Abstract
It is axiomatic that the extraordinary diversity in form and function of cells, tissues, and organs within a higher organism results not from differences in their genomic composition, but from the finely tuned selective expression of portions of their common genetic repertoires. The fact that steroids act as gene-regulating molecules, and that they do so, for the most part, by acting as allosteric modifiers of their respective receptor (R) proteins, has focused much attention on the manner in which steroid—receptor (S—R) complexes act to regulate gene expression, particularly at the level of gene transcription.
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Keywords
- Androgen Receptor
- Luteinizing Hormone
- Glucocorticoid Receptor
- Steroid Receptor
- Androgen Receptor Protein
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
References
Abou-Issa, H., Foecking, M. K., and Minton, J. P., 1982, Regulation of estrogen—receptor binding by phosphorylation-dephosphorylation, Fed. Proc. 41: 1164–1169.
Agarwal, M. K., Philippe, M., and Coupry, F., 1978, Tissue dependent receptor binding of 9a-fluorohydrocortisone, Biochem. Biophys. Res. Commun. 83: 1–6.
Ahn, Y. S., Harrington, W. J., Simon, S. R., Mylvaganam, R., Pall, L. M., and So, A. G., 1983, Danazol for the treatment of idiopathic thrombocytopenic purpura, N. Engl. J. Med. 308: 1396–1399.
Aiman, J., and Griffin, J. E., 1982, The frequency of androgen receptor deficiency in infertile men, J. Clin. Endocrinol. Metab. 54: 725–732.
Aiman, J., Griffin, J. E., Gazak, J. M., Wilson, J. D., and MacDonald, P. C., 1979, Androgen insensitivity as a cause of infertility in otherwise normal men, N. Engl. J. Med. 300: 223–227.
Ali, M., and Vedeckis, W. V., 1986, Purification and characterization of glucocorticoid receptor-associated RNA, Program of the 68th Annual Meeting of the Endocrine Society, June, p. 297 (Abstract #1065).
Alvesalo, L., and Varrela, J., 1980, Permanent tooth sizes in 46,XY females, Am. J. Hum. Genet. 32: 736–742.
Amento, E. P., Bhalla, A. K., Kurnick, J. T., Kradin, R. L., Clemens, T. L., Holick, S. A., Holick, M. F., and Krane, S. M., 1984, Bdihydroxyvitamin D3 induces maturation of the human monocyte cell U937, and in association with a factor from human T lymphocytes, augments production of monokine mononuclear cell factor, J. Clin. Invest. 73: 731–739.
Amrhein, J. A., Meyer, W. J., III, Danish, R. K., and Migeon, C. J., 1977. Studies of androgen production and binding in 13 male pseudohermaphrodites and 13 males with micropenis, J. Clin. Endocrinol. Metab. 45: 732–738.
Anand, S. K., Froberg, L., Northway, J. D., Weinberger, M., and Wright, J. C., 1976, Pseudohypoaldosteronism due to sweat gland dysfunction, Pediatr. Res. 10: 677–682.
Anderson, J. N., 1984, The effect of steroid hormones on gene transcription, in: Biological Regulation and Development, Volume 3B ( R. F. Goldberger, and K. R. Yamamoto, eds.), pp. 169–212, Plenum Press, New York.
Anderson, E. E., and Tymoczko, J. L., 1985, Stabilization of glucocorticoid receptor association with RNA by a low molecular weight factor from rat liver cytosol, J. Steroid Biochem. 23: 299–306.
Antakly, T., 1986, Regulation of glucocorticoid receptor expression in rat intermediate pituitary lobe, Program of the 68th Annual Meeting of the Endocrine Society, June, p. 265 (Abstract #936).
Antakly, T., and Eisen, H. J., 1984, Immunocytochemical localization of glucocorticoid receptor in target cells, Endocrinology 115: 1984–1989.
Antakly, T., and Thompson, E. B., 1986, Localization of the glucocorticoid receptor in steroid-sensitive and steroid-resistant human leukemic cell lines. Int. Council Sci. Unions Short Reports 4: 258–259.
Arbus, G. S., Thomer, P., Celermajer, D., and Baumal, R., 1983, Sex differences in childhood lupus nephritis, Ann. Coll. Physicians Surgeons Can. 16: 379.
Armanini, D., Kuhnle, U., Strasser, T., Dorr, H., Butenandt, I., Weber, P. C., Stockigt, J. R., Pearce, P., and Funder, J. W. 1985, Aldosterone-receptor deficiency in pseudohypoaldosteronism, N. Engl. J. Med. 313: 1178–1181.
Arya, S. K., and Yang, J. T., 1975, Interaction of steroids with nucleic acids, Biochemistry 14: 963–969.
Attardi, B., and Ohno, S., 1974, Cytosol androgen receptor from kidney of normal and testicular feminized (Tfm) mice, Cell 2: 205–212.
Auricchio, F., Migliaccio, A., Castoria, G., Lastoria, S., and Scheavone, E., 1981, ATP-dependent enzyme activating hormone binding of estradiol receptor. Biochem. Biophvs. Res. Commun. 101: 1171–1178.
Bailly, A., LeFevre, B., Savouret, J.-F., and Milgrom, E., 1980, Activation and changes in sedimentation properties of steroid receptors, J. Biol. Chem. 255: 2729–2734.
Ballard, P. L., and Tomkins, G. M., 1969, Hormone induced modification of the cell surface, Nature 224: 344–345.
Banner, A. S.. Carrington, C. B., Emory, W. B., Kittle, F., Leonard. G., Ringus, J., Taylor, P., and Addington, W. W., 1981, Efficacy of oophorectomy in lymphangioleiomyomatosis and benign metastasizing leiomyoma, N. Engl. J. Med. 305: 204–209.
Bannister, P., Sheridan, P., and Losowsky, M. S., 1985, Use of a new radioactive ligand, 7a,17a-dimethyl [17a-methyl 3H] 19-nortestosterone for the estimation of androgen receptors in rat liver cytosol, J. Steroid Biochem. 23: 121–123.
Barnett, C. A., and Speck, L., 1986, A macromolecular factor that regulates glucocorticoid receptor functionality in a molybdate-like manner, Program of the 68th Annual Meeting of the Endocrine Society, June, p. 299 (Abstract #1073).
Barowski-Miller, P. A., and Gelehrter, T. D., 1984, Paradoxical effects of glucocorticoids on regulation of plasminogen activator activity: Mediation by glucocorticoid receptors, J. Steroid Biochem. 20: 533–537.
Barrack, E. R., 1983, The nuclear matrix of the prostate contains acceptor sites for androgen receptor, Endocrinology 113: 430–432.
Barrack, E. R., 1984, Nuclear acceptor sites in steroid action: The nuclear matrix, in: Proceedings of the 7th International Congress of Endocrinology ( F. Labrie, and L. Proulx, eds.), pp. 107–110, Excerpta Medica, Amsterdam.
Barrack, E. R., and Coffey, D. S., 1982, Biological properties of the nuclear matrix: Steroid hormone binding, Rec. Prog. Horm. Res. 38: 133–195.
Barthe, P. L., Bullock, L. P., Mowszowicz, I., Bardin, C. W., and Orth, D. N., 1974, Submaxillary gland epidermal growth factor: A sensitive index of biologic androgen activity, Endocrinology 95: 1019–1025.
Barton, J. K., Basile, L. A., and Paranawithana, S. R., 1982, The presence of zinc in the restriction enzyme Eco RI, J. Biol. Chem. 257: 7911–7914.
Baskevitch, P. P., Vignon, F., Bousquet, C., and Rochefort, H., 1983, Increased DNA binding of the estrogen receptor in an estrogen-resistant mammary cancer, Cancer Res. 43: 2290–2297.
Batchelor, J. R., Welsh, K. T., Tinoco, R. M., Dollery, C. T.. Hughes. G. R. V., Bernstein, R., Ryan, P., Naish, P. F., Aber, G. M., Bing, R. F., and Russell, G. I., 1980, Hydralazine-induced systemic lupus erythematosus: Influence of HLA-DR and sex on susceptibility, Lancet 1: 1107–1109.
Bauer, S. B., Bull, M. J., and Retik, A. B., 1979, Hypospadias: A familial study, J. Urol. 121: 474–477.
Belisle, S., Bellabarba, D., and Lehoux, J.-G., 1985, On the presence of nonfunctional uterine estrogen receptors in middle-aged and old C57BL/6J mice, Endocrinology 116: 148–153.
Benbow, C. P., and Stanley, J. C., 1980, Sex differences in mathematical ability: Fact or artifact?, Science 210: 1262–1264.
Berger, E. M., and Morganelli, M., 1984, Drosophila cells and ecdysterone: A model system for gene regulation, In Vitro 20: 959–974.
Berger, F. G., Szymanski, P., Read, E., and Watson, G., 1984, Androgen-regulated ornithine decarboxylase mRNAs of mouse kidney, J. Biol. Chem. 259: 7941–7946.
Berkovitz, G. D., and Brown, T. R., 1986, Dexamethasone represses glucocorticoid receptor binding in whole cell and nuclear matrix preparations of human skin fibroblasts, Program of the 68th Annual Meeting of the Endocrine Society. June, p. 301 (Abstract #1081).
Berliner, J. A., and Gerschenson, L. E., 1975, The effects of a glucocorticoid on the cell surface of RLC-GAI cells, J. Cell. Physiol. 86: 523–532.
Bishop, J. M., 1986, Oncogenes as hormone receptors, Nature 321: 112–113.
Blondeau, J.-P., Beaulieu, E.-E., and Robel, P., 1982, Androgen-dependent regulation of androgen nuclear receptor in the rat ventral prostate, Endocrinology 110: 1926–1932.
Bodwell, J. E., Holbrook, N. J., and Munck, A., 1984, Sulfhydryl-modifying agents reversibly inhibit binding of glucocorticoid-receptor complexes to DNA—cellulose, Biochemistry 23: 1392–1398.
Bolton, N. J., Lahtonen, R., Hammond, G. L., and Vihko, R., 1981, Distribution and concentrations of androgens in epithelial and stromal compartments of the human benign hypertrophie prostate, J. Endocrinol. 90: 125–131.
Bonne, C., Saurat, J.-H., Chivot, M., Lehuchet, D., and Raynaud, J.-P., 1977, Androgen receptor in human skin, Br. J. Dermatol. 97: 501–503.
Bosson, D., Mees, N., Ramet, J., Vamos, E., Vertongen, F., and Wolter, R., 1985, Generalized mineralocorticoid unresponsiveness: Familial recessive pseudohypoaldosteronism, Pediatr. Res. 19: 624.
Boyar, R. M., Moore, R. J., Rosner, W., Aiman, J., Chipman, J., Madden, J. D., Marks, J. F., and Griffin, J. E., 1978, Studies of gonadotropin—gonadal dynamics in patient with androgen insensitivity, J. Clin. Endocrinol. Metab. 47: 1116–1122.
Bransome, E. D., Jr., Hutson, M. S., and Hendry, L. B., 1986a, Structure—activity relationships of corticosteroid agonists and antagonists are predicted by the stereochemistry of DNA, Program of the 68th Annual Meeting of the Endocrine Society, June, p. 214 (Abstract #735).
Bransome, E. D., Jr., Lehner, A. F., Muldoon, T. G., Mahesh, V. B., Hutson, M. S., and Hendry, L. B., 19866, Structure-activity relationships of glucocorticoid agonists and antagonists are predicted by the stereochemistry of DNA, Clin. Res. 34: 213A.
Breedlove, S. M., and Arnold, A. P., 1981, Sexually dimorphic motor nucleus in the rat lumbar spinal cord: Response to adult hormone manipulation, absence in androgen-insensitive rats, Brain Res. 225: 297–307.
Breedlove, S. M., Jacobsen, C. D., Gorski, R. A., and Arnold, A. P., 1982, Masculinization of the female rat spinal cord following a single injection of testosterone propionate but not estradiol benzoate, Brain Res. 237: 173–181.
Breslow, J. L., and Epstein, J., 1980, Differential killing of normal and cystic fibrosis fibroblasts by dexamethasone, Science 207: 1007–1008.
Breslow, J. L., and McPherson, J., 1981, Sodium transport in cystic-fibrosis fibroblasts not different from normal, N. Engl. J. Med. 305: 98.
Breslow, J. L., Epstein, L., and Fontaine, J. H., 1978, Dexamethasone-resistant cystic fibrosis fibroblasts show cross-resistance to sex steroids, Cell 13: 663–669.
Breslow, J. L., McPherson, J., and Epstein, J., 1981, Distinguishing homozygous and heterozygous cystic fibrosis fibroblasts from normal cells by differences in sodium transport, N. Engl. J. Med. 304: 1–5.
Brinkmann, A. O., Lindh, L. M., Breedvelt, D. I., Mulder, E., and van der Molen, H. J., 1983, Cyproterone acetate prevents translocation of the androgen receptor in the rat prostate, Mol. Cell. Endocrinol. 32: 117–129.
Brinkmann, A. O., Kuiper, G. G. J. M., de Boer, W., Mulder, E., and van der Molen, H. J., 1985, Photoaffinity labeling of androgen receptors with 173-hydroxy-17a[3H]methyl4,9,11-estratrien-3-one, Biochem. Biophys. Res. Commun. 126: 163–169.
Brown, A. M. C., Jeltsch, J.-M., Roberts, M., and Chambon, P., 1984, Activation of p52 gene transcription is a primary response to estrogen in the human breast cancer cell line MCF-7, Proc. Natl. Acad. Sci. USA 81: 6344–6348.
Brown, T. R., and Migeon, C. J., 1981, Cultured human skin fibroblasts: A model for the study of androgen action, Mol. Cell. Biochem. 36: 3–22.
Brown, T. R., Greene, F. E., Bullock, L. P., and Bardin, C. W., 1978, Effect of Tfm locus on the hepatic ethylmorphine N-demethylase system in mice, Endocrinology 103: 1374–1382.
Brown, T. R., Maes, M., Rothwell, S. W., and Migeon, C. J., 1982, Human complete androgen insensitivity with normal dihydrotestosterone receptor binding capacity: Evidence for a qualitative abnormality of the receptor, J. Clin. Endocrinol. Metab. 55: 6169.
Brown, T. R., Rothwell, S. W., and Migeon, C. J., 1983, Human androgen insensitivity does not alter oligonucleotide recognition by the androgen-receptor—DHT complex, Mol. Cell. Endocrinol. 32: 215–231.
Bruning, P.F., Meyer, W. J., III, and Migeon, C. J., 1979, Glucocorticoid receptor in cultured human skin fibroblasts, J. Steroid Biochem. 10: 587–593.
Bullock, L. P., 1982, Models of androgen insensitivity in the study of androgen action, in: Animal Models of Inherited Metabolic Disease ( R. J. Desnick, D. F. Patterson, and D. G. Scarpelli, eds.), pp. 369–379, Alan R. Liss, New York.
Bullock, W. W., Anderson, D., and Golding, B., 1980, Sex steroid influences on delayed type hypersensitivity in Lewis rats, Fed. Proc. 39: 1136 (Abstract 4574).
Burch, J. B. E., and Weintraub, H., 1983, Temporal order of chromatin structural changes associated with activation of the major chicken vitellogenin gene, Cell 33: 65–76.
Butley, M. S., Erickson, R. P., and Pratt, W. B., 1978, Hepatic glucocorticoid receptors and the H-2 locus, Nature 275: 136–138.
Buttyan, R., Olsson, C. A., Sheard, B., and Kallos, J., 1983, Steroid receptor—nuclear matrix interactions, J. Biol. Chem. 258: 14366–14370.
Callard, G. V., and Mak, P., 1985, Exclusive nuclear location of estrogen receptors in Squalus testis, Proc. Natl. Acad. Sci. USA 82: 1336–1340.
Cameo, M. S., Blaquier, J. A., and Burgos, M. H., 1971, The androgen dependency of the process of sperm maturation in the guinea pig, Acta Physiol. Lat. Am. XXI: 254–255.
Carlstedt-Duke, J., Okret, S., Wrange, O., and Gustafsson, J.-A., 1982, Immunochemical analysis of the glucocorticoid receptor: Identification of a third domain separate from the steroid-binding and DNA-binding domains, Proc. Natl. Acad. Sci. USA 79: 42604264.
Carriero, R., Gaubert, C.-M., Shyamala, G., 1987, Relationships between mammary estrogen receptors and estrogenic sensitivity. Effects of elevated temperature and ATP on cytoplasmic receptor and its binding to DNA, J. Endocrinol. (submitted).
Carter, C. O., 1973, Multifactorial genetic disease, in: Medical Genetics ( V. A. McKusick and R. Cailborne, eds.), p. 199, H. P. Publishing, New York.
Carter-Su, C., and Pratt, W. B., 1984, Receptor phosphorylation, in: The Receptors, Vol. 1 ( P. M. Conn, ed.), pp. 542–585, Academic Press, New York.
Catelli, M. G., Ziemiecki, A., Joab, I., Moncharmont, B., and Baulieu, E. E., 1986, Association of 90-kd heat shock protein with steroid hormone receptor and tyrosine kinase oncogene products, Program of the 68th Annual Meeting of the Endocrine Society, June, p. 281 (Abstract #1002).
Chaganti, P. S. K., and German, J., 1979, Human male infertility, probably genetically determined, due to defective meiosis and spermatogenesis arrest, Am. J. Hum. Genet. 31: 634–641.
Chaganti, P. S. K., Jhanwar, S. C., Ehrenbard, L. T., Kourides, I. A., and Williams, J. J., 1980, Genetically determined asynapsis, spermatogenic degeneration, and infertility in men, Am. J. Hum. Genet. 32: 833–848.
Chandler, V. L., Maler, B. A., and Yamamoto, K. R., 1983, DNA sequences bound specifically by glucocorticoid receptor in vitro render a heterologous promotor hormone responsive in vivo, Cell 33: 489–499.
Chandley, A. C., 1979, The chromosomal basis of human infertility, Br. Med. Bull. 35: 181–186.
Chang, C., and Liao, S., 1986, Interaction with steroid receptors and biological activity of nonsteroidal cyclic hydrocarbons, Program of the 68th Annual Meeting of the Endocrine Society, June, p. 308 (Abstract #709).
Cheek, D. B., and Perry, J. W., 1958, A salt wasting syndrome in infancy, Arch. Dis. Child. 33: 252–256.
Chin, R.-C., and Kidson, C., 1971, Selective associations of hormonal steroids with aminoacyl transfer RNAs and control of protein synthesis, Proc. Natl. Acad. Sci. USA 68: 2448–2452.
