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Epidermodysplasia Verruciformis

  • Chapter
The Papovaviridae

Part of the book series: The Viruses ((VIRS))

Abstract

Epidermodysplasia verruciformis (EV) is a rare lifelong skin disease, which begins during infancy or childhood. It is induced by numerous specific types of human papillomaviruses (HPVs), sometimes including the HPVs associated with flat warts in the general population. EV is characterized by refractory, disseminated skin lesions resembling flat warts, or presenting as macules of various colors. Cutaneous carcinomas in situ or invasive carcinomas usually of Bowen’s type, appear in a high proportion of the patients, generally at an early age. HPV DNA sequences, usually HPV type 5, are regularly detected in EV carcinomas. EV is a multifactorial disease which involves genetic, immunological, and extrinsic factors, in addition to specific HPVs. This has been suggested by the parental consanguinity and the sibling involvement observed in some cases, the impaired cell-mediated immunity reported in most patients, and the usual localization of skin cancers in light-exposed areas. Reviews on EV have been published by Maschkilleisson (1931), Sullivan and Ellis (1939), Midana (1949), Jablonska and Milewski (1957), Bilancia (1961), Jablonska et al. (1966, 1972), Oehlschlaegel et al. (1966), Relias et al. (1967), Tsoitis et al. (1973), Rueda and Rodriguez (1976), Kaufmann et al. (1978), Lutzner (1978), Orth et al. (1980), Jablonska and Orth (1985), and Orth (1986).

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References

  • Aaronson, C. M., and Lutzner, M. A., 1967, Epidermodysplasia verruciformis and epidermoid carcinoma: Electron microscopic observations, J. Am. Med. Assoc. 201: 775–777.

    Article  CAS  Google Scholar 

  • Androphy, E. J., Dvoretzky, I., Maluish, A. E., Wallace, H. J., and Lowy, D. R., 1984, Response of warts in epidermodysplasia verruciformis to treatment with systemic and intralesional alpha interferon, J. Am. Acad. Dermatol. 11: 197–202.

    Article  PubMed  CAS  Google Scholar 

  • Androphy, E. J., Dvoretzky, I., and Lowy, D. R., 1985, X-linked inheritance of epidermodysplasia verruciformis: Genetic and virologic studies of a kindred, Arch. Dermatol. 121: 864–868.

    Article  PubMed  CAS  Google Scholar 

  • Baker, H., 1968, Epidermodysplasia verruciformis with electron microscopic demonstration of virus, Proc. R. Soc. Med. 61: 7–8.

    Google Scholar 

  • Beaudenon, S., Kremsdorf, D., Croissant, O., Jablonska, S., Wain-Hobson, S., and Orth, G., 1986, A new type of human papillomavirus associated with genital neoplasias, Nature 321: 246–249.

    Article  PubMed  CAS  Google Scholar 

  • Beaudenon, S., Praetorius, F., Kremsdorf, D., Lutzner, M., Worsaae, N., Pehau-Arnaudet, G., and Orth, G., 1987, A new type of human papillomavirus associated with oral focal epithelial hyperplasia, J. Invest. Dermatol. 88 (in press).

    Google Scholar 

  • Bilancia, A., 1961, Considerazioni su una sindrome dermatologica molto discussa: la epidermodisplasia verruciforme di Lewandowsky e Lutz, Arch. Ital. Dermatol. 32: 425–450.

    Google Scholar 

  • Blanchet-Bardon, C., and Lutzner, M. A., 1985, Interferon and retinoid treatment of warts, Clin. Dermatol. 3 (4): 195–199.

    Article  PubMed  CAS  Google Scholar 

  • Blanchet-Bardon, C., Puissant, A., Lutzner, M., Orth, G., Nutini, M. T., and Guesry, P., 1981, Interferon treatment of skin cancer in patients with epidermodysplasia verruciformis, Lancet 1: 274.

    Article  PubMed  CAS  Google Scholar 

  • Bloc, G., Faye, I., Basset, A., Privat, Y., Ruscher, H., Camain, R., and Sarrat, H., 1971, Epidermodysplasie verruciforme de Lewandowsky—Lutz chez des Noirs Africains, Bull. Soc. Med. Afr. Noire Lang. Fr. 16: 558–590.

