Chronic Granulomatous Disease

  • John T. Curnutte
  • Bernard M. Babior
Part of the Advances in Human Genetics book series (AHUG, volume 16)


Chronic granulomatous disease (CGD) is a rare inherited disorder of host defense in which the phagocytic components of the immune system (neutrophils, eosinophils, monocytes, and macrophages) fail to generate hydrogen peroxide and oxygen radicals upon stimulation. Since these oxidants are normally used by phagocytes to kill microorganisms, phagocytes from patients with CGD show impaired microbicidal activity, and the patients themselves suffer from recurrent, and often life-threatening, bacterial and fungal infections.


NADPH Oxidase Human Neutrophil Respiratory Burst Chronic Granulomatous Disease Respiratory Burst Activity 
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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • John T. Curnutte
    • 1
  • Bernard M. Babior
    • 2
  1. 1.Department of PediatricsUniversity of Michigan School of MedicineAnn ArborUSA
  2. 2.Department of Basic and Clinical ResearchScripps Clinic and Research FoundationLa JollaUSA

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