Chou, J. Y., 1983, Temperature-sensitive adult liver cell line dependent on glucocorticoid for differentiation, Mol. Cell. Biol. 3: 1013–1020.
Chowdhury, A. K., and Steinberger, E., 1975, Effect of 5a-reduced androgens on sex accessory organs, initiation and maintenance of spermatogenesis in the rat, Biol. Reprod. 12: 609–617.
Christensen, L. W., and Gorski, R. A., 1978, Independent masculinization of neuroendocrine systems by intracerebral implants of testosterone or estradiol in the neonatal female rat, Brain Res. 146: 325–340.
Chrousos, G. P., Renquist, D., Brandon, D., Eil, C., Pugeat, M., Vigersky, R., Cutler, G., Jr., Loriaux, D. L., and Lipsett, M. B., 1982a, Glucocorticoid hormone resistance during primate evolution: Receptor-mediated mechanisms, Proc. Natl. Acad. Sci. USA 79: 2036–2040.
Chrousos, G. P., Renquist, D., Brandon, D., Barnard, D., Fowler, D., Loriaux, D. L., and Lipsett, M. B., 19826, The squirrel monkey: Receptor-mediated resistance to progesterone?, J. Clin. Endocrinol. Metab. 55: 364–368.
Chrousos, G. P., Vingerhoeds, A., Brandon, D., Eil, C., Pugeat, M., DeVroede, M., Loriaux, D. L., and Lipsett, M. B., 1982c, Primary cortisol resistance in man: A glucocorticoid receptor-mediated disease, J. Clin. Invest. 69: 1261–1269.
Chrousos, G. P., Vingerhoeds, A. C. M., Loriaux, D. L., and Lipsett, M. B., 1983, Primary cortisol resistance: A family study, J. Clin. Endocrinol. Metab. 56: 1243–1245.
Chrousos, G. P., Loriaux, D. L., Brandon, D., Shull, J., Renquist, D., Hogan, W., Tomita, M., and Lipsett, M. B., 1984a, Adaptation of the mineralocorticoid target tissues to the high circulating cortisol and progesterone plasma levels in the squirrel monkey, Endocrinology 115: 25–32.
Chrousos, G. P., Tornita, M., Brandon, D. D., Loriaux, D. L., and Lipsett, M. B., 19846, Glucocorticoid insensitivity in man and nonhuman primates, in: Endocrinology (F. La-bries, and L. Proulx, eds.), pp. 853–856, Elsevier, Amsterdam.
Chuknyiska, R. S., Haji, M., Foote, R. H., and Roth, G. S., 1985, Age-associated changes in nuclear binding of rat uterine estradiol receptor complexes, Endocrinology 116: 547–551.
Cidlowski, J. A., and Cidlowski, N. B., 1981, Regulation of glucocorticoid receptors by glucocorticoids in cultured HeLa S3 cells, Endocrinology 109: 1975–1982.
Claire, M., Oblin, M.-E., Steimber, J.-L., Nakane, H., Misumi, J., Michaud, A., and Corvol, P., 1981, Effect of adrenalectomy and aldosterone on the modulation of mineralocorticoid receptors in rat kidney, J. Biol. Chem. 256: 142–147.
Clemens, T. L., Adams, J. S., Horiuchi, N., Gilchrest, B. A., Cho, H., Tsuchiya, Y., Matsuo, N., Suda, T., and Holick, M. F., 1983, Interaction of 1,25-dihydroxyvitaminD3 with keratinocytes and fibroblasts from skin of normal subjects and a subject with vitamin-D dependent rickets, type II: A model for study of the mode of action of 1,25dihydroxyvitamin D3, J. Clin. Endocrinol. Metab. 56: 824–830.
Cohen, J. H. M., Danel, L., Cordier, G., Saez, S., and Revillard, J.-P., 1983, Sex steroid receptor in peripheral T cells: Absence of androgen receptors and restriction of estrogen receptors to OKT8-positive cells, J. lmmunol. 131: 2767–2771.
Cohen, P. N., Givens, J. R., Wiser, W. L., Wilroy, R. S., Summitt, R. L., Coleman, S. A., and Andersen, R. N., 1975, Polycystic ovarian disease, maturation arrest and spermiogenesis, and Klinefelter’s syndrome in siblings of a family with familial hirsutism, Fertil. Steril. 12: 609–617.
Cohn, D. A., 1979, High sensitivity to androgen as a contributing factor in sex differences in the immune response. Arthritis Rheum. 22: 1218–1233.
Colston, K., Hirt, M., and Feldman, D., 1980, Organ distribution of the cytoplasmic 1,25dihydroxycholecalciferol receptor in various mouse tissues, Endocrinology 107: 1916–1922.
Colston, K., Colston, M. J., and Feldman, D., 1981, 1,25-Dihydroxyvitamin D3 and malignant melanoma: The presence of receptors and inhibition of cell growth in culture, Endocrinology 108: 1083–1086.
Colvard, D. S., and Wilson, E. M., 1984a, Androgen receptor binding to nuclear matrix in vitro and its inhibition by 8S androgen receptor promoting factor, Biochemistry 23: 3479–3486.
Colvard, D. S., and Wilson, E. M., 19846. Zinc potentiation of androgen receptor binding to nuclei in vitro, Biochemistry 23: 3471–3478.
Compton, M. M., and Cidlowski, J. A., 1986, Identification of a glucocorticoid-regulated deoxyribonuclease in lymphocytes: A new candidate for the lysis gene, Program of the 68th Annual Meeting of the Endocrine Society, June, p. 265 (Abstract #938).
Corrin, B., Liebow, A. A., and Friedman, P. J., 1975, Pulmonary lymphangiomyomatosis, A review, Am. J. Pathol. 79: 348–382.
Costa, E. M., Hirst, M. A., and Feldman, D., 1985, Regulation of 1,25-dihydroxyvitamin D3 receptors by Vitamin D analogs in cultured mammalian cells, Endocrinology 117: 2203–2210.
Coulam, C. B., Razel, A. J., Kelalis, P. P., Svensson, J., and Spelsberg, T. C., 1983, Androgen receptor in human foreskin. II. Characterization of the receptor from hypospadiac tissue, Am. J. Obstet. Gynecol. 147: 513–520.
Cox, R. F., Haines, M. E., and Emtage, J. S., 1974, Quantitation of ovalbumin mRNA in hen and chick oviduct by hybridization to complementary DNA, Eur. J. Biochem. 49: 225–236.
Croce, C. M., Litwack, G., and Koprowski, H., 1973, Human regulatory gene for inducible tyrosine aminotransferase in rat—human hybrids, Proc. Natl. Acad. Sci. USA 70: 1268–1272.
Cunha, G. R., Shannon, J. M., Taguchi, O., Fujii, H., and Chung, L. W. K., 1982a, Mesenchymal—epithelial interactions in hormone-induced development, J. Anim. Sci. 55 (Suppl. II): 14–31.
Cunha, G. R., Shannon, J. M., Vanderslice, K. D., Sekkingstad, M., and Robboy, S. J., 1982b, Autoradiographic analysis of nuclear estrogen binding sites during postnatal development of the genital tract of female mice, J. Steroid Biochem. 17: 281–286.
Cunha, G. R., Chung, L. W. K., Shannon, J. M., Taguchi, O., and Fujii, H., 1983, Hormone-induced morphogenesis and growth: Role of mesenchymal—epithelial interactions, Rec. Prog. Horm. Res. 39: 559–598.
Cunningham, G. R., Lobl, T. J., Cockrell, C., Shao, T.-C., and Trudall. D. J., 1983, Characterization of steroid binding specificity of the androgen receptor in human foreskin fibroblasts, Steroids 41: 617–626.
Dahlberg, E., Snochowski, M., and Gustafsson, J.-A., 1981, Regulation of the androgen and glucocorticoid receptors in rat and mouse skeletal muscle cytosol, Endocrinology 108: 1431–1440.
Dahmer, M. K., Housley, P. R., and Pratt, W. B., 1984, Effects of molybdate and endogenous inhibitors on steroid-receptor inactivation, transformation and translocation, Annu. Rev. Physiol. 46: 67–81.
Danel, L., Menouni, M., Sebban, C., Magaud, J. P., and Saez, S., 1984, Characterization of a specific androgen receptor in non-Hodgkin’s lymphoma cells, J. Steroid Biochem. 21: 421–426.
Danielson, M., and Stallcup, M. R., 1984, Down-regulation of glucocorticoid receptors in mouse lymphoma cell variants, Mol. Cell. Biol. 4: 449–453.
Daughaday, W. H., 1985, The anterior pituitary, in: Textbook of Endocrinology (J. D. Wilson, and D. W. Forster, eds.), 7th ed., Saunders, Philadelphia.
Dean, D. C., Knoll, B. J., Riser, M. E., and O’Malley, B. W., 1983, A 5’-flanking sequence essential for progesterone regulation of ovalbumin fusion gene, Nature 305: 551–554.
Dean, D. C., Gope, R., Knoll, B. J., Riser, M. E., and O’Malley, B. W., 1984, A similar 5’ flanking region is required for estrogen and progesterone induction of ovalbumin gene expression, J. Biol. Chem. 259: 9967–9970.
De Boer, W., Ab, G., and Gruber, M., 1985, Estrogen receptor in chicken oviduct: Receptor dissociation kinetics and transformation, J. Steroid Biochem. 23: 9–18.
Debuire, B., Henry, C., Benaissa, M., Biserte, G., Claverie, J. M., Saule, S., Martin, P., and Stehelin, D., 1984, Sequencing the erbA gene of avian erythroblastosis virus reveals a new type of oncogene, Science 224: 1456–1459.
DeFranco, D., Wrange, O., Merryweather, J., and Yamamoto, K. R., 1984, Biological activity of a glucocorticoid regulated enhancer: DNA sequence requirements and interactions with other transcriptional enhancers, in: Genome Rearrangements ( M. Simon, and I. Herskowitz, eds.), pp. 305–321, Alan R. Liss, New York.
De Kretser, D. M., 1979, Endocrinology of male infertility, Br. Med. Bull. 35: 187–192.
Densmore, C. L., Luttge, W. G., and Chou, Y.-C., 1986, Glucocorticoid receptor activation leads to changes in surface hydrophobicity as determined by hydrophobic interaction chromatography, Program of the 68th Annual Meeting of the Endocrine Society, June, p. 264 (Abstract #935).
Diamond, D. J., and Goodman, H. M., 1985, Regulation of growth hormone messenger RNA synthesis by dexamethasone and triiodothyronine transcriptional rate and mRNA stability changes in pituitary tumor cells, J. Mol. Biol. 181: 41–62.
DiBattista, J. A., Mehdi, A. Z., and Sandor, T., 1983, Intestinal triamcinolone acetonide receptors of the eel (Anguilla rostrata), Gen. Comp. Endocrinol. 51: 228–238.
Distelhorst, C. W., and Benutto, B. M., 1985, Activation of the rat liver cytosol glucocorticoid receptor by Sephacryl S-300 filtration in the presence and absence of molybdate. Physical properties of the receptor and evidence for an activation inhibitor, J. Biol. Chem. 260: 2153–2159.
d’Istria, M., Citarella, F., Iela, L., and Delrio, G., 1979, Characterization of a cytoplasmic androgen receptor in the male secondary sexual character of green frog (Rana Esculenta), J. Steroid Biochem. 10: 53–59.
Dougherty, J. J., Puri, R. K., and Toft, D. P., 1982, Phosphorylation in vivo of chicken oviduct progesterone receptor, J. Biol. Chem. 257: 14226–14230.
Drews, U., and Alonso-Lozano, V., 1974, X-inactivation pattern in the epididymis of sex-reversed mice heterozygous for testicular feminization, J. Embryo!. Exp. Morphol. 32: 217–225.
Drews, U., and Drews, U., 1975, Metabolic cooperation between Tfm and wild-type cells in mosaic mice after induction of DNA synthesis, Cell 6: 475–479.
Drouin, J., Jeannote, L., Plante, R. K., and Wrange, O., 1986, The pro-opiomelanocortin gene: DNA sequences required for tissue-specific expression and glucocorticoid inhibition of transcription, Program of the 68th Annual Meeting of the Endocrine Society, June, p. 31 (Abstract #14).
Duax, W. L., Griffin, J. F., Rohrer, D. C., Swenson, D. C., and Weeks, C. M., 1981, Molecular details of receptor binding and hormonal action of steroids derived from x-ray crystallographic investigations, J. Steroid Biochem. 15: 41–47.
Duax, W. L., Griffin, J. F., Rohrer, D. C., Weeks, C. M., and Ebright, R. H., 1984, Steroid hormone action interpreted from X-ray crystallographic studies, in: Biochemical Actions of Hormones, Vol. XI, pp. 187–205, Academic Press, New York.
Duax, W. L., Griffin, J. F., and Ebright, R., 1985, Structural basis for chemotherapeutic action of antiestrogens, in: Molecular Basis of Cancer, Part B: Macromolecular Recognition, Chemotherapy, and Immunology, pp. 263–273, Alan R. Liss, New York.
Dunn, J. F., and Wilson, J. D., 1976, Developmental study of androgen responsiveness in the submandibular gland of the mouse, Endocrinology 96: 1571–1578.
Duong, M. H., and Raymond, G. P., 1983, Unilateral dermatomal superficial telangiectasia, Can. Med. Assoc. J. 129: 1117–1118.
Eckert, R. L., Mullick, A., Rorke, E. A., and Katzenellenbogen, B. S., 1984, Estrogen receptor synthesis and turnover in MCF-7 breast cancer cells measured by a density-shift technique, Endocrinology 114: 629–637.
Ehrhardt, A. A., and Meyer-Bahlburg, H. F., 1981, Effects of prenatal sex hormones on gender-related behavior, Science 211: 1312–1318.
Eil, C., Merriam, G. R., Bowen, J., Ebert, J., Tabor, E., White, B., Douglas, E. C., and Loriaux, D. L., 1980, Testicular feminization in the chimpanzee, Clin. Res. 28: 624A (Abstract).
Eil, C., Lippman, M. E., De Moss, E. V., and Loriaux, D. L., 1983, Androgen receptor characteristics in skin fibroblasts from men with pubertal macromastia. Clin. Endocrinol. 19: 223–230.
Eil, C., Crawford, J. D., Donahoe, P. K., Johnsonbaugh, R. E., and Loriaux, D. L., 1984, Fibroblast androgen receptors in patients with genitourinary anomalies, J. Androl. 5: 313–320.
Eisen, H. J., 1982, Immunochemical approaches to the study of glucocorticoid receptor, in: Biochemical Actions of Hormones, Vol. 9 ( G. Litwack, ed.), pp. 255–270, Academic Press, New York.
Eisen, H. J., Schleenbaker, R. E., and Simons, S. S., Jr., 1981, Affinity labeling of the rat liver glucocorticoid receptor with dexamethasone-21-mesylate, J. Biol. Chem. 256: 12920–12925.
Eisen, L. P., Reichman, M. E., Thompson, E. B., Gametchu, B., Harrison, R. W., and Eisen, H. J., 1985, Monoclonal antibody to the rat glucocorticoid receptor: Relationship between the immunoreactive and DNA-binding domain. J. Biol. Chem. 260: 11805–11810.
Eisman, J. A., Martin, T. J., Maclntyre, I., and Moseley, J. M., 1979, 1,25-Dihydroxyvitamin D receptor in breast cancer cells, Lancet 11: 1335–1336.
Elawady, M. K., Allman, D. R., Griffin, J. E., and Wilson, J. D., 1983, Expression of a mutant androgen receptor in cloned fibroblasts derived from a heterozygous carrier for the syndrome of testicular feminization, Am. J. Hum. Genet. 35: 376–384.
Epstein, B., Breslow, J. L., and Davidson, R. L., 1977, Increased dexamethasone resistance of cystic fibrosis fibroblasts, Proc. Natl. Acad. Sci. USA 74: 5642–5646.
Epstein, B., Breslow, J. L., Fitzsimmonds, M. J., and Vayo, M. M., 1978, Pleiotropic drug resistance in cystic fibrosis fibroblasts: Increased resistance to cyclic AMP, Sotnat. Cell Genet. 4: 451–464.
Erickson, R. P., Heide!, L., Kapur, J. J., Karolyi, J. M., Odenheimer, D. J., Pairitz, G. L., Schultz, J. S., and Sing, C. F., 1985, HLA antigens, phytohemagglutinin stimulation, and corticosteroid response, Am. J. Hum. Genet. 37: 761–770.
Evain, D., Savage, M. O., and Binet, E., 1977, A specific and rapid determination of human skin dihydrotestosterone cytosol receptor, J. Clin. Endocrinol. Metab. 45: 363–366.
Evans, B. A. J., Jones, T. R., and Hughes, I. A., 1984, Studies of the androgen receptor in dispersed fibroblasts. Investigation of patients with androgen insensitivity, Clin. Endocrinol. 20: 93–105.
Federman, D. D. 1967 (ed), Abnormal Sexual Development: A Genetic and Endocrine Approach to Differential Diagnosis, W.B. Saunders, 1967.
Feldman, D., Funder, J., and Loose, D., 1978, Is the glucocorticoid receptor identical in various target organs?, J. Steroid Biochem. 9: 141–145.
Feldman, M., Kallos, J., and Hollander, V. P., 1981, RNA inhibits estrogen receptor binding to DNA, J. Biol. Chem. 256: 1145–1148.
Feldman, D., Do, Y., Burshell, A., Stathis, P., and Loose, D. S., 1982a, An estrogen-binding protein and endogenous ligand in Saccharomyces cerevisiae: Possible hormone receptor system, Science 218: 297–298.
Feldman, D., Chen, T., Cone, C., Hirst, M., Shani, S., Benderli, A., and Hochberg, Z., 1982b, Vitamin D resistant rickets with alopecia: Cultured skin fibroblasts exhibit defective cytoplasmic receptors and unresponsiveness to 1,25(OH)2D3, J. Clin. Endocrinol. Metab. 55: 1020–1022.
Fichman, K. R., Nyberg, L. M., Bujnovszky, B., Brown, T. R., and Walsh, P. C., 1981, The ontogeny of the androgen receptor in human foreskin, J. Clin. Endocrinol. Metab. 52: 919–923.
Finn, R., and Harmer, D., 1979, Aetiological implications of sex ratio in glomerulonephritis, Lancet 1: 1194.
Firestone, G. L., Payvar, F., and Yamamoto, Y., 1982, Glucocorticoid regulation of protein processing and compartmentalization, Nature 300: 721–225.