    Google Scholar 

  • Boshart, M., Gissmann, L., Ikenberg, H., Kleinheinz, A., Scheurlen, W., and zur Hausen, H., 1984, A new type of papillomavirus DNA, its presence in genital cancer biopsies and in cell lines derived from cervical cancer, EMBO J. 3: 1151–1157.

    PubMed  CAS  Google Scholar 

  • Botstein, D., White, R. L., Skolnick, M., and Davis, R. W., 1980, Construction of a genetic linkage map using restriction fragment length polymorphisms, Am. J. Hum. Genet. 32: 314–331.

    PubMed  CAS  Google Scholar 

  • Boyle, J., Mackie, R. M., Briggs, J. D., Junor, B. J. R., and Aitchison, T. C., 1984, Cancer, warts, and sunshine in renal transplant patients: A case-control study, Lancet 1: 702–705.

    Article  PubMed  CAS  Google Scholar 

  • Brackmann, K. H., Green, M., Wold, W. S. M., Rankin, A., Loewenstein, P. M., Cartas, M. A., Sanders, P. R., Olson, K., Orth, G., Jablonska, S., Kremsdorf, D., and Favre, M., 1983, Introduction of cloned human papillomavirus genomes into mouse cells and expression at the RNA level, Virology 129: 12–24.

    Article  PubMed  CAS  Google Scholar 

  • Bundino, S., Zina, A M, and Bernengo, M. G., 1978, Dyskeratosis congenita with epidermodysplasia verruciformis of Lewandowsky and Lutz, Dermatologica 156: 15–23.

    Article  PubMed  CAS  Google Scholar 

  • Califano, A., and Caputo, R., 1968, La microscopia elettronica nello studio delle precancerosi epiteliali cutanee, Minerva Dermatol. 43: 567–616.

    Google Scholar 

  • Claudy, A. L., Touraine, J. L., and Mitanne, D., 1982, Epidermodysplasia verruciformis induced by a new human papillomavirus (HPV-8): Report of a case without immune dysfunction. Effect of treatment with an aromatic retinoid, Arch. Dermatol. Res. 274: 213–219.

    Article  PubMed  CAS  Google Scholar 

  • Coggin, J. R., Jr., and zur Hausen, H., 1979, Workshop on papillomaviruses and cancer, Cancer Res. 39: 545–546.

    Google Scholar 

  • Cornelius, C. E., Witkowski, J. A., and Wood, M. G., 1968, Viral verruca, human papovavirus infection: Epidermodysplasia verruciformis, vacuolar degeneration of the epidermis, Arch. Dermatol. 98: 377–384.

    Article  PubMed  Google Scholar 

  • Croissant, O., Testanière, V., and Orth, G., 1982, Mise en évidence et localisation de régions conservées dans les génomes du papillomavirus humain la et du papillomavirus bovin 1 par analyse de molécules “hétéroduplexes” au microscope électronique, C. R. Acad. Sci. 294: 581–586.

    CAS  Google Scholar 

  • Croissant, O., Breitburd, F., and Orth, G., 1985, Specificity of cytopathic effect of cutaneous human papillomaviruses, Clin. Dermatol. 3 (4): 43–55.

    Article  PubMed  CAS  Google Scholar 

  • Danos, O., 1986, Architecture et fonctionnement du génome des papillomavirus, Thèse de Doctorat, Université Paris 7.

    Google Scholar 

  • Danos, O., Giri, I., Thierry, F., and Yaniv, M., 1984, Papillomavirus genomes: Sequences and consequences, J. Invest. Dermatol. 83: 7s - 11s.

    Article  PubMed  CAS  Google Scholar 

  • Danos, O., Georges, E., Orth, G., and Yaniv, M., 1985, Fine structure of the cottontail rabbit papillomavirus mRNAs expressed in the transplantable VX2 carcinoma, J. Virol. 53: 735–741.

    PubMed  CAS  Google Scholar 

  • Delescluse, C., Pruniéras, M., Régnier, M., Arouete, J., and Grupper, C., 1970, Incorporation de thymidine tritiée dans les verrues vulgaires, les papillomes cornés, et l’épidermodysplasie verruciforme, Ann. Dermatol. Syphiligr. 97: 525–533.

