Alteration of Ethanol Preference in Rats; Effects of β-Carbolines

  • Irving Geller
  • Robert Purdy
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 59)


Our interest in the β-carbolines as influencing factors in alcohol preference stems from the early work of Mclsaac (1961) who reported the in vitro formation of 6-methoxytetrahydroharman as a condensation product of 5-methoxytryptamine and acetaldehyde. When rats were administered these agents in conjunction with their respective metabolic inhibitors, iproniazed and disulfiram, small amounts of 6-methoxytetrahydroharman were found in the urine. These findings were recently confirmed by Dajani and Sehab (1973). They reported the isolation of labelled ß-carbolines in 24 hour urine samples of rats administered labelled ethanol and 5-hydroxytryptophan or 5-methoxytryptophan.


Alcohol Intake Monoamine Oxidase Ethanol Intake Brain Serotonin York Acad 
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  1. Mclsaac, W. M. “Formation of 1-methyl-6-methoxy-1,2,3,4-tetrahydro-2-carboline Under Physiological Conditions.” Biochim. Biophys. Acta 52: 607, 1961.CrossRefGoogle Scholar
  2. Dajani, R. M. and Saheb, S. E. “A Further Insight into the Metabo- lism of Certain 3-Carbolines.” Annals New York Acad. Sci. 215: 120, 1973.Google Scholar
  3. Cohen, G. and Collins, M. “Alkaloids from Catecholamines in Adrenal Tissue: Possible Role in Alcoholism.” Sci. 167: 1749, 1970.CrossRefGoogle Scholar
  4. Davis, V. E. and Walsh, M. J. “Alcohol Amines and Alkaloids. A Possible Biochemical Basis for Alcohol Addiction.” Sci. 167: 1005, 1970.CrossRefGoogle Scholar
  5. Geller, I., Purdy, R., and Merritt, J. “Alterations in Ethanol Preference in the Rat: The Role of Brain Biogenic Amines.” Annals New York Acad. Sci. 215: 54, 1973.Google Scholar
  6. Myers, R. D. and Holman, R. B. “A Procedure for Eliminating Position Habits in Preference-Aversion Tests for Ethanol and Other Fluids.” Psychon. Sci. 6: 235, 1966.CrossRefGoogle Scholar
  7. Geller, I. “Ethanol Preference in the Rat as a Function of Photoperiod.” Sci. 173: 456, 1971.CrossRefGoogle Scholar
  8. Geller, I. “Effects of Para-Chlorophenylalanine and 5-Hydroxytryptophan on Alcohol Intake in the Rat.” Pharmacol. Biochem. and Behavior 1: 361–365, 1973.CrossRefGoogle Scholar
  9. Ho, B. T., Taylor, D. and Mclsaac, W. M. “Studies on the Mechanism of action of 6-methoxytetrahydro-6-Carboline in Elevating Brain Serotonin.” In Brain Chemistry and Mental Disease. Beng T. Ho and William M. Mclsaac, Editors. 1: 97–112, 1971.CrossRefGoogle Scholar
  10. Mclsaac, W. M. and Estevez, V. “Structure-action Relationships of S-carbolines as Monoamine Oxidase Inhibitors.” Biochem. Pharmacol. 15: 1625–1627, 1966.CrossRefGoogle Scholar
  11. Ho. B. T., Mclsaac, W. M. and Tansey, L. W. “Inhibitors of Monoamine Oxidase IV: 6 (or 8) Substituted Tetrahydro-8-carbolines and Their 9-Methyl Analogues.” J. Pharmac. Sci. 58: 998–1001, 1969.Google Scholar
  12. Ho, B. T., Mclsaac, W. M., Walker, K. R. and Estevez, V. “Inhibitors of Monoamine Oxidase:Influence of Methyl Substitution on the Inhibitory Activity of S-carbolines.” J. Pharmac. Sci. 57: 269–273, 1968.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1975

Authors and Affiliations

  • Irving Geller
    • 1
  • Robert Purdy
    • 1
  1. 1.Southwest Foundation for Research and EducationSan AntonioUSA

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