Fiskin, A. M., and Melnykovych, G., 1971, Prednisolone induced surface alterations in HeLa cells, Exptl. Cell Res. 66: 483–486.
Flessa, H., and Glueck, H., 1977, Hereditary hemorrhagic telangiectasia. Management of epistaxis in nine patients using systemic hormone therapy, Arch. Otolaryngol. 103: 148–151.
Forrest, G. L., 1981, Colchicine-binding activity and tyrosyl tubulin ligase activity in normal and cystic fibrosis fibroblasts, Biochem. Biophys. Res. Commun. 98: 324–329.
Fox, T. O., and Wieland, S. J., 1981, Isoelectric focusing of androgen receptors from wildtype and Tfm mouse kidneys, Endocrinology 109: 790–797.
Fox, T. O., Blank, D., and Politch, J. A., 1983, Residual androgen binding in testicular feminization (Tfm), J. Steroid Biochem. 19: 577–581.
Francke, J., and Gehring, U., 1980, Chromosome assignment of a murine glucocorticoid receptor gene (GR 1–1) using intraspecies somatic cell hybrids, Cell 22: 657–664.
Fraser, F. C., 1980, Evolution of a palatable multifactorial threshold model, Am. J. Hum. Genet. 32: 796–813.
Fraser, F. C., and Fainstat, T. D., 1951, Production of congenital defects in the offspring of pregnant mice treated with cortisone, Pediatrics 8: 527–533.
Fraser, F. C., and Warburton, D., 1964, No association of emotional stress of vitamin supplement during pregnancy to cleft lip or palate in man, Plastic Reconst. Surg. 33: 395399.
Fraser, D., Kooh, S. W., Kind, H. P., Holick, M. F., Tanaka, Y., and DeLuca, H. F., 1973, Pathogenesis of hereditary vitamin-D-dependent rickets: An inborn error of vitamin D metabolism involving defective conversion of 25-hydroxyvitamin D to la,25dihydroxyvitamin D, N. Engl. J. Med. 289: 817–822.
Froble, V. L., Fioretti, W. C., Ledford, B. E., and Boggett, B., 1979, Chick comb fibroblasts: A new strain of cultured cells sensitive to androgens, Mol. Cell. Endocrinol. 13: 35–45.
Fujii, H., Nawa, Y., Tsuchiya, H., Matsuno, K., Fukumoto, T., Fukuda, S., and Kotani, M., 1975, Effect of a single administration of testosterone on the immune response and lymphoid tissues in mice, Cell. Immunol. 20: 315–326.
Gad, Y. Z., Berkovitz, G. D., Migeon, C. J.,and Brown, T. R., 1986, Mechanism of androgen—receptor dependent induction of androgen binding in genital skin fibroblasts, Program of the 68th Annual Meeting of the Endocrine Society. June, p. 210 (Abstract #716).
Gadson, P. F., Russell, J. D., and Russell, S. B., 1984, Glucocorticoid receptors in human fibroblasts derived from normal dermis and keloid tissue, J. Biol. Chem. 259: 11236–11241.
Gal, A., and Venetianer, A., 1984, Genetic analysis of dexamethasone resistance in L cells by somatic cell hybridization, J. Steroid Biochem. 20: 307–310.
Garroway, N. W., Orth, D. N., and Harrison, R. W., 1976, Binding of cytosol receptorglucocorticoid complexes by isolated nuclei of glucocorticoid-responsive and nonresponsive cultured cells, Endocrinology 98: 1092–1100.
Gasson, J. C., and Bourgeois, S., 1983, A new determinant of glucocorticoid sensitivity in lymphoid cell lines, J. Cell Biol. 96: 409–415.
Gasson, J. C., Ryden, T., and Bourgeois, S., 1983, Role of de novo methylation in the glucocorticoid resistance of a T-lymphoid cell line, Nature 302: 621–623.
Gaubert, C. M., Tremblay, P. R., and Dubé, J. Y., 1980, Effect of sodium molybdate on cytosolic androgen receptors in rat prostate, J. Steroid Biochem. 13: 931–937.
Gaubert, C.-M., Carriero, R., and Shyamala, G., 1986, Relationships between mammary estrogen receptor and estrogenic sensitivity. Molecular properties of cytoplasmic receptor and its binding to deoxyribonucleic acid, Endocrinology 118: 1504–1512.
Gehring, U., 1983, Glucocorticoid receptors of wild-type and variant mouse lymphoma cells, J. Steroid Biochem. 19: 475–482.
Gehring, U., and Hotz, A., 1983, Photoaffinity labeling and partial proteolysis of wild-type and variant glucocorticoid receptors, Biochemistry 22: 4013–4018.
Gelehrter, T. D., 1968, Glucocorticoid regulation of plasminogen activation. Induction of a specific PA-inhibitor, Program of the 68th Annual Meeting of the Endocrine Society, June, P. 14 (Abstract).
George, F. W., and Wilson, J. D., 1982, Developmental pattern of increased aromatase activity in the Seabright-bantam chicken, Endocrinology 110: 1203–1207.
Giambiagi, N., Pasqualini, J. R., Greene, G., and Jensen, E. V., 1984, Recognition of two forms of the estrogen receptor in the guinea pig uterus at different stages of development by a monoclonal antibody to the human estrogen receptor. Dynamics of the translocation of these two forms to the nucleus, J. Steroid Biochem. 20: 397–400.
Giannopoulos, G., and Somers, S. K., 1982, Androgen receptors in fetal rabbit lung and effect of fetal sex on the levels of circulating hormones and pulmonary hormone receptors, J. Steroid Biochem. 17: 461–465.
Goidl, J. O., Cake, M. H., Dolan, K. P., Parchman, L. G., and Litwack. G., 1977, Activation of the rat liver glucocorticoid—receptor complex, Biochemistry 16: 2125–2130.
Gokal, P. K., Cavanaugh, A. H., Mahajan, P. B., and Thompson, E. A., 1986, The hormone-regulated rDNA transcription factor (TFIC) determines the extent of reinitiation of transcription in vitro, Int. Council Sci. Unions Short Reports 4: 284–285.
Gold, P. W., Loriaux, D. L., Roy, A., Kling. M. A., Calabrese, J. R., Kellner, C. H., Nieman, L. K., Post, R. M., Pickar, D., Gallucci, W., Avgerninos, P., Paul, S., Oldfield, E. H., Cutler, G. B., Jr., and Chrousos, G. P., 1986, Responses to corticotropin-releasing hormone in the hypercortisolism of depression and Cushing’s disease, N. Engl. J. Med. 314: 1329–1335.
Goldman, A. S., and Klingele, D. A., 1974, Feminine patterns of androgen metabolism and presence of z15,3ß-hydroxysteroid oxidoreductase in target organs of genetic rat male pseudohermaphrodites, Proc. Soc. Exp. Biol. Med. 146: 539–545.
Goidman, A. S., Gustafsson, J.-A., and Gustafsson, S. A., 1973, Female pattern of metabolism of (4–14C) corticosterone in male pseudohermaphroditic rats, Proc. Soc. Exp. Biol. Med. 142: 691–696.
Gomi, M., Iida, S., Tsugawa, M., Itoh, Y., Moriwaki, K., Yamashita, S., and Tarui, S., 1986, Decreased glucocorticoid receptors in cultured skin fibroblasts from a patient with primary cortisol resistance, N. Engl. J. Med. 314: 1194.
Gordon, D., and Williams, D. L., 1986, Estrogen regulates the degradation, not the stability of apolipoprotein II and vitellogenin II mRNAs in chick liver. Int. Council Sci. Unions Short Reports 4: 286–287.
Gorski, J., Toft, D. O., Shyamala, G., Smith, D., and Notides, A., 1968, Hormone receptors: Studies on the interaction of estrogen with the uterus, Rec. Prog. Horm. Res. 24: 4580.
Gorski, J., Welshons, W., and Sakai, D., 1984, Remodelling the estrogen receptor model, Mol. Cell. Endocrinol. 36: 11–15.
Goueli, S. A., and Ahmed, K., 1984, Phosphorylation of nuclear matrix proteins is under androgenic control, Arch. Biochem. Biophys. 234: 6640–6650.
Goy, R. W., 1981, Differentiation of male social traits in female rhesus macaques by prenatal treatment with androgens: Variation in type of androgen, duration and timing of treatment, in: Fetal Endocrinology ( M. J. Novy and J. A. Resko. eds.), p. 319, Academic Press, New York.
Goy, R. W., and Phoenix, C. H., 1972, The effects of testosterone propionate administered before birth on the development of behavior in genetic female rhesus monkeys, in: Steroid Hormones and Brain Function ( C. A. Sawyer and R. Gorski, eds.), p. 193, University of California Press, Los Angeles.
Goy, R. W., and Resko, J. A., 1972, Gonadal hormones and behavior of normal and pseu- dohermaphroditic nonhuman female primates, Rec. Prog. Horrn. Res. 28: 707–733.
Granberg, J. P., and Ballard, P. L., 1977, The role of sulfhydryl groups in the binding of glucocorticoids by cytoplasmic receptors of lung and other mammalian tissues, Endocrinology 100: 1160–1168.
Grand, R. J., di Sant’Agnese, P. A., Talamo, R. C., Pallavicini, J. C., and Rich, K., 1967a, The effects of exogenous aldosterone on sweat electrolytes. I. Normal subjects, J. Pediatr. 70: 346–356.
Grand, R. J., di Sant’Agnese, P. A., Talamo, R. C., Pallavicini, J. C., and Rich, K., 1976b, The effects of exogenous aldosterone on sweat electrolytes. II. Patients with cystic fibrosis of the pancreas, J. Pediatr. 70: 357–368.
Green, S., Walter, P., Kumar, V., Krust, A., Bornert, J.-M., Argos, P., and Chambon, P., 1986, Human oestrogen receptor cDNA: Sequence, expression and homology to v-erbA, Nature 320: 134–139.
Greene, G. L., 1986, Analysis of estrogen and progesterone receptor structure and dynamics, Program of the 68th Annual Meeting of the Endocrine Society, June, p. 6 (Abstract).
Greene, G. L., Gilna, P., Waterfield, M., Baker, A., Hort, Y., and Shine, J., 1986, Sequence and expression of human estrogen receptor complementary DNA, Science 231: 1150–1154.
Griffin, J. E., 1979, Testicular feminization associated with a thermolabile androgen receptor in cultured fibroblasts, J. Clin. Invest. 64: 1624–1631.
Griffin, J. E., and Durrant, J. L., 1982, Qualitative receptor defects in families with androgen resistance: Failure of stabilization of the fibroblast cytosol androgen receptor, J. Clin. Endocrinol. Metab. 55: 465–474.
Griffin, J. E., and Wilson, J. D., 1980, The syndromes of androgen resistance, N. Engl. J. Med. 302: 198–209.
Griffin, J. E., Allman, D. R., Durrant, J. L., and Wilson, J. D., 1981, Variation in steroid 5a-reductase activity in cloned human skin fibroblasts, J. Biol. Chem. 256: 3662–3666.
Grippo, J. F., Holmagren, A., and Pratt, W. B., 1985, Proof that the endogenous, heat-stable glucocorticoid receptor-activating factor is thioredoxin, J. Biol. Chem. 260: 93–97.
Grossman, C. J., Nathan, P., Taylor, B. B., and Sholiton, L. J., 1979, Rat thymic dihydrotestosterone receptor: Preparation, location and physiochemical properties, Steroids 34: 539–553.
Grove, M. D., Spencer, G. F., Rohwedder, G. F., Nagabhushanam, M., Worley, J. F., Warthen, J. D., Jr., Steffens, G. L., Flippen-Anderson, J. L., and Cook, J. C., Jr., 1979, Brassinolide, a plant growth-promoting steroid isolated from Brassica napus pollen, Nature 281: 216–217.
Gruol, D. J., Dalton, D. K., and Bourgeois, S., 1984, Nuclear interaction of wild type and variant glucocorticoid receptors, J. Steroid Biochem. 20: 255–257.
Gustafsson, J.-A., Eneroth, P., Hokfett, T., Mode, A., Norstedt, G., and Skett, P., 1980, Central control of hepatic steroid metabolism and “lactogenic” receptor, J. Steroid Biochem. 12: 1–15.
Gustafsson, J.-A., Bakke, O., Carlstedt-Duke, J., Fuxe, K., Harfstrand, A., Okret, S., Poellinger, L., and Wikstrom, A.-C., 1986, Purification, oligomerism, regulation and localization of the glucocorticoid receptor, Int. Council Sci. Unions Short Reports 4: 238–241.
Gyorki, S., Warne, G. L., Khalid, B. A. K., and Funder, J. W., 1983, Defective nuclear accumulation of androgen receptors in disorders of sexual differentiation, J. Clin. Invest. 72: 819–925.
Hackney, J. F., 1980, A glucocorticoid receptor in fetal mouse: Its relationship to cleft palate formation, Teratology 21: 39–51.
Hamana, J., and Iwai, K., 1978, Glucocorticoid—receptor complex binds to nonhistone protein and DNA in rat liver chromatin, J. Biochem. (Tokyo) 83: 279–286.
Hargreave, T. B. (ed.), 1983, Male Infertility, Springer, New York.
Harmon, J. M., Schmidt, T. J., and Thompson, E. B., 1984, Molybdate-sensitive and molybdate-resistant activation-labile glucocorticoid-receptor mutants of the human lymphoid cell line CEM-C7, J. Steroid Biochem. 21: 277–236.
Harmon, J. M., Thompson, E. B., and Kaione, K. A., 1985, Analysis of glucocorticoidresistant human leukemic cells by somatic cell hybridization, Cancer Res. 45: 1587 1593.
Harrison, D. F., 1970, Hereditary haemorrhagic telangiectasia and oral contraceptives, Lancet 1: 721.
Harvey, W., Grahame, R., and Panayi, G. S., 1976a, Effect of steroid hormones on human fibroblasts in vitro. I. Glucocorticoid action on cell growth and collagen synthesis, Ann. Rheum. Dis. 33: 437–441.
Harvey, W., Grahame, R., and Panayi, G. S., 1976b, Effect of steroid hormones on human fibroblasts in vitro. II. Antagonism by androgens of cortisol-induced inhibition, Ann. Rheum. Dis. 35: 148–151.
Haseltine, F. P., and Ohno, S., 1981, Mechanisms of gonadal differentiation, Science 211: 1272–1278.
Haslam, S. Z., and Levely, M. L., 1985, Estrogen responsiveness of normal mouse mammary cells in primary cell culture: Association of mammary fibroblasts with estrogenic regulation of progesterone receptors, Endocrinology 116: 1835–1844.
Hasselquist, M. B., Goldberg, N., Schroeter, A., and Spelsberg, T. C., 1980, Isolation and characterization of the estrogen receptor in human skin, J. Clin. Endocrinol. Metab. 50: 76–82.
Hastie, N. D., Held, W. A., and Toole, J. J., 1979, Multiple genes coding for the androgen-regulated major urinary proteins of the mouse, Cell 17: 449–457.
Hawkins, E. F., Hutchens, T. W., Fligiel, S., Horn, D., and Markland, F. S., 1982. Glucocorticoids and melanoma: Receptor properties of dexamethasone sensitive and resistant tumors, J. Steroid Biochem. 16: 673–681.
Hembree, W. C., Fang, J. F., and Jagiello, G., 1977, Meiotic abnormalities in male reproductive dysfunction, in: The Testis in Normal and Infertile Men ( P. Troen and H. R. Nankin, eds.), pp. 25–29, Raven Press, New York.
Hendry, L. B., Muldoon, T. G., Bransome, E. D., Jr., Lehner, A. F., Hutson, M. S., Uberoi, N. K., Myers, R. B., Segaloff, A., and Mahesh, V. B., 1986, Predicting hormonal activity from the stereochemistry of nucleic acids: A prospective study with novel estrogenic steroids, Int. Council Sci. Unions Short Reports 4: 292–293.
Hendry, L. B., Bransome, E. D., Jr., Lehner, A. F., Muldoon, T. J., Hutson, M. S., Mahesh, V. B., 1986, The stereochemical complementarity of DNA and reproductive steroid hormones correlates with biological activity, J. Steroid Biochem. 24: 843–852.
Heuberger, B., Fitzka, I., Wasner, G., and Kratochwil, K., 1982, Induction of androgen receptor formation by epithelium—mesenchyme interaction in embryonic mouse mammary gland, Proc. Natl. Acad. Sci. USA 79: 2957–2961.
Heyde, E. C., 1954, Hereditary hemorrhagic telangiectasia: A report of pulmonary arteriovenous fistulae in mother and son: Medical (hormonal) and surgical therapy of this disease, Ann. Intern. Med. 41: 1042.
Hier, D. B., and Crowley, W. F., Jr., 1982, Spatial ability in androgen-deficient men, N. Engl. J. Med. 306: 1202–1205.
Hines, M., 1982, Prenatal gonadal hormones and sex differences in human behavior, Psycho(. Bull. 92: 56–80.
Hirst, M. A., Hochman, H. I., and Feldman, D., 1985, Vitamin D resistance and alopecia: A kindred with normal 1,25-dihydroxyvitamin D binding, but decreased receptor affinity for deoxyribonucleic acid, J. Clin. Endocrinol. Metab. 60: 490–495.
Hodgins, M. B., 1982, Binding of androgens in 5a-reductase-deficient human genital skin fibroblasts and its inhibition by progesterones, J. Endocrinol. 94: 415–428.
Hodgins, M. B., Duke, E. M. C., and Ring, D., 1984, Carrier detection in the testicular feminization syndrome: Deficient 5a-dihydrotestosterone binding in cultured skin fibroblasts from the mothers of patients with complete androgen insensitivity, J. Med. Genet. 21: 178–181.
Holbrook, N. J., Bodwell, J. E., Jeffries, M., and Munck, A., 1983, Characterization of nonactivated and activated glucocorticoid—receptor complexes from intact rat thymus cells, J. Biol. Chem. 258: 6477–6485.
Holbrook, N. J., Bodwell, J. E., and Munck, A., 1984, Nonactivated and activated glucocorticoid—receptor complexes in WEHI-7 and rat thymus cells, J. Steroid Biochem. 20: 19–22.
Hollenberg, S. M., Weinberger, C., Ong, E. S., Cerelli, G., Oro, A., Lebo, R., Thompson, B., Rosenfeld, M. G., and Evans, R. M., 1985, Primary structure and expression of a functional human glucocorticoid receptor cDNA, Nature 318: 635–641.
