Establishment of Ethanol as a Reinforcer for Rhesus Monkeys Via the Oral Route: Initial Results

  • Richard A. Meisch
  • Jack E. Henningfield
  • Travis Thompson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 59)


Ethanol functions as a reinforcer for rhesus monkeys when it is self-administered intravenously (Deneau, Yanagita and Seevers, 1969; Winger and Woods, 1973; Woods, Ikomi and Winger, 1971) or intragastricly (Yanagita and Takahashi, 1973). However, it has been reported that ethanol is not drunk by rhesus monkeys in either large quantities or at high concentrations except under special circumstances. For example, if rhesus monkeys are totally restricted to a liquid diet containing ethanol, physiological dependence develops (Pieper and Skeen, 1972). In three of four rhesus monkeys the chronic intraventricular infusion of ethanol resulted in abrupt and intermittent increases in ethanol intake (Myers, Veale and Yaksh, 1972), but such increases were not found in another study (Koz and Mendelson, 1967). Following a six-day interruption in the monkeys’ continuous access to ethanol, reintroduction of access to ethanol resulted in a pronounced but transient increase in intake (Sinclair, 1971).


Rhesus Monkey Aversive Taste Ethanol Intake Food Stimulus Liquid Reinforcement 
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Copyright information

© Springer Science+Business Media New York 1975

Authors and Affiliations

  • Richard A. Meisch
    • 1
  • Jack E. Henningfield
    • 1
  • Travis Thompson
    • 1
  1. 1.Psychiatry Research UnitUniversity of MinnesotaMinneapolisUSA

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