral cortex and reticular formation after various intravenous doses of ethanol in rabbits. Available literature concerning the effects of ethanol on catecholand indolealkylamines is voluminous, but incomplete and sometimes conflicting. For example, ethanol has been reported to deplete serotonin (5HT) and norepinephrine (NE) in the brain stem of rabbits (Gursey and Olson, 1960), and to raise brain 5HT of rats (Bonnycastle et al., 1962). Many workers, such as Häggendal and Lindqvist (1961), however, have seen no effect of ethanol on cerebral NE, DA or 5HT in rats or rabbits. Wallgren and Barry (1970) have concluded that, in general, ethanol appears to change brain levels of catecholamines and 5HT little, if at all. With regard to the effects of ethanol on the central amine ACh, Kalant et al. (1967) have seen decreased release of ACh in rat cortical slices in vitro while we have seen a short-lived increase in total brain ACh after ethanol in rats (Erickson and Graham, 1973).


Brain Level Central Neurotransmitter Darkened Symbol Total Amine Brain Amine 
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Copyright information

© Springer Science+Business Media New York 1975

Authors and Affiliations

  • C. K. Erickson
    • 1
  • J. A. Matchett
    • 1
  1. 1.Department of Pharmacology and Toxicology School of PharmacyUniversity of KansasLawrenceUSA

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