Horgen, P. A., 1981, The role of steroid sex pheromone antheridiol in controlling the development of male sex organs in the water mold, Achyla, in: Sexual Interactions in Eukarvotic Microbes ( D. H. O’Day and P. A. Horgen. eds.), pp. 155–178, Academic Press, New York.
Horwitz, K. B., and McGuire, W. L., 1980, Nuclear estrogen receptors. Effect of inhibitors on processing and steady siate levels, J. Biol. Chem. 255: 9699–9705.
Housley, P. R., and Pratt, W. B., 1983, Direct demonstration of glucocorticoid receptor phosphorylation by mouse L cells, J. Biol. Chem. 258: 4630–4635.
Housley, P. R., Dahmer, M. K., and Pratt, W. B., 1982, Inactivation of glucocorticoidbinding capacity by protein phosphatases in the presence of molybdate and complete reactivation by dithiothreitol, J. Biol. Chem. 257: 8615–8618.
Housley, P. R., Sanchez, E. R., Westphal, H. M., Beato, M.. and Pratt, W. B., 1985, The molybdate-stabilized L-cell glucocorticoid receptor isolated by affinity chromatography or with a monoclonal antibody is associated with a 90–92-kDa nonsteroid-binding phosphoprotein, J. Biol. Chem. 260: 13810–13817.
Hughes, I. A., and Evans, B. J. A., 1984, Application of a simple receptor assay to study androgen action in the androgen insensitivity syndrome, in: Seventh International Congress of Endocrinology, p. 920 ( Abstract), Quebec City, Quebec, Canada.
Ichii, S., Izawa, M., and Murakami, N., 1974, Hormonal regulation of protein synthesis in rat ventral prostate, Endocrinol. Jpn. 21: 267–274.
Iida, S., Gomi, M., Moriwaki, K., Itoh, Y., Hirobe, K., Matsuzawa, Y., Katagiri, S., Yonezawa, T., and Tarui, S., 1985, Primary cortisol resistance accompanied by a reduction in glucocorticoid receptors in two members of the same family, J. Clin. Endocrinol. Metab. 60: 967–971.
Imperato-McGinley, J., 1983, Sexual differentiation: Normal and abnormal, Curr. Top. Exp. Endocrinol. 5:232–307.
Imperato-McGinley, J., Guerrero, L., Gautier, T., and Peterson, R. E., 1974, Steroid 5areductase deficiency in man: An inherited form of male pseudohermaphroditism, Science 186:1213–1215.
Imperato-McGinley, J., Peterson, R. E., Gautier, T., and Sturla, E., 1979, Androgens and the evolution of male-gender identity among male pseudohermaphrodites with 5a-reductase deficiency, N. Engl. J. Med. 300: 1233–1237.
Imperato-McGinley, J., Peterson, R. E., Leshin, M., Griffin, J. E., Cooper, G., Draghi, S., Berenyi, M., and Wilson, J. D., 1980, Steroid 5a-reductase deficiency in a 65-year-old male pseudohermaphrodite: The natural history, ultrastructure of the testes, and evidence for inherited enzyme heterogeneity, J. Clin. Endocrinol. Metab. 50: 15–22.
Imperato-McGinley, J., Peterson, R. G., Gauthier, T., Cooper, G., Danner, R., Arthur, A., Morris, P. L., Sweeney, W. J., and Shackelton, C., 1982, Hormonal evaluation of a large kindred with complete androgen insensitivity: Evidence for secondary 5a-reductase deficiency, J. Clin. Endocrinol. Metab. 54: 931–941.
Imperato-McGinley, J., Peterson, R. E., Gautier, T., Arthur, A., and Shackelton, C., 1985, Decreased urinary C19 and C21 steroid 5a-metabolites in parents of male pseudohermaphrodites with 5a-reductase deficiency: Detection of carriers, J. Clin. Endocrinol. Metab. 60: 553–558.
Inglis, J., and Lawson, J. S., 1981, Sex differences in the effects of unilateral brain damage on intelligence, Science 212: 693–695.
Inman, R. D., Jovanovic, L., Markenson, J. A., Longcope, C., Dawood, Y., and Lockshin, M. D., 1982, Systemic lupus erythematosis in man: Genetic and endocrine features, Arch. Intern. Med. 142: 1813–1815.
Isohashi, F., Horiuchi, M., Okamoto, K., and Sakamoto, Y., 1984, Separation and characterization of receptor-translocation inhibitors from AH130 tumor cells, J. Steroid Biochem. 20: 1117–1122.
Jänne, O. A., and Bardin, C. W., 1984, Androgen and antiandrogen receptor binding, Annu. Rev. Physiol. 46: 107–118.
Jensen, E. V., 1984, Intracellular localization of estrogen receptors: Implications for interaction mechanism, Lab. Invest. 51: 487–488.
Jensen, E. V., Suzuki, T., Kawashima, T., Stumpf, W. E., Jungblut, P. W., and DeSombre, E. R., 1968, A two step mechanism for the interaction of estradiol with rat uterus, Proc. Natl. Acad. Sci. USA 59: 632–638.
Joab, I., Radanyi, C., Renoir, M., Buchou, T., Catelli, M.-G., Binart, N., Mester, J., and Baulieu, E.-E., 1984, Common non-hormone binding component in non-transformed chick oviduct receptors of four steroid hormones, Nature 308: 850–853.
Johnson, D. M., Newby, R. F., and Bourgeois, S., 1984, Membrane permeability as a determinant of dexamethasone resistance in murine thymoma cells, Cancer Res. 44: 2435–2440.
Jordan, C. L., Breedlove, S. M., and Arnold, A. P., 1982, Sexual dimorphism and the influence of neonatal androgen in the dorsolateral motor nucleus of the rat lumbar spinal cord, Brain Res. 249: 309–314.
Josso, N., Picard, J. Y., and Tran, D., 1977, The antimullerian hormone, Rec. Prog. Horm. Res. 33: 117–160.
Jost, J.-P., Seldran, M., and Geiser, M., 1984, Preferential binding of estrogen—receptor complex to a region containing the estrogen-dependent hypomethylation site preceding the chicken vitellogenin II gene, Proc. Natl. Acad. Sci. USA 81: 429–433.
Judge, S. M., Phillips, M. M., and Liao, S., 1984, Analysis of androgen-sensitivity in rat prostate x mouse kidney cell hybrids, Exp. Cell Res. 153: 145–157.
Jukier, L., Kaufman, M., Pinsky, L., and Peterson, R. E., 1984, Partial androgen resistance associated with secondary 5a-reductase deficiency: Identification of a novel qualitative androgen receptor defect and clinical implications, J. Clin. Endocrinol. Metab. 59: 679–688.
Junker, K., 1983, Glucocorticoid receptors of human mononuclear leukocytes in vitro, J. Clin. Endocrinol. Metab. 57: 506–512.
Kahn, C. R., 1978, Insulin resistance, insulin insensitivity, and insulin unresponsiveness: a necessary distinction, Metabolism 27: 1893–1902.
Kandala, J. C., Kistler, M. K., and Kistler, W. S., 1985, Androgen regulated genes from prostate and seminal vesicle share upstream sequence homologies, Biochem. Biophys. Res. Commun. 126: 948–952.
Karin, M., Eberhardt, N. L., Mellon, S. H., Malich, N., Richards, R. I., Slater, E. P., Barta, A., Martial, J. A., Baxter, J. D., and Cathala, G., 1984a, Expression and hormonal regulation of the rat growth hormone gene in transfected mouse L cells, DNA 3: 147–155.
Karin, M., Haslinger, A., Holtgreve, H., Cathala, G., Slater, E., and Baxter, J. D., 1984b, Activation of heterologous promoter in response to dexamethasone and cadmium by metallothionein gene 5’-flanking DNA, Cell 36: 371–379.
Karin, M., Haslinger, A., Holtgreve, H., Richards, R. I., Krauter, P., Westphal, H. M., and Beato, M., I984c, Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein-IIA gene, Nature 308:513519.
Karlson, P., 1983, Eighth Adolf Butenandt Lecture: Why are so many hormones steroids?, Hoppe-Seyler’s Z. Physiol. Chem. 364: 1067–1087.
Katsumata, M., Baker, M. K., and Goldman, A. S., 1981, An H-2 linked difference in the binding of dexamethasone to murine hepatic cytosol receptor, Biochim. Biophys. Acta 676: 245–256.
Kaufman, M., and Pinsky, L., 1983, The dissociation of testosterone— and 5a-dihydrotestosterone—receptor complexes formed within cultured human genital skin fibroblasts, J. Steroid Biochem. 18: 121–125.
Kaufman, M., Pinsky, L., Straisfeld, C., Shanfield, B., and Zilahi, B., 1975, Qualitative differences in testosterone metabolism as an indication of cellular heterogeneity in fibroblast monolayers derived from human preputial skin, Exp. Cell Res. 96: 31–36.
Kaufman, M., Straisfeld, C., and Pinsky, L., 1976, Male pseudohermaphroditism presumably due to target organ unresponsiveness to androgens: Deficient Sa-dihydrotestosterone binding in cultured skin fibroblasts, J. Clin. Invest. 58: 345–350.
Kaufman, M., Straisfeld, C., and Pinsky, L., 1977, Expression of androgen-responsive properties in human skin fibroblast strains of genital and nongenital origin, Somat. Cell Genet. 3: 17–25.
Kaufman, M., Pinsky, L., Simard, L., and Wong, S. C., 1982a, Defective activation of androgen—receptor complexes: A marker of androgen insensitivity, Mol. Cell. Endocrinol. 25: 151–162.
Kaufman, M., Pinsky, L., Wong, S. C., Simard, L., and Dorato, A., 1982b, Sodium thiocyanate: A probe for the conformations of the androgen—receptor complex, Mol. Cell. Endocrinol. 27: 121–128.
Kaufman, M., Pinsky, L., Hollander, R., and Bailey, J. D., 1983a, Regulation of the androgen receptor by androgen in normal and androgen-resistant genital skin fibroblasts, J. Steroid. Biochem. 18: 383–390.
Kaufman, M., Pinsky, L., Schwartz, A., and Long-Simpson. L., 1983b, Possible implications of the comparative dissociative behavior of testosterone— and 5a-dihydrotestosterone—receptor complexes formed by human skin fibroblasts, J. Steroid Biochem. 19: 561–565.
Kaufman, M., Pinsky, L., Brown, A., and Au, M. W. S., 1984a, Familial external ambiguity due to a transformation defect of androgen—receptor complexes that is expressed with 5a-dihydrotesterone and the synthetic androgen, methyltrienolone, Am. J. Med. Genet. 18: 493–507.
Kaufman, M., Pinsky, L., and Killinger, D. W., 1986, Ligand-selective thermal misbehavior of synthetic androgen—receptor complexes in genital skin fibroblasts of subjects with familial ligand-sensitive androgen resistance, J. Steroid Biochem. 25:(in press).
Kaufmann, S. H., and Shaper, J. H., 1984, Binding of dexamethasone to rat liver nuclei in vivo and in vitro: Evidence for two distinct binding sites, J. Steroid Biochem. 20: 699–708.
Keenan, B. S., Meyer, W. J., III, Hadjian, A. J., Jones, H. W., and Migeon, C. J., 1974, Syndrome of androgen insensitivity in man: Absence of 5a-dihydrotestosterone binding protein in skin fibroblasts, J. Clin. Endocrinol. Metab. 38: 1143–1146.
Keenan, B. S., McNeil, R. L., and Gonzales, E. T., 1984, Abnormality of intracellular 5adihydrotestosterone binding in simple hypospadias: Studies on equilibrium steroid binding in sonicates of genital skin fibroblasts, Pediatr. Res. 18: 216–220.
Keene, J. L., Sweet, F., Ruh, M. F., and Ruh, T. S., 1984, Interaction of the radiolabelled high-affinity anti-estrogen [3H]H1285 with cytoplasmic oestrogen receptor, Biochem. J. 217: 819–826.
Keller, D. W., Wiest, W. G., Askin, F. B., Johnson, L. W., and Strickler, R. C., 1979, Pseudocorpus luteum insufficiency: A local defect of progesterone action on endometrial stroma, J. Clin. Endocrinol. Metab. 48: 127–132.
Kidd, K. K., 1985, The search for the ultimate cause of maleness, N. Engl. J. Med. 313: 260–261
Kidson, C., Thomas, A., and Cohen, P., 1970, Interactions of hormonal steroids with nucleic acids. III. Role of polymer structure, Biochemistry 9: 1571–1576.
Kiel-Metzger, K., Warren, G., Wilson, G., and Erickson, R. P.. 1985, Evidence that the human Y chromosome does not contain clustered DNA sequences (BKM) associated with heterogametic sex determination in other vertebrates. N. Engl. J. Med. 313: 342–345.
King, W., and Greene, G. L., 1984, Monoclonal antibodies localize estrogen receptor in the nuclei of target cells, Nature 307: 745–747.
Kitzsteiner, K. A., and Mallen, R. C., 1980, Pulmonary lymphangiomyomatosis treated with castration, Cancer 46: 2248–2249.
Klosterman, L. L., Murai, J. T., and Siiteri, P. K., 1986, Cortisol levels, binding, and properties of corticosteroid-binding globulin in the serum of primates, Endocrinology 118: 424–434.
Klyzsejko-Stefanowicz, L., Chiu, J.-F., Tsai, Y.-H., and Hnilica, L. S., 1976, Acceptor proteins in rat androgenic tissue chromatin, Proc. Natl. Acad. Sci. USA 73: 1954–1958.
Knowles, M. R., Gatzy, J. T., and Boucher, R. C., 1985, Aldosterone metabolism and transepithelial potential difference in normal and cystic fibrosis subjects, Pediatr. Res. 19: 676–679.
Koch, H. J., Escher, G. C., and Lewis, J. S., 1952, Hormonal management of hereditary hemorrhagic telangiectasia, J. Am. Med. Assoc. 149: 1376.
Kofoed, J. A., 1971, Concentration and synthesis of acidic glycosaminoglycans in gingiva of normal and orchidectomized rats injected with testosterone, J. Periodont. Res. 6:278–281.
Kofoed, J. A., Bozzini, C. E., and Tocci, A. A., 1970, The concentration and synthesis of glycosaminoglycans in the skin and tracheal cartilage of normal and orchidectomized rats injected with testosterone, Acta Endocrinol. (Copenhagen) 63: 193–198.
Kontula, K., Pelkonen, R., Andersson, L., and Sivula, A., 1980, Glucocorticoid receptor in adrenocorticoid disorders, J. Clin. Endocrinol. Metab. 51: 654–657.
Kontula, K. K., Torkkeli, T. K., Bardin, C. W., and Jänne, O. A., 1984, Androgen induction of ornithine decarboxylase mRNA in mouse kidney as studied by complementary DNA, Proc. Natl. Acad. Sci. USA 81: 731–735.
Kontula, K. K., Seppanen, P. J., van Duyne, P., Bardin, C. W., and Jänne, O. A., 1985, Effect of a nonsteroidal antiandrogen, flutamide, on androgen receptor dynamics and ornithine decarboxylase gene expression in mouse kidney, Endocrinology 116: 226–233.
Koolman, J., 1982, Ecdysone metabolism, Insect. Biochem. 12: 225–250.
Kovacs, W. J., Griffin, J. E., Weaver, D. D., Carlson, B. R., and Wilson, J. D., 1984, A mutation that causes lability of the androgen receptor under conditions that normally promote transformation to the DNA-binding state, J. Clin. Invest. 73: 1095–1104.
Kratochwil, K., and Schwartz, P., 1976, Tissue interaction in androgen response of embryonic mammary rudiment of mouse: Identification of target tissue of testosterone, Proc. Natl. Acad. Sci. USA 73: 4041–4044.
Krozowski, Z. S., and Murphy, L. C., 1981, Stabilization of the cytoplasmic estrogen receptor by molybdate, J. Steroid Biochem. 14: 363–366.
Kruskemper, H. L., and Noe11, G., 1966, Liver toxicity of a new anabolic agent: Methyltrienolone (17a-methyl-4,9,11,estratriene-17ß-ol-3-one), Steroids 8: 13–24.
Kuhnle, U., Keller, U., Schroeter, Ch., Knorr, D., and Armanini, D., 1986, Autosomal recessive and dominant mode of inheritance in two families with pseudohypoaldosteronism (PHA): Evidence for different mineralocorticoid effector mechanisms, Program of the 68th Annual Meeting of the Endocrine Society, June. p. 221 (Abstract #760).
Kurz, J. B., Perkins, J. P., and Buchwald, J. P., 1979, Killing of fibroblasts by dexamethasone or dibutyryl adenosine 3’,5’-monophosphate is not a valid test for cystic fibrosis, Science 206: 1317–1319.
Kuttenn, F., and Mauvais-Jarvis, P., 1975, Testosterone 5a-reduction in the skin of normal subjects and of patients with abnormal sex development, Acta Endocrinol. 79: 164–176.
Kuttenn, F., Mowszowicz, I., Schaison, G., and Mauvais-Jarvis, P., 1977, Androgen production and skin metabolism in hirsutism, J. Endocrinol. 75: 83–91.
Kuttenn, F., Couillin, P., Firard, F., Baillaud, L., Vincens, M., Boucekkine, C., Thalabard, J.-C., Maudelonde, T., Spritzer, P., Mowszowicz, I., Boué, A., and Mauvais-Jarvis, P., 1985, Late-onset adrenal hyperplasia in hirsutism, N. Engl. J. Med. 313: 224–231.
Lambrigts, G., Dierickx, P., De Moor, P., and Verhoeven, G., 1979, Comparison of the metabolism and receptor binding of testosterone and l713-hydroxy-5a-androstan-3-one in normal skin fibroblast cultures: Influence of origin and passage number, J. Clin. Endocrinol. Metab. 48: 924–930.
Lanari, A., 1983, Effect of progesterone on desmoid tumors (aggressive fibromatosis), N. Engl. J. Med. 309: 1523.
Larrea, F., Benavides, G., Scaglia, H., Kofman-Alfaro, S., Perrusca, E., Medina, M., and Perez-Palacios, G., 1978, Gynecomastia as a familial incomplete male pseudohermaphroditism type 1: A limited androgen resistance syndrome, J. Clin. Endocrinol. Metab. 46: 961–970.
Lasnitzki, I., and Mizuno, T., 1979, Role of the mesenchyme in the induction of the rat prostate gland by androgens in organ culture, J. Endocrinol. 82: 171–178.
