Factors Controlling the Rate of Alcohol Disposal by the Liver

  • Hans A. Krebs
  • Marion Stubbs
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 59)


The acute effects of ethanol on the nervous system depend on how rapidly ethanol is removed from the blood circulation after the intake. Thus it is of interest to study the factors responsible for the removal of ethanol in the liver, the main site of ethanol disposal. We therefore examined systematically the rate of alcohol removal by the liver, using isolated hepatocytes as experimental material. This is convenient material because many parallel experiments can be carried out on one homogeneous suspension. Tests in many laboratories so far have not revealed any major differences in the behaviour of the intact perfused liver and the isolated hepatocytes. When suitable conditions are chosen quantitative differences disappear, or are minimal (Krebs, Cornell, Lund and Hems, 1974).


Alcohol Dehydrogenase Ethanol Oxidation Acetate Formation Urea Synthesis Isolate Liver Cell 
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Copyright information

© Springer Science+Business Media New York 1975

Authors and Affiliations

  • Hans A. Krebs
    • 1
    • 2
  • Marion Stubbs
    • 1
    • 2
  1. 1.Metabolic Research LaboratoryNuffieldUK
  2. 2.Department of Clinical MedicineRadcliffe InfirmaryOxfordEngland

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