A Behavioral and Electrophysiological Analysis of Ethanol Dependence in the Rat

  • Don W. Walker
  • Bruce E. Hunter
  • Joseph Riley
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 59)


The identification of the neurobiological concomitants of ethanol dependence and withdrawal would not only provide a better understanding of the basic nature of such phenomena, but would also facilitate the development of techniques of detection, prevention, and treatment of alcoholic disease and its psychobiological consequences.


Ethanol Consumption Alcohol Withdrawal Ethanol Exposure Alcohol Withdrawal Syndrome Withdrawal Sign 
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  1. Branchey, M., Rauscher, G., and Kissin, B. Modifications in the response to alcohol following the establishment of physical dependence. Psychopharmacologia (Berl.), 22: 314–322, 1971.CrossRefGoogle Scholar
  2. Ellis, F. W., and Pick, J. R. Dose-and time-dependent relationships in ethanol-induced withdrawal reactions. Fed. Proc., 30: 568, 1971.Google Scholar
  3. Falk, J. L., Samson, H. H., and Winger, G. Behavioral maintenance of high concentrations of blood ethanol and physical dependence in the rat. Science, 177: 811–813, 1972.CrossRefGoogle Scholar
  4. Falk, J. L., Samson, H. H., and Tang, M. Chronic ingestion techniques for the production of physical dependence of ethanol. In M. M. Gross (Ed.) Alcohol Intoxication and Withdrawal: Experimental Studies I pp. 197–212. New York, Plenum Press, 1973.CrossRefGoogle Scholar
  5. Freund, G. Exchangeable injection port cartridge for gas chromatographic determination of volatile substances in aqueous fluids. Anal. Chem., 39: 545–546, 1967.Google Scholar
  6. Freund, G. Alcohol withdrawal syndrome in mice. Arch. Neurol., 21: 315–320, 1969.CrossRefGoogle Scholar
  7. Freund, G. Alcohol consumption and its circadian distribution in mice. J. Nutr., 100: 30–36, 1970.Google Scholar
  8. Freund, G. Alcohol, barbiturate, and bromide withdrawal syndrome in mice. Ann. N. Y. Acad. Sci., 215: 224–234, 1973.CrossRefGoogle Scholar
  9. Freund, G., and Walker, D.W. Impairment of avoidance learning by prolonged ethanol consumption in mice. J. Pharmacol. Exp. Ther., 179: 284–292, 1971.Google Scholar
  10. Goldstein, D. B. Relationship of alcohol dose to intensity of withdrawal signs in mice. J. Pharmacol. Exp. Ther., 180: 203–215, 1972a.Google Scholar
  11. Goldstein, D. B. An animal model for testing effects of drugs on alcohol withdrawal reactions. J. Pharmacol. Exp. Ther., 183: 14–22, 1972b.Google Scholar
  12. Hunt, W. A., and Majchrowicz, E. Turnover rates and steady-state levels of brain serotonin in alcohol-dependent rats. Brain Research, 72: 181–184, 1974.CrossRefGoogle Scholar
  13. Hunter, B. E., Boast, C. A., Walker, D. W., and Zornetzer, S. F. Alcohol withdrawal syndrome in rats: Neural and behavioral correlates. Pharmac. Biochem. Behay., 1: 719–725, 1973.CrossRefGoogle Scholar
  14. Hunter, B. E., Walker, D. W., and Riley, J. N. Dissociation between physical dependence and volitional ethanol consumption: Role of multiple withdrawal episodes. Pharmac. Biochem. Behay., 1974. (in press)Google Scholar
  15. Kalant, H., LeBlanc, A. E., and Gibbins, R. J. Tolerance to and dependence on, ethanol. In Y. Israel and J. Mardones (Eds.) Biological Basis of Alcoholism pp. 235–269. New York, Wiley-Interscience, 1971.Google Scholar
  16. Lieber, C. S., and DeCarli, L. M. Ethanol dependence and tolerance: A nutritionally controlled experiment model in the rat. Res. Commun. Chem. Pathol. Pharmacol., 6: 983–991, 1973.Google Scholar
  17. Littleton, J. M., Griffiths, P. J., and Ortiz, A. The induction of ethanol dependence and the ethanol withdrawal syndrome. J. Pharm. Pharmacol. 26: 81–91, 1974.CrossRefGoogle Scholar
  18. Mello, N. K. A review of methods to induce alcohol addiction in animals. Pharmac. Biochem. Behay., 1: 89–101, 1973.CrossRefGoogle Scholar
  19. Ogata, H., Ogata, F., Mendelson, J. H., and Mello, N. K. A comparison of techniques to induce alcohol dependence and tolerance in the mouse. J. Pharmac. Exp. Ther., 180: 216–230, 1972.Google Scholar
  20. Pohorecky, L. A. Effects of ethanol on central and peripheral noradrenergic neurons. J. Pharmacol. Exp. Ther., 189: 380–391, 1974.Google Scholar
  21. Pohorecky, L. A., Jaffe, L. S., and Berkeley, H. A. Effects of ethanol on serotonergic neurons in the rat brain. Res. Commun. Chem. Pathol. Pharmacol., 8: 1–11, 1974.Google Scholar
  22. Seevers, J. H., and Deneau, G. A. Physiological aspects of tolerance and physical dependence. In W. S. Root and F. G. Hoffmann (Eds.) Physiological Pharmacology pp. 565–640. New York, Academic Press, 1963.Google Scholar
  23. Walker, D. W., and Freund, G. Impairment of shuttlebox avoidance learning following prolonged alcohol consumption in rats. Physiol. Behay., 7: 773–778, 1971.CrossRefGoogle Scholar
  24. Walker, D. W., and Zornetzer, S. F. Alcohol withdrawal in mice: Electroencephalographic and behavioral correlates. Electroencephalogr. Clin. Neurophysiol., 36: 233–243, 1974.CrossRefGoogle Scholar
  25. Wallgren, H. Neurochemical aspects of tolerance to and dependence on ethanol. In M. M. Gross (Ed.) Alcohol Intoxication and Withdrawal: Experimental Studies pp. 15–32. New York, Plenum Press, 1973.Google Scholar
  26. Wallgren, H., and Barry, H., III. Actions of alcohol. New York: Elsevier, 1970.Google Scholar

Copyright information

© Springer Science+Business Media New York 1975

Authors and Affiliations

  • Don W. Walker
    • 1
  • Bruce E. Hunter
    • 1
  • Joseph Riley
    • 1
  1. 1.Veterans Administration Hospital and Department of NeuroscienceUniversity of FloridaGainesvilleUSA

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