    CAS  Google Scholar 

  • Delescluse, C., Pruniéras, M., Régnier, M., Moreno, G., and Arouete, J., 1972, Epidermodysplasia verruciformis. I. Electron microscope autoradiography and tissue culture studies, Arch. Dermatol. Forsch. 242: 202–215.

    PubMed  CAS  Google Scholar 

  • Delescluse, C., Régnier, M., and Pruniéras, M., 1973, Epidermodysplasia verruciformis. II. Uridine incorporation, Arch. Dermatol. Forsch. 247: 89–97.

    PubMed  CAS  Google Scholar 

  • Depaoli, M., 1971, Epidermodisplasia verruciforme con degenerazione bowenoide et epiteliomatosa multipla, baso e spinocellulare, Minerva Dermatol. 46: 407–417.

    CAS  Google Scholar 

  • Dunham, L. J., 1972, Cancer in man at site of prior benign lesion of skin or mucous membrane: A review, Cancer Res. 32: 1359–1374.

    PubMed  CAS  Google Scholar 

  • Durst, M., Gissmann, L., Ikenberg, H., and zur Hausen, H., 1983, A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions, Proc. Natl. Acad. Sci. USA 80: 3812–3815.

    Article  PubMed  CAS  Google Scholar 

  • Durst, M., Kleinheinz, A., Hotz, M., and Gissmann, L., 1985, The physical state of human papillomavirus type 16 DNA in benign and malignant genital tumors, J. Gen. Virol. 66: 1515–1522.

    Article  PubMed  Google Scholar 

  • Duveme, J., Pruniéras, M., Mazauric, F. X., and Vial, A. M., 1973, Epidermodysplasie verruciforme: étude clinique, histologique (microscopie électronique) et autoradiographique à propos d’un cas, Lyon Med. 229: 567–571.

    Google Scholar 

  • Duveme, J., Pruniéras, M., Mazauric, F. X., and Vial, A. M., 1976, Quelques réflexions à propos d’un cas d’épidermodysplasie verruciforme, Bull. Soc. Fr. Dermatol. Syphiligr. 83: 304–306.

    Google Scholar 

  • Fisher, M. S., and Kripke, M. L., 1982, Suppressor T lymphocytes control the development of primary skin cancers in ultraviolet irradiated mice, Science 216: 1133–1134.

    Article  PubMed  CAS  Google Scholar 

  • Fuchs, P. G., Iftner, T., Weninger, J., and Pfister, H., 1986, Epidermodysplasia verruciformisassociated human papilloma virus 8: Genomic sequence and comparative analysis, J. Virol. 58: 626–634.

    PubMed  CAS  Google Scholar 

  • Gassenmaier, A., Lammel, M., and Pfister, H., 1984, Molecular cloning and characterization of the DNAs of human papillomaviruses 19, 20, and 25 from a patient with epidermodysplasia verruciformis, J. Virol. 52: 1019–1023.

    PubMed  CAS  Google Scholar 

  • Gavanou, J., Gambert, I., Lambert, D., Laurent, R., Agache, P., and Chapuis, J. L., 1976, Aspects cliniques d’épidermodysplasie verruciforme avec déficit congénital en IgM, Bull. Soc. Fr. Dermatol. Syphiligr. 83: 298–304.

    Google Scholar 

  • Georges, E., Croissant, O., Bonneaud, N., and Orth, G., 1984, Physical state and transcription of the cottontail rabbit papillomavirus genome in warts and transplantable VX2 and VX7 carcinomas of domestic rabbits, J. Virol. 51: 530–538.

    PubMed  CAS  Google Scholar 

  • Gissmann, L., Pfister, H., and zur Hausen, H., 1977, Human papilloma viruses (HPV): Characterization of four different isolates, Virology 76: 569–580.

    Article  PubMed  CAS  Google Scholar 

  • Glinski, W., Jablonska, S., Langner, A., Obalek, S., Haftek, M., and Proniewska, M., 1976, Cell-mediated immunity in epidermodysplasia verruciformis, Dermatologica 153: 218–227.

    Article  PubMed  CAS  Google Scholar 

  • Glinski, W., Obalek, S., Jablonska, S., and Orth, G., 1981, T-cell defect in patients with epidermodysplasia verruciformis due to human papillomavirus types 3 and 5, Dermatologica 162: 141–147.