Leach, K. L., Dahmer, M. K., Hammond, N. D., Sando, J. J., and Pratt, W. B., 1979, Molybdate inhibition of glucocorticoid—receptor inactivation and transformation, J. Biol. Chem. 254: 11884–11890.
Leach, K. L., Grippo, J. F., Housley, P. R., Dahmer, M. K., Salive, M. E., and Pratt, W. G., 1982, Characteristics of an endogenous glucocorticoid—receptor stabilizing factor, J. Biol. Chem. 257: 381–388.
Lefebvre, Y. A., and Novosad, Z., 1980, Binding of androgens to a nuclear-envelope fraction from the rat ventral prostate, Biochem. J. 186: 641–647.
Lefebvre, Y. A., Golsteyn, E. J., and Michiel, T. L., 1985a, Androgen interactions with intact nuclear envelopes from the rat ventral prostate, J. Steroid Biochem. 23: 107–113.
Lefebvre, Y. A., Howell, G. M., and Golsteyn, E. J., 1985b, Androgen interactions with the nuclear envelope, in: Regulation of Androgen Action (N. Bruchovsky, A. Chapdelaine. and F. Neumann, eds.), pp. 155–158, Congressdruck R. Bruckner, Berlin.
Lehner, A. F., 1986, Physicochemical studies suggest that steroid hormone action may involve insertion of steroids between base pairs in DNA, Program of the 68th Annual Meeting of the Endocrine Society, June, p. 72 (Abstract #75).
Lehner, A. F., Muldoon, T. G., Mahesh, V. B., Bransome, E. D., Jr., and Hendry, L. B., 1986, The phytoestrogen coumestrol appears capable of insertion between base pairs in DNA in agreement with a stereochemical rationale for hormone action, Int. Council Sci. Unions Short Reports 4: 304–305.
Levy, J., and Levy, J. M., 1978, Human lateralization from head to foot: Sex-related factors, Science 200: 1291–1292.
Liang, T., and Liao, S., 1975, A very rapid effect of androgen on initiation of protein synthesis in prostate, Proc. Natl. Acad. Sci. USA 72: 707–709.
Liang, T., Tymoczko, J. L., Chan, K. M. B., Hung, S. C., and Liao, S., 1977, Androgen action-Receptors and rapid responses, in: Androgens and Antiandrogens ( L. Martini and M. Motta, eds.), pp. 77–89, Raven Press, New York.
Liao, S., 1965, Influence of testosterone on template activity of prostatic ribonucleic acids, J. Biol. Chem. 240: 1236–1243.
Liao, S., Liang, T., and Tymoczko, J. L., 1973a, Ribonucleoprotein binding of steroid—“receptor” complexes, Nature New Biol. 241: 211–213.
Liao, S., Liang, T., Fang, S., Castaneda, E., and Shao, T.-C., 1973b, Steroid structure and androgenic activity: Specifications involved in the receptor binding and nuclear retention of various androgens, J. Biol. Chem. 248: 6154–6162.
Liao, S., Smythe, S., Tymoczko, J. L., Rossini, G. P., Chen, C., and Hiipakka, R. A., 1980, RNA-dependent release of androgen— and other steroid—receptor complexes from DNA, J. Biol. Chem. 255: 5545–5551.
Liac, S., Chen, C., and Huang, 1.-Y., 1982, Prostate a-protein: Complete amino acid sequence of the component that inhibits nuclear retention of androgen—receptor complex, J. Biol. Chem. 257: 122–125.
Liao, S., Chang, C., Witte, D., Saltzman, A., and Hiipakka, R. A., 1985, Modulation of androgen receptor and androgen-dependent enhancement and repression of protein synthesis, in: Regulation of Androgen Action ( N. Bruchovsky, A. Chapdelaine, and F. Neumann, eds.), pp. 149–154, Congressdruck R. Bruckner, Berlin.
Liberman, U. A., Eil, C., Holst, P., Rosen, J. F., and Marx, S. J., 1983a, Hereditary resistance of 1,25-dihydroxyvitamin D: Defective function of receptors for 1,25-dihydroxyvitamin D in cells cultured from bone, J. Clin. Endocrinol. Metab. 57: 958–962.
Liberman, U. A., Eil, C., and Marx, S. J., 1983b, Resistance to 1,25-dihydroxyvitamin D: Association with heterogeneous defects in cultured skin fibroblasts, J. Clin Invest. 71: 192–200.
Liberman, B. A., Chamberlain, D. W., and Goldstein, R. S., 1984, Tuberous sclerosis with pulmonary involvement, Can. Med. Assoc. J. 130: 287–289.
Limai, J. M., Rappaport, R., Dechaux, M., and Morin, C., 1978, Familial dominant pseudohypoaldosteronism, Lancet 1: 51.
Lin, S.-Y., and Ohno, S., 1981, The binding of androgen receptor to DNA and RNA, Biochim. Biophys. Acta 654: 181–186.
Liu, S.-L., and Webb, T. E., 1977, Elevated concentration of a dexamethasone-receptor translocation inhibitor in Novikoff hepatoma cells, Cancer Res. 37: 1763–1767.
Lobeck, C. C., and McSherry, N. R., 1963, Response of sweat electrolyte concentrations to 9 alpha-fluorohydrocortisone in patients with cystic fibrosis and their families, J. Pediatr. 62: 393–398.
Lobi, T. J., Campbell, J. A., Trudall, D. J., Cunningham, G. R., and Means, A. R., 1980, A model for the mechanism of androgen binding, transport, and translocation to the nucleus, in: Testicular Development, Structure and Function ( A. Steinberger and E. Steinberger, eds.), pp. 323–330, Raven Press, New York.
Loire, C., Kern, B., and Sultan, C., 1984, Action of androgen on fibroblast collagen synthesis: A receptor-dependent response, Pediatr. Res. 18: 1230 (Abstract).
Loosfelt, H., Atger, M., Logeat, F., and Milgrom, E., 1986, Cloning of rabbit progesterone receptor complementary DNA, Program of the 68th Annual Meeting of the Endocrine Society, June, p. 138 (Abstract #430).
Lorenzo, E. M., 1970, Familial study of hirsutism, J. Clin. Endocrinol. Metab. 31: 556–564.
Lowy, M. T., Reder, A. T., Antel, J. P., and Meltzer, H. Y., 1984, Glucocorticoid resistance in depression: The dexamethasone suppression test and lymphocyte sensitivity to dex-amethasone, Am. J. Psychiatry 141: 1365–1370.
Lowy, M. T., Reder, A. T., and Meltzer, H. Y., 1985, Hypercortisolism and depression, N. Engl. J. Med. 312: 791.
Luttge, W. G., Gray, H. E., and Densmore, C. L., 1984, Hydrodynamic and biochemical correlates of the activation of the glucocorticoid–receptor complex, J. Steroid Biochem. 20: 545–558.
Lyon, M. F., and Glenister, P. H., 1974, Evidence from Tfm/O that androgen is inessential for reproduction in female mice, Nature 247: 366–367.
Lyon, M. F., and Glenister, P. H., 1980, Reduced reproductive performance in androgen-resistant Tfm/Tfm mice, Proc. R. Soc. Lond. 208: 1–12.
Lyon, M. F., and Hawkes, S. G., 1970, An X-linked gene for testicular feminization in the mouse, Nature 227: 1217–1219.
Lyon, M. F., Hendry, I., and Short, R. V., 1973, The submaxillary salivary glands as test organs for response to androgen in mice with testicular feminization, J. Endocrinol. 58: 357–362.
Lyon, M. F., Glenister, P. H., and Lamoureux, M. L., 1975, Normal spermatozoa from androgen-resistant germ cells of chimaeric mice and the role of androgen in spermatogenesis, Nature 258: 620–622.
Maccoby, E. E., and Jacklin, C. N., 1974, The Psychology of Sex Differences, University Press, Stanford.
Madden, J. D., Walsh, P. C., MacDonald, P. C., and Wilson, J. D., 1975, Clinical and endocrinologic characterization of a patient with the syndrome of incomplete testicular feminization, J. Clin. Endocrinol. Metab. 41: 751–760.
Maes, M., Sultan, C., Zerhouni, N., Rothwell, S. W., and Migeon, C. J., 1979, Role of testosterone binding to the androgen receptor in male sexual differentiation of patients with 5a-reductase deficiency, J. Steroid Biochem. 11: 1385–1390.
Maggi, A., Schrader, W. T., and O’Malley, B. W., 1984, Progesterone-binding sites of the chick oviduct receptor, J. Biol. Chem. 259: 10956–10966.
Mainwaring, W. I. P., Mangan, F. R., and Peterken, B. M., 1971, Studies on the solubilized ribonucleic acid polymerase from rat ventral prostate gland, Biochem. J. 123: 619–628.
Martini, L., 1982, The 5a-reduction of testosterone in the neuroendocrine structures. Biochemical and physiological implications, Endocr. Rev. 3: 1–25.
Marver, D., 1980, Aldosterone receptors in rabbit renal cortex and medulla, Endocrinology 106: 611–618.
Matthay, R. A., Bromberg, S. I., and Putman, C. E., 1980, Pulmonary–renal syndromes—A review, Yale J. Biol. Med. 53: 497–523.
Maurer, R. A., 1985, Selective binding of the estradiol receptor to a region at least one kilobase upstream from the rat prolactin gene, DNA 4: 1–9.
Max, S. R., 1981, Cytosolic androgen receptor in skeletal muscle from normal and testicular feminization mutant (Tfm) rats, Biochem. Biophys. Res. Commun. 101: 792–799.
Mayo, K. E., 1986, Structure and expression of hypothalamic GRF and CRF genes. Program of the 68th Annual Meeting of the Endocrine Society. June, p. 30 (Abstract #11).
McBlain, W. A., Toft, D. A., and Shyamala, G., 1981, Transformation of mammary cytoplasmic glucocorticoid receptor under cell-free conditions, Biochemistry 20: 6790–6798.
McCarty, K. S., Jr., Mossier, J. A., McLelland, R., and Sicker, H. O., 1980, Pulmonary lymphangiomyomatosis responsive to progesterone, N. Engl. J. Med. 303: 1461–1465.
McCarty, K. S., Jr., Mossier, J. A., McLelland, R., and Sicker, H. O., 1981a, Pulmonary lymphangiomyomatosis, N. Engl. J. Med. 304: 978–979.
McCarty, K. S., Jr., Mossier, J. A., McLelland, R., and Sicker. H. O., 1981b, Pulmonary lymphagiomyomatosis and metastasizing leiomyoma, N. Engl. J. Med. 305: 587–588.
McEwan, B. S., 1982, Sexual differentiation of the brain: Gonadal hormone action and current concepts of neuronal differentiation, in: Molecular Approaches to Neurobiology (I. Brown, ed.), pp. 195–219, Academic Press, New York.
McGill, H. C., Jr., Anselmo, V. C., Buchanan, J. M., and Sheridan, P. J., 1980, The heart is a target organ for androgen, Science 207: 775–777.
McGinnis, W., Levine, M. S., Hafen, E., Kuroiwa, A., and Gehring. W. J., 1984, A conserved DNA sequence in homoeotic genes of the Drosophila antennapedia and bithorax complexes, Nature 308: 428–433.
McIntyre, W. R., and Samuels, H. H., 1985, Triamcinolone acetonide regulates glucocorticoid-receptor levels by decreasing the half-life of the activated nuclear-receptor form, J. Biol. Chem. 260: 418–427.
McKenna, T. J., Moore, A., Magee, F., and Cunningham, S., 1983, Amenorrhea with cryptic hyperandrogenemia, J. Clin. Endocrinol. Metab. 56: 893–896.
McKnight, G. S., and Palmiter, R. D., 1979, Transcriptional regulation of the ovalbumin and conalbumin genes by steroid hormones in the chick oviduct, J. Biol. Chem. 254: 9050–9058.
McKnight, G. S., Hager, L., and Palmiter, R. D., 1980, Butyrate and related inhibitors of histone deacetylation block the induction of egg white genes by steroid hormones, Cell 257: 2591–2598.
McNeal, J. E., 1985, Morphology and biology of benign prostatic hyperplasia, in: Regulation of Androgen Action ( N. Bruchovsky, A. Chapdelaine, and F. Neumann, eds.), pp. 2330, Congressdruck R. Bruckner, Berlin.
Meaney, M. J., and Stewart, J., 1981a, A descriptive study of social development in the rat (Rattus norvegicus). Anim. Behay. 15: 197–213.
Meaney, M. J., and Stewart, J., 1981b, Neonatal androgens influence the social play of prepubescent rats, Horm. Behay. 15: 197–213.
Meaney, M. J., Stewart, J., and Beatty, W. W., 1982, The influence of glucocorticoids during the neonatal period on the development of play-fighting in Norway rat pups, Horm. Behay. 16: 475–491.
Meaney, M. J., Stewart, J., Poulin, P., and McEwen, B. S., 1983. Sexual differentiation of social play in rat pups is mediated by the neonatal androgen—receptor system, Neuroendocrinology 37: 85–90.
Meltzer, H. Y., Fang, V. S., Tricou, B. J., Robertson, A., and Piyaka, S. K., 1982, Effect of dexamethasone on plasma prolactin and cortisol levels in psychiatric patients, Am. J. Psychiatry 139: 763–768.
Menon, M., Tananis, C. E., Hicks, L. L., Hawkins, E. F., McLoughlin, M. G., and Walsh, P. C., 1978, Characterization of the binding of a potent synthetic androgen, methyltrienolone, to human tissues, J. Clin. Invest. 61: 150–162.
Meyer, W. J., III, Migeon, B. R., and Migeon, C. J., 1975, Locus on human X chromosome for dihydrotestosterone receptor and androgen insensitivity. Proc. Natl. Acad. Sci. USA 72: 1469–1472.
Miesfeld, R., Okret, S., Wikström, A.-C., Wrange, O., Gustafsson, J.-A., and Yamamoto, K. R., 1984, Characterization of a steroid hormone receptor gene and mRNA in wild-type and mutant cells, Nature 312: 779–781.
Migeon, B. R., Brown, T. R., Axelman, J., and Migeon, C. J., 1981, Studies of the locus for androgen receptor: Localization on the human X chromosome and evidence for homology with the Tfm locus in the mouse, Proc. Natl. Acad. Sci. USA 78: 6339–6343.
Milgrom, E., and Atger, M., 1975, Receptor translocation inhibitor and apparent saturability of the nuclear acceptor, J. Steroid Biochem. 6: 487–492.
Miller, M. A., Lippman, M. E., and Katzenellenbogen, B. S., 1984, Antiestrogen binding in antiestrogen growth-resistant estrogen-responsive clonal variants of MCF-7 human breast cancer cells, Cancer Res. 44: 5038–5045.
Miller, P. A., Ostrowski, M. C., Hager, G. L., and Simons, S. S., Jr., 1984, Covalent and noncovalent receptor—glucocorticoid complexes preferentially bind to the same regions of the long terminal repeat of murine mammary tumor virus proviral DNA, Biochemistry 23: 6883–6889.
Mitchell, G. W., 1979, Sex Differences in Primate Social Behavior, Holt, Rinehartand Winston, New York.
Mockus, M. B., and Horwitz, K. B., 1983, Progesterone receptors in human breast cancer, J. Biol. Chem. 258: 4778–4783.
Moguilewsky, M., and Philibert, D., 1984, RU-38486: Potent antiglucocorticoid activity correlated with strong binding to the cytosolic glucocorticoid receptor followed by an impaired activation, J. Steroid Biochem. 20: 271–276.
Moore, R. J., Griffin, J. E., and Wilson, J. D., 1975, Diminished 5a-reductase activity in extracts of fibroblasts cultured from patients with familial incomplete male pseudo-hermaphroditism, type 2, J. Biol. Chem. 250: 7168–7172.
Morishige, W. K., and Vetake, C. A., 1978, Receptors for androgen and estrogen in rat lung, Endocrinology 102: 1827–1837.
Morris, J. M., 1953, The syndrome of testicular feminization in male pseudohermaphroditism, Am. J. Obstet. Gynecol. 65: 1192–1211.
Morton, J. I., Weyant, D. A., Siegel, B. V., and Golding. B., 1981, Androgen sensitivity and autoimmune disease. I. Influence of sex and testosterone on the humoral immune response of autoimmune and non-autoimmune mouse strains to sheep erythrocytes, Immunology 44: 661–669.
Mowszowicz, I., Kirchhoffer, M.-O., Kuttenn, F., and Mauvais-Jarvis, P., 1980, Testosterone 5a-reductase activity in skin fibroblasts increase with serial subcultures, Mol. Cell. Endocrinol. 17: 41–50.
Mowszowicz, I., Riahi, M., Wright, F., Bouchard, P., Kuttenn, F., and Mauvais-Jarvis, P., 1981, Androgen receptor in human skin cytosol, J. Clin. Endocrinol. Metab. 52: 338–344.
Mowszowicz, I., Melanitou, E., Kirchhoffer, M.-O., and Mauvais-Jarvis, P., I983a, Dihydrotestosterone stimulates 5a-reductase activity in public skin fibroblasts, J. Clin. Endocrinol. Metab. 56: 320–325.
Mowszowicz, I., Melanitou, E., Doukani, A., Wright, F., Kuttenn, F., and Mauvais-Jarvis, P., 1983b, Androgen binding capacity and 5a-reductase activity in pubic skin fibroblasts from hirsute patients, J. Clin. Endocrinol. Metab. 56: 1209–1213.
Mulay, S., Finkelberg, R., Pinsky, L., and Solomon, S., 1973, Metabolism of 4–14C-testosterone by serially subcultured human skin fibroblasts, J. Clin. Endocrinol. Metab. 34: 133–143.
Mulder, E., Brinkmann, A. O., and de Boer, W., 1985, Characterization and partial purification of different forms of the androgen receptor and their interaction with DNA and RNA, in: Regulation of Androgen Action ( N. Bruchovsky, A. Chapdelaine, and F. Neumann, eds.), pp. 141–147, Congressdruck R. Bruckner, Berlin.
Müller, J., 1984, Morphometry and histology of gonads from twelve children and adolescents with the androgen insensitivity (testicular feminization) syndrome, J. Clin. Endocrinol. Metab. 59: 785–789.
Muller, R. E., Mrabett, N. T., Traish, A. M., and Wotiz, H. H., 1983, The role of arginyl residues in estrogen receptor activation and transformation, J. Biol. Chem. 258: 11582–11589.
