An Overview
  • M. J. Brownstein
  • H. Gainer


In the four decades that have passed since Ernst and Berta Scharrer suggested that certain populations of central neurons secrete peptide hormones,1 a multitude of biologically active peptides have been discovered and/or characterized in brain extracts (Table I). Some of these were first found in the brain, others in nonnervous tissue such as gut, pancreas, skin, or pituitary. When a peptide is discovered in the CNS that is present in other organs, it must be characterized. The form of the peptide in brain may be different from the form in the periphery. Furthermore, it is unsafe to assume that all peptides found in brain are made there; they may be made in the periphery and transported to and concentrated in the brain.


Vasoactive Intestinal Polypeptide Brain Extract Opiate Receptor Hypothalamic Neuron Basic Amino Acid Residue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1982

Authors and Affiliations

  • M. J. Brownstein
    • 1
  • H. Gainer
    • 2
  1. 1.Laboratory of Clinical ScienceNational Institute of Mental HealthBethesdaUSA
  2. 2.Laboratory of Developmental NeurobiologyNational Institute of Child Health and Human DevelopmentBethesdaUSA

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