    Article  PubMed  CAS  Google Scholar 

  • Goldes, J. A., Filipovitch, A. H., Neudorf, S. M., Bender, M. E., Ostrow, R. S., Faras, A., and Goltz, R. W., 1984, Epidermodysplasia verruciformis in a setting of common variable immunodeficiency, Pediatr. Dermatol. 2: 136–139.

    Article  PubMed  CAS  Google Scholar 

  • Green, M., Orth, G., Wold, W. S. M., Sanders, P. R., McKay, J. K., Favre, M., and Croissant, O., 1981, Analysis of human cancers, normal tissues and verrucae plantares for DNA sequences of human papillomavirus types 1 and 2, Virology 110: 176–184.

    Article  PubMed  CAS  Google Scholar 

  • Green, M., Brackmann, K. H., Sanders, P. R., Loewenstein, P. M., Freel, J. H., Eisinger, M., and Switlyk, S. A., 1982, Isolation of a human papillomavirus from a patient with epidermodysplasia verruciformis: Presence of related viral DNA genomes in human urogenital tumors, Proc. Natl. Acad. Sci. USA 79: 4437–4441.

    Article  PubMed  CAS  Google Scholar 

  • Grupper, C., Pruniéras, M., Delescluse, C., Arouete, J., and Garelly, E., 1971, Epidermodysplasie verruciforme: Etudes ultrastructurale et autoradiographique, Ann. Dermatol. Syphiligr. 98: 33–48.

    CAS  Google Scholar 

  • Guilhou, J. J., Malbos, S., Barneon, S., Habib, A., Baldet, P., and Meynadier, J., 1980, Epidermodysplasie verruciforme (2 observations): Etude immunologique, Ann. Dermatol. Venereol. 107: 611–619.

    PubMed  CAS  Google Scholar 

  • Haftek, M., Jablonska, S., and Orth, G., 1985, Specific cell-mediated immunity in patients with epidermodysplasia verruciformis and plane warts, Dermatologica 170: 213–220.

    Article  PubMed  CAS  Google Scholar 

  • Hammar, H., Hammar, L., Lambert, B., and Ringborg, U., 1976, A case report including EM and DNA repair investigations in a dermatosis associated with multiple skin cancers: Epidermodysplasia verruciformis, Acta Med. Scand. 200: 441–446.

    Article  PubMed  CAS  Google Scholar 

  • Hardie, I. R., Strong, R. W., Hartley, L. C. J., Woodruff, P. W. H., and Clunie, G. J. A., 1980, Skin cancer in Caucasian renal allograft recipients living in a subtropical climate, Surgery 87: 177–183.

    PubMed  CAS  Google Scholar 

  • Heilman, C. A., Law, M. F., Israel, M. A., and Howley, P. M., 1980, Cloning of human papilloma virus genomic DNAs and analysis of homologous polynucleotide sequences, J. Virol. 36: 395–407.

    PubMed  CAS  Google Scholar 

  • Herberman, R. B. (ed.), 1983, Basic and Clinical Tumor Immunology, Nijhoff, The Hague.

    Google Scholar 

  • Hoffmann, E., 1926, Über verallgemeinerte Warzenerkrankung (Verrucosis generalisata) und ihre Beziehung zur Epidermodysplasia verruciformis (Lewandowsky), Dermatol. Z. 48: 241–266.

    Article  Google Scholar 

  • Hoxtell, E. O., Mandel, J. S., Murray, S. S., Schuman, L. M., and Goltz, R. W., 1977, Incidence of skin carcinoma after renal transplantation, Arch. Dermatol. 113: 436–438.

    Article  PubMed  CAS  Google Scholar 

  • Ikenberg, M., Gissmann, L., Gross, G., Grussendorf-Conen, E. I., and zur Hausen, H., 1983, Human papillomavirus type 16-related DNA in genital Bowen’s disease and in Bowenoid papulosis, Int. J. Cancer 32: 563–565.

    Article  PubMed  CAS  Google Scholar 

  • Jablonska, S., and Formas, I., 1959, Weitere positive Ergebnisse mit Auto-und Heteroinokulation bei Epidermodysplasia verruciformis Lewandowsky-Lutz, Dermatologica 118: 86–93.