Mullick, A., and Katzenellenbogen, B. S., 1986, Kinetic analysis of dense amino acid incorporation suggests a non-hormone binding precursor in progesterone receptor biosynthesis, Program of the 68th Annual Meeting of the Endocrine Society, June, p. 279 (Abstract #995).
Mulvihill, E. R., Le Pennec, J. P., and Chambon, P., 1982, Chicken oviduct progesterone receptor: Location of specific regions of high-affinity binding in cloned DNA fragments of hormone responsive genes, Cell 24: 621–632.
Munck, A., and Holbrook, N. J., 1984, Glucocorticoid—receptor complexes in rat thymus cells: Rapid kinetic behavior and a cyclic model, J. Biol. Chem. 259: 820–831.
Murai, J. T., Simberg, N. H., and Siiteri, P. K., 1986, The binding of sex steroids in male squirrel monkey, Program of the 68th Annual Meeting of the Endocrine Society, June, p. 48 (Abstract #71).
Murakami, T., Brandon, D., Rodband, P., Loriaux, D. L., and Lipsett, M. B., 1979, Glucocorticoid receptor in circulating mononuclear leukocytes, Endocrinology 104: 500–505.
Murray, J. C., Pollack, S. V., and Pinnell, S. R., 1981, Keloids: A review, J. Am. Acad. Dermatol. 4: 461–470.
Naess, O., Haug, E., Attramadal, A., Aakvaag, A., Hanson, V., and French, F., 1976, Androgen receptors in the anterior pituitary and central nervous system of the androgen “insensitive” (Tfm) rat: Correlation between receptor binding and effects of androgen on gonadotropin secretion, Endocrinology 99: 1295–1303.
Naftolin, F., and Judd, H. L., 1973, Testicular feminization, in: Obstetrics and Gynecology Annual, Vol. 2 ( R. M. Wynn, ed.), pp. 25–53, Appleton-Century-Crofts, New York.
New, M., Dupont, B., Grumbach, K., and Levine, L. S., 1983, Congenital adrenal hyperplasia and related conditions, in: The Metabolic Basis of Inherited Disease ( J. B. Stan-bury, J. B. Wyngaarden, D. S. Fredrickson, J. L. Goldstein, and M. S. Brown, eds.), pp. 973–1000, McGraw-Hill, New York.
Nielsen, A. C., and Torday, J. S., 1981, Sex differences in fetal rabbit pulmonary surfactant production, Pediatr. Res. 15: 1245–1247.
Nielsen, C. J., Sando, J. J., and Pratt, W. B., 1977, Evidence that dephosphorylation inactivates glucocorticoid receptors, Proc. Natl. Acad. Sci. USA 74: 1398–1402.
Nielsen, H. C., Zinman, H. M., and Torday, J. S., 1982, Dihydrotestosterone inhibits fetal rabbit pulmonary surfactant production, J. Clin. Invest. 69: 611–616.
Nordeen, E. J., and Yahr, P., 1982, Hemispheric asymmetries in the behavioral and hor- monal effects of sexually differentiating mammalian brain, Science 218: 391–394.
Nordeen, E. J., Nordeen, K. W., Sengelaub, D. R., and Arnold, A. P., 1985, Androgens prevent normally occurring cell death in a sexually dimorphic spinal nucleus, Science 299: 671–673.
Nordheim, A., and Rich, A., 1983, Negatively supercoiled simian virus 40 DNA contains Z-DNA segments within transcriptional enhancer sequences. Nature 303: 674–679.
Notides, A. C., Lerner, N., and Hamilton, D. E., 1981, Positive cooperativity of the estrogen receptor, Proc. Natl. Acad. Sci. USA 78: 4926–4930.
Oberfield, S. E., Levine, L. S., Carey, R. M., Bejar, R.. and New. M. I., 1979, Pseudohypoaldosteronism: Multiple target organ unresponsiveness to mineralocorticoid hormones, J. Clin. Endocrinol. Metab. 48: 228–234.
Ohara-Nemoto, Y., Nemoto, T., and Ota, M., 1986, Ribonucleic acid binding to androgen receptor in rat submandibular gland, Program of the 68th Annual Meeting of the Endocrine. Society, June, p. 208 (Abstract #710).
Okret, S., Carlstedt-Duke, J., Wrange, O., Carlström, K.. and Gustafsson, J.-A., 1981, Characterization of an antiserum against the glucocorticoid receptor, Biochim. Biophys. Acta 677: 205–219.
Ouwenel, W. J., 1976, Developmental genetics of homoeosis, Adv. Genet. 18: 179–248.
Ozasa, H., Tommaga, T., Nishimura, T., and Takeda, T., 1980, Radioautographic demonstration of dihydrotestosterone receptor in cultured human fibroblasts, Experientia 36: 1230–1232.
Ozasa, H., Tominaga, T., Nishimura, T., and Takeda, T., 1981, Evidence for receptor-dependent response to dihydrotestosterone in cultured human fibroblasts, Endokrinologie 77: 129–136.
Page, L. A., 1979, Inheritance of uncomplicated hypospadias, Pediatrics 63: 788–790.
Page, M. J., and Parker, M. G., 1983, Androgen regulated expression of a cloned rat prostatic C3 gene transfected into mouse mammary tumor cells, Cell 32: 495–502.
Paigen, K., 1979, Acid hydrolases as models of genetic control, Annu. Rev. Genet. 13: 417–466.
Palmiter, R. D., and Carey, N. H., 1974, Rapid inactivation of ovalbumin messenger ribonucleic acid after acute withdrawal of estrogen, Proc. Natl. Acad. Sci. USA 71: 2357–2361.
Payvar, F., DeFranco, D., Firestone, G. L., Edgar, B., and Wrange. O., 1983, Sequence-specific binding of glucocorticoid receptor to MTV DNA at sites within and upstream of the transcribed region, Cell 35: 381–392.
Pellikka, P. A., Sullivan, W. P., Coulam, C. B., and Toft. D. D.. 1983, Comparison of estrogen receptors in human premenopausal and postmenopausal uteri using isoelectric focusing, Obstet. Gynecol. 62: 430–434.
Perry, S. T., Viskochil, D. H., Jo, K.-C., Fong, K., Stafford, D. W., Wilson, E. M., and French, F. S., 1985, Androgen receptor binding to the C3(1) subunit gene of rat prostatein, in: Regulation of Androgen Action ( N. Bruchovsky, A. Chapdelaine, and F. Neumann, eds.), pp. 167–173, Congressdruck R. Bruckner, Berlin.
Person, J. R., and Longcope, C., 1984, Becker’s nevus: An androgen-mediated hyperplasia with increased androgen receptors, J. Am. Acad. Dermatol. 10: 235–238.
Peterkofsky, B., and Tomkins, G., 1968, Evidence for the steroid-induced accumulation of tyrosine aminotransferase mRNA in the absence of protein synthesis, Proc. Natl. Acad. Sci. USA 60: 222–228.
Peterson, R. E., Imperato-McGinley, J., Gautier, T., and Sturla, E., 1977, Male pseudohermaphroditism due to steroid 5a-reductase deficiency, Am. J. Med. 62: 170–191.
Pettersson, G., and Bonnier, G., 1937, Inherited sex-mosaic in man. Hereditas 23: 49–69.
Pierce, J. A., and Hocott, J. B., 1960, Studies on the collagen and elastin content of the human lung, J. Clin. Invest. 39: 8–14.
Pietras, R. J., and Szego, C. M., 1979a, Estrogen receptors in uterine plasma membrane, J. Steroid Biochem. 11: 1471–1483.
Pietras, R. J., and Szego, C. M., 19796, Metabolic and proliferative responses to estrogen by hepatocytes selected for plasma membrane binding-sites specific for estradiol-1713, J. Cell. Physiol. 98: 145–160.
Pietras, R. J., and Szego, C. M., 1979c, Estrogen-induced membrane alterations and growth associated with proteinase activity in endometrial cells, J. Cell Biol. 81: 649–663.
Pike, J. W., Parker, J. B.. Haussier, M. R., Boass, A., and Toverud, S. V., 1979, Dynamic changes in circulating 1,25-dihydroxyvitamin D during reproduction in rats, Science 204: 1427–1429.
Pike, J. W., Dokoh, S., Haussier, M. R., Liberman, U. A., Marx, S. J., and Eil, C., 1984, Vitamin-D3-resistant fibroblasts have immunoassayable 1,25-dihydroxyvitamin D3 receptors, Science 224: 879–881.
Pinsky, L., 1978, The nosology of male pseudohermaphroditism due to androgen insensitivity, in: Sex Differentiation and Chromosomal Abnormalities. Birth Defects, Original Article Series, Vol. XIV (6C) ( R. L. Summitt and D. Bergsma, eds.), pp. 73–95, Alan R. Liss, New York.
Pinsky, L., and DiGeorge, A. M., 1965, Cleft palate in the mouse: A teratogenic index of glucocorticoid potency, Science 147: 402–403.
Pinsky, L., and Weksberg, R., 1969, Testosterone refractoriness of cultured human skin fibroblasts, Clin. Res. 17: 597A (Abstract).
Pinsky, L., Finkelberg, R., Straisfeld, C., Zilahi, B., Kaufman, M., and Hall, G., 1972, Testosterone metabolism by serially cultured fibroblasts from genital and nongenital skin of individual human donors, Biochem. Biophys. Res. Commun. 46: 364–369.
Pinsky, L., Kaufman, M., Straisfeld, C., and Shanfield, B., 1974, Lack of difference in testosterone metabolism between cultured skin fibroblasts of human adult males and females, J. Clin. Endocrinol. Metab. 39: 395–398.
Pinsky, L., Kaufman, M., Straisfeld, C., Zilahi, B., and Hall, C. St.-G.. 1978, Reductase activity of genital and nongenital skin fibroblasts from patients with 5a-reductase deficiency, androgen insensitivity, or unknown forms of male pseudohermaphroditism, Am. J. Med. Genet. 1: 407–416.
Pinsky, L., Kaufman, M., and Summitt, R. L., 1981, Congenital androgen insensitivity due to a qualitatively abnormal androgen receptor, Am. J. Med. Genet. 10: 91–99.
Pinsky, L., Kaufman, M., Gil-Esteban, C., and Sumbulian, D., 1983, Regulation of the androgen receptor in human genital skin fibroblasts, with a review of sex steroid receptor by homologous and heterologous steroids, Can. J. Biochem. Cell Biol. 71: 770–778.
Pinsky, L., Kaufman, M., Killinger, D. W., Burko, B., Shatz, D., and Volpé, R., 1984, Human minimal androgen insensitivity with normal dihydrotestosterone binding capacity in cultured genital skin fibroblasts: Evidence for an androgen-selective qualitative abnormality of the receptor, Am. J. Hum. Genet. 36: 965–978.
Pinsky, L., Kaufman, M., and Leboeuf, G., 1985a, A new type of ligand-independent partial androgen resistance detected with the aid of the synthetic androgen, 17a-methyl mibolerone (MB), Pediatr. Res. 19: 191A (Abstract 481).
Pinsky, L., Kaufman, M., and Chudley, A. E., 1985b, Reduced affinity of the androgen receptor for 5a-dihydrotestosterone but not methyltrienolone in a form of partial androgen resistance. Studies on cultured genital skin fibroblasts, J. Clin. Invest. 75: 1291–1296.
Plesko, M. M., Hargrove, J. L., Granner, D. K.. and Chalkley. R., 1983, Inhibition by sodium butyrate of enzyme induction by glucocorticoid and dibutryl cyclic AMP, J. Biol. Chem. 258: 13738–13744.
Pomerantz, S. M., Fox, T. H., Sholl, S. A., Vito. C. C., and Goy, R. W., 1985, Androgen and estrogen receptors in fetal rhesus monkey brain and anterior pituitary, Endocrinology 117: 83–89.
Porter, K. R., Puck, T. T., Hsie, A. W., and Kelley, D., 1974, An electron microscope study of the effects of dibutyryl cyclic AMP on Chinese hamster ovary cells, Cell 2: 145–162.
Post, M., and Smith, B. T., 1984, Effect of fibroblast-pneumoocyte factor on the synthesis of surfactant phospholipids in type II cells from fetal rat lung. Biochim. Biophys. Acta 793: 297–299.
Postel-Vinay, M. C., Alberti, C. M., Ricour, C., Limal, J. M., Rappaport, R., and Royer, P., 1974, Pseudohypoaldosteronism: Persistence of hyperaldosteronism and evidence for renal tubular and intestinal responsiveness to endogenous aldosterone, J. Clin. Endocrinol. Metab. 39: 1038–1044.
Powell, B. R., Buist, N. R. M., and Stenzel, P., 1982, An X-linked syndrome of diarrhea, polyendocrinopathy, and fatal infection in infancy, J. Pediatr. 100: 731–737.
Pratt, R. M., Kim, C. S., and Grove, R. I., 1984, Role of glucocorticoids and epidermal growth factor in normal and abnormal palatal development, Curr. Top. Dev. Biol. 19: 81–101.
Price, P., Wass, J. A. H., Griffin, J. E., Leshin, M., Savage, M. O., Largo, D. M., Bu’Lock, D. E., Anderson, D. C., Wilson, J. D., and Besser, G. M., 1984, High dose androgen therapy in male pseudohermaphroditism due to 5a-reductase deficiency and disorders of the androgen receptor, J. Clin. Invest. 74: 1496–1508.
Provvedini, F., Tsoukas, C., Deftos, L., and Manolagas, S. C., 1983, V
dihydroxyvitamin D3 receptor in human leukocytes, Science 221:1181–1182.
Puca, G. A., Nola, E., Sica, V., and Bresciani, F., 1977, Estrogen-binding proteins of calf uterus. Molecular and functional characterization of the receptor transforming factor: A Cat+activated protease, J. Biol. Chem. 252: 1358–1366.
Puck, T. T., Waldren, C. A., and Hsie, A. W., 1972, Membrane dynamics in the action of dibutyryl adenosine 3’:5’-cyclic monophosphate and testosterone on mammalian cells, Proc. Natl. Acad. Sci. USA 60: 1943–1947.
Pugeat, M. M., Chrousos, G. P., Nisula, B. C., Loriaux, D. L., Brandon, D., and Lipsett, M. B., 1984a, Plasma cortisol transport and primate evolution. Endocrinology 115: 357–361.
Pugeat, M., Rocle, B., Chrousos, G. P., Dunn, J. F., Lipsett. M. B., and Nisula, B. C., 19846, Plasma testosterone transport in primates, J. Steroid Biochem. 20: 473–478.
Puri, R. K., Grandics, P. Dougherty, J. J., and Toft, D. O., 1982. Purification of “non-transformed” avian progesterone receptor and preliminary characterization, J. Biol. Chem. 257: 10831–10837.
Rajfer, J., and Walsh, P. C., 1976, The incidence of intersexuality in patients with hypospadias and cryptorchidism, J. Urol. 116: 769–770.
Rayson, B. M., and Lowther, S. C., 1984, Steroid regulation of Na-K+ATPase: Differential sensitivities along the nephron, Am. J. Physiol. 246: F656 - F662.
Rees, A. M., and Bell, P. A., 1975, The involvement of receptor sulfhydryl groups in the binding of steroids to the cytoplasmic glucocorticoid receptor from rat thymus, Biochim. Biophys. Acta 411: 121–132.
Reichman, M. E., Foster, C. M., Eisen, L. P., Eisen, H. J., Torain. B. F., and Simon, S. S., Jr., 1984, Limited proteolysis of covalently labeled glucocorticoid receptors as a probe of receptor structure, Biochemistry 23: 5376–5384.
Reingold, S., and Rosenfield, R. L., 1984, Hirsutism and acne are variable manifestations of androgen excess, Clin. Res. 32: 809A (Abstract).
Reitsma, P. H., Rothberg, P. G., Astrin, S. M., Trial, J., Bar-Shavit, Z., Hall, A., Teitelbaum, S. L., and Kahn, A. J., 1983, Regulation of myc gene expression in HL-60 leukaemia cells by a vitamin D metabolite, Nature 306: 492–494.
Renkawitz, R., Schutz, G., von derAhe, D., and Beato, M., 1984, Sequences in the promoter region of the chicken lysozyme gene required for steroid regulation and steroid binding, Cell 37: 503–510.
Rennie, P. S., Bruchovsky, N., and Cheng, H., 1983, Isolation of 3S androgen-receptors from salt-resistant fractions and nuclear matrices of prostatic nuclei after mild trypsin digestion, J. Biol. Chem. 258: 7623–7630.
Renoir, J.-M., Buchou, T., Mester, J., Radanyi, C., and Baulieu, E. E., 1984, Oligomeric structure of molybdate-stabilized, nontransformed 8S progesterone receptor from chicken oviduct cytosol, Biochemistry 23: 6016–6023.
Resko, J. A., and Ellinwood, W. E., 1984, Sexual differentiation of the brain of primates, in: Sexual Differentiation: Basic and Clinical Aspects, ( M. Serio, M. Metta, M. Zanisi, and L. Martini ) (eds), Raven Press, New York, pp. 169–180.
Resnick, S. M., Berenbaum, S. A., Gottesman, I. I., and Bouchard, T. J., Jr., 1986, Early hormonal influences on cognitive functioning in congenital adrenal hyperplasia, Dev. Psycho!. 22: 191–198.
Richards, G., and Ashburner, M., 1984, Insect hormones and the regulation of genetic activity, in: Biological Regulation and Development, Volume 3B ( R. F. Goldberger, and K. R. Yamamoto, eds.), pp. 213–254, Plenum Press, New York.
Ring, D., and Hodgins, M. B., 1984, The regulation of androgen—receptor turnover in human genital skin fibroblasts by 5a-dihydrotestosterone, Biochem. Soc. Trans. 12: 658–659.
Ringold, G. M., 1985, Steroid hormone regulation of gene expression, Annu. Rev. Pharmacol. Toxicol. 25: 529–566.
Risbridger, G. P., Khalid, B. A. K., Warne, G. L., and Funder, J. W., 1982, Difference in proteins synthesized by fibroblasts from normal individuals and patients with complete testicular feminization, J. Clin. Invest. 69: 99–103.
Robins, D. M., Paek, I., Seebury, P. H., and Axel, R., 1982, Regulated expression of human growth hormone genes in mouse cells, Cell 29: 623–631.
Robinson, S. I., Nelkin, B. D., and Vogelstein, B., 1982, The ovalbumin gene is associated with the nuclear matrix of chicken oviduct cells, Cell 28: 99–106.
Rochefort, H., and Borgna, J.-L., 1981, Differences between oestrogen receptor activation by oestrogen and antioestrogen, Nature 292: 257–259.
