The Binding of Alcohol to Brain Membranes

  • Robert G. Grenell
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 59)


It has been our thesis that the primary action of alcohol in the central nervous system is on cell membranes. The conceptual and experimental background for such a contention has been reviewed to a large extent by Grenell (1957, 1959, 1971), Kalant (1971), Seeman (1972) and, in certain related respects by Mullins (1954).


Synaptic Membrane Brain Membrane Erythrocyte Ghost Microwave Region Discontinuous Sucrose Density Gradient 
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  1. Cooke, R. and Kuntz, I.D. 1974 Ann. Rev. Biophysics and Bioeng.Google Scholar
  2. Grenell, R. G. 1957 Paper in ‘Alcoholism’, ( H.Himwich, ed. ), AAAS Publ. No. 47.Google Scholar
  3. Grenell, R. G 1959 Quart. J. Stud. Alc 20: 421Google Scholar
  4. Grenell, R. G. 1971 Chapter 1, Vol. II of ‘The Biology of Alcohol’, ed. by Kissin and Begleiter, Plenum Press, N.Y.Google Scholar
  5. Kalant, H. 1971 Chapter in Vol. II of ‘The Biology of Alcohol’ ed, by Kissin and Begleiter, Plenum Press, N. YGoogle Scholar
  6. Mullins, L. J. 1954 Chem. Rev54: 289Google Scholar

Copyright information

© Springer Science+Business Media New York 1975

Authors and Affiliations

  • Robert G. Grenell
    • 1
  1. 1.Institute of Psychiatry & Human BehaviorUniversity of Maryland School of MedicineBaltimoreUSA

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