Rodrigues Pereira, R., Brinkmann, A. O., and Hodgins, M. B., 1984, Partial androgen insensitivity as a cause of genital maldevelopment, Helv. Paediatr. Acta 39: 255–259.
Root, A. W., and Harrison, H. E., 1976, Recent advances in calcium metabolism I and II, J. Pediatr. 88: 177–199.
Rosen, J. F., Fleischman, A. R., Finberg, L., Hamstra, A., and DeLuca, H. F., 1979, Rickets with alopecia: An inborn error of vitamin D metabolism, J. Pediatr. 94: 729–735.
Rossini, G. P., and Liao, S., 1982, Intracellular inactivation, reactivation, and dynamic status of prostate androgen receptors, Biochem. J. 208: 383–392.
Roubinian, J. R., Talal, N., Greenspan, J. S., Goodman, J. R., and Siiteri, P. K., 1978, Effect of castration and sex hormone treatment on survival, antinucleic acid antibodies and glomerulonephritis in NZB/NZW F1 mice, J. Exp. Med. 147: 1568–1583.
Rousseau, G. G., and van Bohemen, C. G., 1984, Effects of membrane-active compounds on dexamethasone binding to the glucocorticoid receptor in intact cells, J. Steroid Biochem. 20: 37–41.
Rousseau, G. G., van Bohemen, C. G., Lareau, S., and Degelaem, J., 1982, Submicromolar free calcium modulates dexamethasone binding to the glucocorticoid receptor. Biochem. Biophys. Res. Commun. 106: 16–22.
Rousseau, G. G., Hue, L., Gannell, J., and Funder, J. W., 1984, Calcium and steroid receptors, 7th International Congress of Endocrinology, Excerpta Medica, Amsterdam, p. 155 (Abstract #S141).
Rowe, D., Starman, B. J., Fujimoto, W. Y., and Williams, R. H., 1977, Differences in growth response to hydrocortisone and ascorbic acid by human diploid fibroblasts, In Vitro 13: 824–830.
Rowley, D. R., Premont, R. T., Johnson, M. P., Young, C. Y. F., and Tindall, D. J., 1986, Properties of an intermediate-sized androgen receptor: Association with RNA, Biochemistry (in press).
Roy, A. K., Chatterjee, B., Demyan, W. F., Milin, B. S., Motwani, N. M., Nath, T. S., and Schiop, M. T., 1983, Hormone and age-dependent regulation of a2 globulin gene expression, Rec. Prog. Horm. Res. 39: 425–461.
Ruh, T. S., Ross, P., Jr., Wood, D. M., and Keene, J. L., 1981, The binding of [3H]oestradiolreceptor complexes to calf uterine chromatin, Biochem. J. 200: 133–142.
Ruh, M. F., Singh, R. K., Ruh, T. S., and Shyamala, G., 1986, Interaction of mammary glucocorticoid receptors from nulliparous and lactating mice with chromatin, Program of the 68th Annual Meeting of the Endocrine Society, June, p. 299 (Abstract #1074).
Russell, J. D., Russell, S. B., and Tropin, K. M., 1978, Differential effects of hydrocortisone on both growth and collagen metabolism of human fibroblasts from normal and keloid tissue, J. Tiss. Physiol. 97: 221–230.
Sadler, S. E., and Mailer, J. L., 1984, Plasma membrane steroid hormone receptors, in: The Receptors, Vol. I ( P. M. Conn, ed.), pp. 431–463, Academic Press, New York.
Saenger, P., 1984, Abnormal sexual differentiation, J. Pediatr. 104: 1–17.
Saenger, P., Goldman, A. S., Levine, L. S., Korthschutz, S., Muecke, E. C., Katsumata, M., Doberne, Y., and New, M. I., 1978, Prepubertal diagnosis of steroid 5a-reductase deficiency, J. Clin. Endocrinol. Metab. 46: 627–634.
Sakai, D., and Gorski, J., 1984, Estrogen receptor transformation to a high-affinity state without subunit–subunit interactions, Biochemistry 23: 3541–3547.
Sakly, M., and Koch, B., 1982, Physicochemical analysis of glucocorticoid receptor in the immature pituitary gland: Evidence for lability and aggregation of the heat-activated form, Mol. Cell. Endocrinol. 28: 27–35.
Salomon, D. S., and Pratt, R. M., 1978, Inhibition of growth in vitro by glucocorticoids in mouse embryonic facial mesenchyme cells, J. Cell. Physiol. 97: 315–328.
Salomon, D. S., and Pratt, R. M., 1979, Involvement of glucocorticoids in the development of the secondary palate: A review, Differentiation 13: 141–154.
Samuels, H. H., Casanova, J., Copp, R. P., Flug, F., Janocko, L., and Plotnick, M., 1986, DNA sequences which mediate thyroid hormone action, Program of the 68th Annual Meeting of the Endocrine Society, June, p. 11 (Abstract).
Sanborn, B. M., Steinberger, A., Tcholakian, R. K., and Steinberger, E., 1977, Direct measurement of androgen receptors in cultured Sertoli cells, Steroids 29: 493–502.
Sanchez, E. R., Toft, D. O., Schlesinger, M. J., and Pratt, W. B., 1985, Evidence that the 90-kDa phosphoprotein associated with the untransformed L-cell glucocorticoid receptor is a murine heat shock protein, J. Biol. Chem. 260: 12398–12401.
Sanders, M. M., and McKnight, G. S., 1985, Chicken egg white genes: Multihormonal regulation in a primary cell culture system, Endocrinology 116: 398–405.
Sando, J. J., LaForest, A. C., and Pratt, W. B., 1979, ATP-dependent activation of L-cell glucocorticoid receptors to the steroid-binding form, J. Biol. Chem. 254: 4772–4778.
Sandor, T., and Mehdi, A. Z., 1979, Steroids and evolution, in: Hormones and Evolution ( E. J. W. Barrington, ed.), pp. 1–72, Academic Press, New York.
Sandor, T., DiBattista, J. A., and Mehdi, A. Z., 1984, Glucocorticoid receptors in the gill tissue of fish, Gen. Comp. Endocrinol. 53: 353–364.
Sansone, G., and Reisner, R. M., 1971, Differential rates of conversion of testosterone to dihydrotestosterone in acne and in normal human skin—A possible pathogenic factor in acne, J. Invest. Dermatol. 56: 366–372.
Sar, M., Stumpf, W. E., McLean, W. S., Smith, A. A., Hansson, V., Nayfeh, S. N., and French, F. S., 1975, Localization of androgen target cells in the rat testis. Autoradiographic studies, in: Hormonal Regulation of Spermatogenesis ( F. S. French, V. Hans-son, E. M. Ritzen, and S. N. Nayfeh, eds.), p. 311–319, Plenum Press, New York.
Sarkar, P. K., and Lydigsen, J. L., 1978, Hydrocortisone receptors of hormone-responsive and irresponsive embryonic chick retina, Mol. Cell. Endocrinol. 10: 29–38.
Sasaki, S., and Kurisu, K., 1983, Effect of triamcinolone acetonide on proliferation and collagen and glycosaminoglycan synthesis in palatal mesenchymal cells from the mouse fetus, J. Craniofacial Genet. Dey. Biol. 3: 351–369.
Sasson, S., and Mayer, M., 1981, Effect of androgenic steroids in rat thymus and thymocytes in suspensions, J. Steroid Biochem. 14: 509–517.
Satayaviboon, S., Dawgert, F., Monteleone, P. L., and Monteleone, J. A., 1982. Persistent pseudohypoaldosteronism in a 7-year-old boy. Pediatrics 69: 458–462.
Sato, B., Noma, K., Nichizawa, Y., Nakao, K., Matsumoto, K., and Yamamura, Y., 1980, Mechanism of activation of steroid receptors: Involvement of low molecular weight inhibitor in activation of androgen, glucocorticoid and estrogen receptor systems, Endocrinology 106: 1142–1148.
Savage, M. O., Preece, M. A., Jeffcoate, S. L., Ransley, P. G., Rumsby, G., Mansfield, M. D., and Williams, D. I., 1980, Familial male pseudohermaphroditism due to deficiency of 5a-reductase, Clin. Endocrinol. 12: 397–406.
Savage, M. O., Jefferson, I. G., Dillon, M. J., Mitla, P. J., Honour, J.W., and Grant, D. B., 1982, Pseudohypoaldosteronism: Severe salt wasting in infancy caused by generalized mineralocorticoid unresponsiveness, J. Pediatr. 101: 239–242.
Scatchard, G., 1949, The attractions of proteins for small molecules and ions, Ann. N. Y. Acad. Sci. 51: 660–672.
Scheidereit, C., and Beato, M., 1984, Contacts between hormone receptor and DNA double helix within a glucocorticoid regulatory element of mouse mammary tumour virus, Proc. Natl. Acad. Sci. USA 81: 3029–3033.
Scheidereit, C., Geisse, S., Westphal, H. M., and Beato, M., 1983. The glucocorticoid receptor binds to defined nucleotide sequences near the promoter of mouse mammary tumour virus, Nature 304: 749–752.
Schmidt, T. J., Harmon, J. M., and Thompson, E. B., 1980, “Activation-labile” glucocorticoid–receptor complexes of a steroid-resistant variant of CEM-C7 human lymphoid cells, Nature 286:507–509.
Schmit, J.-P., Quivy, J. I., and Rousseau, G., 1980, The androgen receptor binding site: A conformational study of steroids in relation with their affinity—I. interaction with the D-ring, J. Steroid Biochem. 13: 1387–1394.
Schmidt, T. J., Diehl, E. E., Davidson, C. J., and Puk, M. J., 1986, Effects of bovine pancreatic ribonuclease A and S-protein on activation of purified rat hepatic glucocorticoid-receptor complexes. Program of the 68th Annual Meeting of the Endocrine Society, June, p. 298 (Abstract #1069).
Schneider, G., and Bardin, C. W., 1970, Defective testicular testosterone synthesis by the pseudohermaphrodite rat: An abnormality of 173-hydroxysteroid dehydrogenase, Endocrinology 87: 864–873.
Schoenberg, D. R., Martin, M. B., and Riegel, A. T., 1986, Posttranscriptional regulation of albumin gene expression by estrogen in Xenopus liver, Int. Council Sci. Unions Short Reports 4: 324–325.
Schrader, W. T., Birnbaumer, M. E., Hughes, M. R., Weigel, N. L., Grody, W. W., and O’Malley, B. W., 1981, Studies on the structure and function of the chicken progesterone receptor, Rec. Prog. Horm. Res. 37: 583–633.
Schulster, A., Ross, L., and Scommegna, A., 1983, Frequency of androgen insensitivity in infertile phenotypically normal men, J. Urol. 130: 699–701.
Schweikert, H. U., Milewich, L., and Wilson, J. D., 1975, Aromatization of androstenedione by isolated human hairs, J. Clin. Endocrinol. Metab. 40: 413–417.
Schweikert, H. U., Milewich, L., and Wilson, J. D., 1976, Aromatization of androstenedione by cultured human fibroblasts, J. Clin. Endocrinol. Metab. 43: 785–795.
Scully, R. E., Mark, E. J., and McNeely, B. U., 1982, Case records of the Massachusetts General Hospital, Case 25–1982, N. Engl. J. Med. 306: 1537–1544.
Seeley, D. H., and Costas, P. D., 1983, Transformation of a rabbit progesterone receptor from a 8S form to 5.55 and 4S forms, Mol. Cell. Endocrinol. 30: 161–178.
Seigler, L., and Svec, F., 1984, Characterization of the AtT-20 cells “repleting” glucocorticoid receptor, Biochim. Biophys. Acta 800: 111–118.
Sekeris, C. E., 1964, Action of ecdysone on RNA and protein metabolism in the blowfly, Caliphora erythrocephola, in: Mechanisms of Hormone Action ( P. Karlson, ed.), pp. 149–167, Academic Press, New York.
Sekula, B. C., Schmidt, T. J., and Litwack, G., 1981, Redefinition of modulator as an inhibitor of glucocorticoid receptor activation, J. Steroid Biochem. 14: 161–166.
Shah, R. K., 1984, Morphological, cellular and biochemical aspects of differentiation of normal and teratogen-treated palate in hamster and chick embryos, Curr. Top. Dev. Biol. 19: 103–135.
Shanies, D. D., Hirschhorn, K., and New, M. I., 1972, Metabolism of testosterone-’4C by cultured human cells, J. Clin. Invest. 51: 1459–1468.
Shapiro, B. H., 1985, A paradox in development: Masculinization of the brain without androgen receptors, in: Developmental Mechanisms: Normal and Abnormal ( J. W. Lash and L. Saxen, eds.), pp. 151–173, Alan R. Liss, New York.
Shapiro, B. H., and Goldman, A. S., 1973, Feminine saccharin preference in the genetically androgen insensitive male rat pseudohermaphrodite, Horm. Behay. 4: 371–375.
Shapiro, B. H., Levine, D. C., and Adler, N. T., 1980, The testicular feminized rat: A naturally occurring model of androgen-independent brain masculinization, Science 209: 418–420.
Shapiro, E., and Lippman, M. E., 1985, Onset of androgen action in MCF-7 human breast cancer cells is not accompanied by receptor depletion, J. Steroid Biochem. 22: 15–20.
Sheets, C. S., Aten, R. F., Kates, R. S., Preston, P. E., and Eisenfeld, A. J., 1985, Androgen receptor in the rabbit liver and apparent translocation to the nucleus in vivo, Endocrinology 116: 677–685.
Sher, E., Frampton, R. J., and Eisman, J. A., 1985, Regulation of 1,25-dihydroxyvitamin D3 receptor by 1,25-dihydroxyvitamin D3 in intact human cancer cells, Endocrinology 116: 971–977.
Sherman, M. R., and Stevens, J., 1984, Structure of mammalian steroid receptors: Evolving concepts and methodological developments, Anna. Rev. Physiol. 46: 83–105.
Sherman, M. R., Moran, M. C., Touzon, F. B., and Stevens, Y.-W., 1983, Structure, dissociation and proteolysis of mammalian steroid receptors: Multiplicity of glucocorticoid receptor forms and proteolytic enzymes in rat liver and kidney cytosols, J. Biol. Chem. 258: 10366–10377.
Shinki, T., Shiina, Y., Takahashi, H., Tanioka, Y., Koizumi, H., and Suda, T., 1983, Extremely high circulating levels of la-25-dihydroxyvitamin D3 in the marmoset, a New World monkey, Biochem. Biophys. Res. Commun. 114: 452–457.
Shinomiya, T., Scherer, G., Schmid, W., Zentgraf. H., and Schutz, G., 1984, Isolation and characterization of the rat tyrosine aminotransferase gene, Proc. Natl. Acad. Sci. USA 81: 1346–1350.
Shyamala, G., Singh, R. K., Ruh, M. F., and Ruh, T. S., 1986, Relationships between mammary estrogen receptor and estrogenic sensitivity. II. Binding of cytoplasmic receptor to chromatin. Endocrinology 119: 819–826.
Shyr, C., and Liao, S., 1978, A protein factor that inhibits binding and promotes the release of the androgen—receptor complex from nuclear chromatin, Proc. Natl. Acad. Sci. USA 75: 5969–5973.
Siiteri, P. K., 1985, Androgen action in the squirrel monkey, in: Regulation of Androgen Action ( N. Burchovsky, A. Chapdelaine, and F. Neumann, eds.), pp. 93–96, Congressdruck R. Bruckner, Berlin.
Siiteri, P. K., and Wilson, J. D., 1974, Testosterone formation and metabolism during male sexual differentiation in the human embryo, J. Clin. Endocrinol. Metab. 38: 113–125.
Simpson, J. L., 1982, Abnormal sexual differentiation in humans. Annu. Rev. Genet. 16: 193–224.
Simpson, R. V., and DeLuca, H. F., 1980, Characterization of a receptor-like protein for 1,25-dihydroxyvitamin D3 in rat skin, Proc. Natl. Acad. Sci. USA 77: 5822–5826.
Smallridge, R. C., Vigersky, R., Glass, A. R., Griffin, J. E., White, B. J., and Eil, C., 1984, Androgen receptor abnormalities in identical twins with oligospermia, Am. J. Med. Genet. 77: 1049–1054.
Smith, B. T.. 1978, Fibroblast-pneumonocyte factor: Intercellular mediator of glucocorticoid effect on fetal lung, in: Neonatal Intensive Care, Vol. II ( L. Stern, ed.), pp. 25–32, Masson, New York.
Smith, D. E., and Kronenberg, M. S., 1984, Effects of copper on cytoplasmic and nuclear binding of 17(3-estradiol in the rat uterus, Biol. Reprod. 31: 531–535.
Smith, R. G., Syms, A. J., and Morris, J. S., 1984, Differential effects of androgens and glucocorticoids on regulation of androgen receptor concentration and cell growth, J. Steroid Biochem. 20: 277–281.
Smith, D. W., Marokus, R., and Graham, J. M., Jr., 1985, Tentative evidence of Y-linked statural gene(s), Clin. Pediatr. 24: 189–192.
Snochowski, M., Dahlberg, E., and Gustafsson, J. A., 1980, Characterization and quantification of the androgen and glucocorticoid receptors in cytosol from rat skeletal muscle, Eur. J. Biochem. 111: 603–613.
Solomon, L. M., and Fretzin, D., 1970, Pilosebaceous abnormalities in Apert’s syndrome, Arch. Dermatol. 102: 381–385.
Somasekhar, M. B., and Gorski, J., 1986, DNA sequences required for EGF and glucocorticoid regulation and tissue specific expression of the rat prolactin gene, Program of the 68th Annual Meeting of the Endocrine Society, June, p. 139 (Abstract #433).
Southern, A. L., Rappaport, S. C., Gordon, G. C., and Vittek. J., 1978, Specific 5a-dihydrotestosterone receptors in human gingiva, J. Clin. Endocrinol. Metab. 47: 1378–1382.
Southwest Pediatric Nephrology Study Group, Dallas, Texas, 1985, Hepatitis B surface antigenemia in North American children with membranous glomerulonephropathy, J. Pediatr. 106: 571–578.
Spelsberg, T. C., Littlefield, B. A., Seelke, R., Dani, G. M., Toyoda, H., Boyd-Leinin, P., Thrall, C., and Kon, O. L., 1983, Role of specific chromosomal protein and DNA sequences in the nuclear binding sites for steroid receptors, Rec. Prog. Horm. Res. 39: 463–517.
Starkman, M. A., Schteingart, D. E., and Schork, M. A., 1981, Depressed mood and other psychiatric manifestations of Cushing’s syndrome: Relationship to hormone levels, Psychosom. Med. 43: 3–18.
Stevens, J., Eisen, H. J., Stevens, Y.-W., Haubenstock, H., Rosenthal, R. L., and Artishevsky, A., 1981, Immunochemical differences between glucocorticoid receptors from corticoid-sensitive and -resistant malignant lymphocytes, Cancer Res. 41: 134–137.
Stevens, J., Stevens, Y.-W., and Haubenstock, H., 1983, Molecular basis of glucocorticoid resistance in experimental and human leukemia, in: Biochemical Action of Hormones, Vol. 10 ( G. Litwacj, ed.), pp. 383–446, Academic Press. Nev, York.
Stewart, J., 1975, Genetic studies on the mechanism of action of aldosterone in mice, Endocrinology 96: 711–717.
Strean, I. P., and Peer, I. A., 1956, Stress as an etiologic factor in the development of cleft palate. Plast. Reconstruct. Surg. 18: 1–8.
Stumpf, W. E., Narbaitz, R., and Sar, M., 1980, Estrogen receptors in the fetal mouse, J. Steroid Biochem. 12: 55–64.
Suba, E. J., Estes, P. A., Wei, L. L., Horwitz, K. B., and Edwards. D. P., 1986, Immunoaffinity purification and structural analysis of the progesterone receptors from human breast cancer cells, Program of the 68th Annual Meeting of the Endocrine Society, June, p. 280 (Abstract #996).
Sultan, C., Migeon, B. R., Rothwell, S. W., Maes, M., Zerhouni. N., and Migeon, C. J., 1980, Androgen receptors and metabolism in cultured human fetal fibroblasts, Pediatr. Res. 13: 67–69.
Sultan, C., Picard, J.-Y., Josso, N., and Migeon, C. J., 1983. Incomplete androgen insensitivity syndrome: partially masculinized genitalia in two patients with absence of the androgen receptor in cultured fibroblasts, Clin. Endocrinol. 19: 565–574.
Svec, F., and Rudis, M., 1981, Glucocorticoids regulate the glucocorticoid receptor in the AtT-20 cell, J. Biol. Chem. 256: 5984–5987.
Svenson, J., and Snochowski, M., 1979, Androgen receptor levels in preputial skin from boys with hypospadias, J. Clin. Endocrinol. Metab. 49: 340–345.
Swaab, D. F., and Fliers, E., 1985, A sexually dimorphic nucleus in the human brain. Science 228: 1112–1115.
Swank, R. T., 1978, Role of growth hormone and testosterone in the synthesis of mouse kidney glucuronidase, Mol. Cell. Endocrinol. 12: 139–149.
Swank, R. T., Davey, R., Joyce, L., Reid, P., and Macey, M. R.. 1977. Differential effect of hypophysectomy on the synthesis of 3-glucuronidase and other androgen-inducible enzymes in mouse kidney, Endocrinology 100: 473–480.
Sweet, R. A., Schrott, H. G., Kurland, R., and Culp, O. S., 1974. Study of the incidence of hypospadias in Rochester, Minnesota, 1940–1970, and a case—control comparison of possible etiologic factors, Mayo Clin. Proc. 49: 52–58.
Syms, A. J., Norris, J. S., Panko, W. B., and Smith, R. B.. 1985, Mechanism of androgen-receptor augmentation. Analysis of receptor synthesis and degradation by the density-shift technique, J. Biol. Chem. 260: 455–461.
Szenberg, A., 1970, Influence of testosterone on the primary lymphoid organs of the chicken, in: Hormones of the Immune Response (G. E. Wolsteuholme and J. Knight, eds.), pp. 45–52, Ciba Foundation Group No. 36.
Takahashi, N., Suda, S., Shinki, T., Horiuchi, N.. Shiina, Y., Tanioka, Y., Koizumi, H., and Suda, T.. 1985. The mechanism of end-organ resistance to la-25-dihydroxycholecalciferol in the common marmoset. Biochem. J. 227: 555–563.
Tanuma, S., and Johnson, G. S., 1983, ADP-ribosylation of nonhistone high mobility group proteins in intact cells, J. Biol. Chem. 258: 4067–4070.
Tate, A. C., Greene, G. L., DeSombre, E. R., Jensen, E. V.. and Jordon, V. C., 1984, Differences between estrogen— and antiestrogen—estrogen receptor complexes from human breast tumors identified with an antibody raised against the estrogen receptor, Cancer Res. 44: 1012–1018.
Thiedemann, K.-U., and Drews, U., 1980, Nuclei in testicular feminization (Tfm) are not activated by intact testosterone receptor complexes: A morphometric study in striated urethral muscle of mosaic mice, Cell Tiss. Res. 212: 127–138.
Thomas, T., and Kiang, D. T., 1985, Effect of ribonuclease on the physico-chemical properties of estrogen receptor, J. Steroid Biochem. 23: 19–25.
Thompson, E. B., Norman, M. R., and Lippman, M. E., 1977a, Steroid hormone actions in tissue culture cells and cell hybrids—Their relation to human malignancies, Rec. Prog. Hom. Res. 33: 571–615.
Thompson, E. B., Aviv, D., and Lippman, M. E., 1977b, Variants of HTC cells with low tyrosine aminotransferinase inducibility and apparently normal glucocorticoid receptors, Endocrinology 100: 406–419.
Thompson, R. G., Nickel, B., Finlayson, S., Meuser, R., Hamerton, J. L., and Wrogemann, K., 1983, 56K fibroblast protein not specific for Duchenne muscular dystrophy but for skin biopsy site, Nature 304: 740–741.
Timberlake, W. E., and On, W. C., 1984, Steroid hormone regulation of sexual reproduction in Achlya, in: Biological Regulation and Development, Volume 3B, ( R. F. Goldberger, and K. R. Yamamoto, eds.), pp. 255–284, Plenum Press, New York.
Tindall, D. J., Chang, C. H., Lobl, T. J., and Cunningham, G. R., 1984, Androgen antagonists in androgen target tissues, Pharmacol. Ther. 24: 367–400.
Tobert, S. A., Shim, J. H., Osiecki, S. T., Baum, M. J., and Canick, J. A., 1985, Androgen aromatization and 5a-reduction in ferret brain during perinatal development: Effects of sex and testosterone manipulation, Endocrinology 116: 1869–1877.
Toft, D., and Nishigori, H., 1979, Stabilization of the avian progesterone receptor by inhibitors, J. Steroid Biochem. 11: 413–416.
Toole, J. J., Hastie, N. D., and Held, W. A., 1979, An abundant androgen-regulated mRNA in the mouse kidney, Cell 17: 441–448.
Toran-Allerand, C. D., 1984, On the genesis of sexual differentiation of the central nervous system: Morphogenetic consequences of steroidal exposure and possible role of afetoprotein, Prog. Brain Res. 61: 63–98.
Torday, J. S., 1984, The sex difference in type II cell surfactant synthesis originates in the fibroblast, Exp. Lung Res. 7: 187–194.
Torday, J. S., 1985, Dihydrotestosterone inhibits fibroblast-pneumonocyte factor-mediated synthesis of saturated phosphatidylcholine by fetal rat lung cells, Biochim. Biophys. Acta 835: 23–28.
Torday, J. S., Nielsen, H. C., French, M., and Avery, M. E., 1981, Sex differences in fetal lung maturation, Am. Rev. Respir. Dis. 123: 205–208.
Traish, A. M., Müller, R. E., and Wotiz, H. H., 1984, Differences in the physicochemical characteristics of androgen–receptor complexes formed in vivo and in vitro, Endocrinology 114: 1761–1769.
Tymoczko, J. L., and Lee, J. H., 1985, Chymotrypsin treatment of glucocorticoid receptor attenuates RNA-dependent inhibition of DNA binding. Evidence for a distinct RNA-binding site, Biochim. Biophys. Acta 846: 193–199.
Tymoczko, J. L., and Moses, J., 1986, Steroid-free glucocorticoid receptor is associated with RNA, Program of the 68th Annual Meeting of the Endocrine Society, June, p. 299 (Abstract #1072).
Tymoczko, J. L., and Phillips, M. M., 1983, The effects of ribonuclease on rat liver dexamethasone receptor: increased affinity for deoxyribonucleic acid and altered sedimentation profile. Endocrinology 112: 142–149.
Uhlin, S. R., and McCarty, K. S., Jr., 1983, Unilateral nevoid telangiectatic syndrome. The role of estrogen and progesterone receptors, Arch. Dermatol. 119: 226–228.
Vagenakis, A. G., Hamilton, C., Maloof, F., Braverman, L. E., and Ingbar, S. H., 1972, The concentration and binding of thyroxine in the serum of patients with the testicular feminization syndrome: Observations on the effects of ethinyl estradiol and norethandrolone, J. Clin. Endocrinol. Metab. 34: 327–331.
Van Bohemen, C. G., Eliard, P. H., and Rousseau, G. G., 1983, Control by calcium ions of steroid binding to the glucocorticoid receptor, Molec. Physiol. 4: 95–110.
Van der Schoot, P., 1980, Effects of dihydrotestosterone and oestradiol on sexual differentiation in male rats, J. Endocrinol. 84: 397–407.
Vanha-Perttula, T., Schneider, G., Bardin, C. W., Stanley, A. J., Gumbreck, L. G., and Allison, J. E., 1970, Testicular tumors in the androgen insensitive pseudohermaphrodite rat: Histochemistry and steroid metabolism, Gynecol. Invest. 1: 149–160.
Varmus, H. E., 1982, Form and function of retroviral proviruses, Science 216: 812–820.
Vedeckis, W. V., Kovacic-Milivojevic, B., and Chang, C.-H., 1986, Absence of RNA in the untranformed mouse glucocorticoid receptor, Program of the 68th Annual meeting of the Endocrine Society, June, p. 264 (Abstract #934).
Vekemans, M. J. J., and Biddle, F. G., 1984, Genetics of palate development, Curr. Top. Del. Biol. 19: 166–191.
Venetianer, A., and Bösze, Z., 1983, Expression of differentiated functions in dexamethasone-resistant hepatoma cells, Differentiation 25: 70–78.
Vingerhoeds, A. C. M., Thijssen, J. H. H., and Schwarz, F., 1976, Spontaneous hyper- cortisolism without Cushing’s syndrome, J. Clin. Endocrinol. Metab. 43: 1128–1133.
Waber, D. P., 1979, Cognitive abilities and sex-related variations in the maturation of cerebral cortical function for sex differences in cognition, in: Sex Related Differences in Cognitive Functioning ( M. A. Wittig and A. C. Peterson, eds.), p. 161–186 Academic Press, New York.
Walker, B., 1965, Cleft palate produced in mice by human-equivalent dosage with triamcinolone, Science 149: 862–863.
Walker, B. E., and Fraser, F. C., 1957, The embryology of cortisone-induced cleft palate, J. Embryo!. Exp. Morphol. 5: 201–209.
Walsh, P. C., Madden, J. D., Harrod, M. J., Goldstein, J. L., MacDonald, P.C., and Wilson, J. D., 1974, Familial incomplete male pseudohermaphroditism, type 2: Decreased dihydrotestosterone formation in pseudovaginal perineoscrotal hypospadias, N. Engl. J. Med. 291: 944–949.
Walters, M. R., Hunziker, W., and Norman, A. W., 1980, Unoccupied 1,25-dihydroxyvitamin D3 receptors, J. Biol. Chem. 255: 6799–6805.
Warne, G. L., Gyorki, S., Risbridger, G. P., Khalid, B. A. K., and Funder, J. W., 1983, Fibroblast studies on clinical androgen insensitivity, J. Steroid Biochem. 19: 583–586.
Watanabe, M., and Watanabe, H., 1974, Periplasmic steroid-binding proteins and steroid transforming enzymes of Pseudomonas testosteroni, J. Steroid Biochem. 5: 439–446.
Wei, L. L., Suba, E. J., Sheridan, P. L., Francis, M. D., Edwards, D. P., and Horwitz, K. B., 1986, Immunologic analysis of the nuclear modifications and processing of human breast cancer progesterone receptors. Program of the 68th Annual Meeting of the Endocrine Society, June, p. 138 (Abstract #428).
Weichman, B. M., and Notides, A. C., 1977, Estradiol-binding kinetics of the activated and nonactivated estrogen receptor, J. Biol. Chem. 252: 8856–8862.
Weinberger, C., Hollenberg, S. M., Rosenfeld, M. G., and Evans, R. M., 1985, Domain structure of human glucocorticoid receptors and its relationship to the v-erb-A oncogene product, Nature 318: 670–672.
Weintraub, H., and Groudine, M., 1976, Chromosomal subunits in active genes have an altered conformation, Science 193: 848–856.
Welch, W. R., and Robboy, S. J., 1981, Abnormal sexual development: A classification with emphasis on pathology and neoplastic conditions, in: Pediatric Andrology, Vol. 7 ( S. J. Kogan, and E. S. E. Hafez, eds.), pp. 71–85, Martinus Nijhoff, The Netherlands.
Welshons, W. V., Lieberman, M. E., and Gorski, J., 1984, Nuclear localization of unoccupied oestrogen receptors, Nature 307: 747–749.
Westphal, H. M., Moldenhauer, G., and Beato, M., 1982, Monoclonal antibodies to the rat liver glucocorticoid receptor, EMBO J. 1: 1467–1471.
Westphal, H. M., Mugele, K., Beato, M., and Gehring, U., 1984, Immunochemical characterization of wild-type and variant glucocorticoid receptors by monoclonal antibodies. EMBO J. 3: 1493–1498.
Wieland, S. J., and Fox, T. O., 1979, Putative androgen receptors distinguished in wild-type and testicular feminized (Tfm) mice, Cell 17: 781–787.
Wieland, S. J., and Fox, T. O., 1981, Androgen receptors from rat kidney and brain: DNA- binding properties of wild-type and tfm mutant, J. Steroid Biochem. 14: 409–414.
Wieland, S. J., Fox, T. O., and Savakis, C., 1978, DNA-binding of androgen and estrogen receptors from mouse brain: Behavior of residual androgen receptor from Tfm mutant, Brain Res. 140: 159–164.
Wilbert, D. M., Griffin, J. E., and Wilson, J. D., 1983, Characterization of the cytosol androgen receptor of the human prostate, J. Clin. Endocrinol. Metab. 56: 113–120.
Wilkin, R. P., Bruchovsky, N., Shnitka, T. K., Rennie, P. S., and Comeau, T. L., 1980, Stromal 5a-reductase activity is elevated in benign prostatic hyperplasia, Acta Endocrinol. 94: 284–288.
Wilkins, L., 1965, The Diagnosis and Treatment of Endocrine Disorders in Children and Adolescence, 3rd ed., Charles C Thomas, Springfield, Illinois.
Wilson, J. D., and Walker, J. D., 1969, The conversion of testosterone to 5a-androstan170-o1–3-one (dihydrotestosterone) by skin slices of man, J. Clin. Invest. 48:371–379.
Wilson, J. D., Harrod, M. J., Goldstein, J. L., Hemsell, D. L., and MacDonald, P. C., 1974, Familial incomplete male pseudohermaphroditism, type 1: Evidence for androgen resistance and variable clinical manifestations in a family with the Reifenstein syndrome, N. Engl. J. Med. 290: 1097–1103.
Wilson, J. D., Aiman, J., and MacDonald, P. C., 1980, The pathogenesis of gynecomastia, Adv. Intern. Med. 25: 1–25.
Wilson, J. D., Griffin, J. E., Leshin, M., and MacDonald, P. C., 1983, The androgen resistance syndrome: 5a-Reductase deficiency, testicular feminization, and related disorders, in: The Metabolic Basis of Inherited Disease ( J. B. Stanbury, J. B. Wyngaarden, D. S. Fredrickson, J. L. Goldstein, and M. S. Brown, eds.), pp. 1001–1026, McGraw-Hill, New York.
Wilson, M. I., Brown, G. M., and Wilson, D., 1978, Annual and diurnal changes in plasma androgen and cortisol in adult male squirrel monkeys (Saimiri sciureus) studied longitudinally, Acta Endocrinol. 87: 424–433.
Wrange, Ö., and Gustafsson, J.-A., 1978, Separation of the hormone-and DNA-binding sites of the hepatic glucocorticoid receptor by means of proteolysis, J. Biol. Chem. 253: 856–865.
Wrogemann, K., Rosenmann, E., Nickel, B., Schwartz, A., and Pinsky, L., 1986, A 56 kDa protein from human cultured skin fibroblasts appears structurally related to the androgen receptor, Program of the 29th Annual Meeting of the Canadian Federation of Biological Societies, June, (Abstract PA-67, p. 95 ).
Yamamoto, K. R., 1985, Steroid receptor regulated transcription of specific genes and gene networks, Ann. Rev. Genet. 19: 209–252.
Yang, C.-R., Mester, J., Wolfson, A., Renoir, J.-M., and Baulieu, E.-E., 1982, Activation of the chick oviduct progesterone receptor by heparin in the presence or absence of hormone, Biochem. J. 208: 399–406.
Yoneda, T., and Pratt, R. M., 1981, Glucocorticoid receptors in palatal mesenchymal cells from the human embryo: Relevance to human cleft palate formation, J. Craniofacial Genet. Dev. Biol. 1: 411–423.
Yoneda, T., and Pratt, R. M., 1982, Vitamin B6 reduces cortisone-induced cleft palate in the mouse, Teratology 26: 255–258.
Yoneda, T., Goldman, A. S., Van Dyke, D. C., Wilson, L. S., and Pratt, R. M., 1981, Decreased number of glucocorticoid receptors in dermal fibroblasts from individuals with facial clefting: A preliminary report, J. Craniofacial Dey. Biol. 1: 229–234.
Yuh, Y.-S., and Thompson, B., 1986, Somatic cell hybridization of two glucocorticoid resistant human leukemic cell lines demonstrates complementation between glucocorticoid receptor and lymphocytolysis, Program of the 68th Annual Meeting of the Endocrine Society, June, p. 251 (Abstract #881).
Yund, M. A., King, D. S., and Fristrom, J. W., 1978, Ecdysteroid receptors in imaginal discs of Drosophila melanogaster, Proc. Natl. Acad. Sci. USA 75: 6039–6043.
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Pinsky, L., Kaufman, M. (1987). Genetics of Steroid Receptors and Their Disorders. In: Harris, H., Hirschhorn, K. (eds) Advances in Human Genetics. Advances in Human Genetics, vol 16. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0620-8_5
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