    Article  Google Scholar 

  • Jablonska, S., and Milewski, B., 1957, Zur Kenntnis der Epidermodysplasia verruciformis, Dermatologica 115: 1–22.

    Article  PubMed  CAS  Google Scholar 

  • Jablonska, S., and Orth, G., 1985, Epidermodysplasia verruciformis, Clin. Dermatol. 3 (4): 83–96.

    Article  PubMed  CAS  Google Scholar 

  • Jablonska, S., Fabjanska, L., and Formas, I., 1966, On the viral aetiology of epidermodysplasia verruciformis, Dermatologica 132: 369–385.

    Article  PubMed  CAS  Google Scholar 

  • Jablonska, S., Biczysko, W., Jakubowicz, K., and Dabrowski, J., 1968, On the viral etiology of epidermodysplasia verruciformis Lewandowsky-Lutz: Electron microscope studies, Dermatologica 137: 113–125.

    Article  PubMed  CAS  Google Scholar 

  • Jablonska, S., Biczysko, W., Jakubowicz, K., and Dabrowski, J., 1970, The ultrastructure of transitional states to Bowen’s disease and invasive Bowen’s carcinoma in epidermodysplasia verruciformis, Dermatologica 140: 186–194.

    Article  PubMed  CAS  Google Scholar 

  • Jablonska, S., Dabrowski, J., and Jakubowicz, K., 1972, Epidermodysplasia verruciformis as a model in studies on the role of papovaviruses in oncogenesis, Cancer Res. 32: 583–589.

    PubMed  CAS  Google Scholar 

  • Jablonska, S., Orth, G., Jarzabek-Chorzelska, M., Glinski, W., Obalek, S., Rzesa, G., Croissant, O., and Favre, M., 1979a, Twenty-one years of follow-up studies of familial epidermodysplasia verruciformis, Dermatologica 158: 309–327.

    Article  PubMed  CAS  Google Scholar 

  • Jablonska, S., Orth, G., Jarzabek-Chorzelska, M., Rzesa, G., Obalek, S., Glinski, W., Favre, M., and Croissant, O., 1979b, Epidermodysplasia verruciformis versus disseminated varrucae planae: Is epidermodysplasia verruciformis a generalized infection with wart virus? J. Invest. Dermatol. 72: 114–119.

    Article  PubMed  CAS  Google Scholar 

  • Jablonska, S., Orth, G., and Lutzner, M. A., 1982a, Immunopathology of papillomavirusinduced tumors in different tissues, Springer Semin. Immunopathol. 5: 33–62.

    Article  PubMed  CAS  Google Scholar 

  • Jablonska, S., Obalek, S., Orth, G., Haftek, M., and Jarzabek-Chorzelska, M., 1982b, Regression of the lesions of epidermodysplasia verruciformis, Br. J. Dermatol. 107: 109–116.

    Article  PubMed  CAS  Google Scholar 

  • Jablonska, S., Orth, G., Obalek, S., and Croissant, O., 1985, Cutaneous warts: Clinical, histologic, and virologie correlations, Clin. Dermatol. 3 (4): 71–82.

    Article  PubMed  CAS  Google Scholar 

  • Jacyk, W. K., and Lechner, W., 1984, Epidermodysplasia verruciformis in lepromatous leprosy: Report of 2 cases, Dermatologica 168: 202–205.

    Article  PubMed  CAS  Google Scholar 

  • Jacyk, W. K., and Subbuswamy, S. G., 1979, Epidermodysplasia verruciformis in Nigerians, Dermatologica 159: 256–265.

    Article  PubMed  CAS  Google Scholar 

  • Johnson, S. A., Montgomery, H., Tuura, J. L., and Winkelmann, R. K., 1962, Two cases of unusual vacuolar degeneration of the epidermis, Arch. Dermatol. 85: 93–104.

    Article  Google Scholar 

  • Kaminski, M., Pawinska, M., Jablonska, S., Szmurlo, A., Majewski, S., and Orth, G., 1985, Increased natural killer activity in patients with epidermodysplasia verruciformis, Arch. Dermatol. 121: 84–86.

    Article  PubMed  CAS  Google Scholar 

  • Kaufmann, J., Meves, C., and Ott, F., 1978, Die Epidermodysplasia verruciformis Lewandowsky-Lutz in licht-und elektronenoptischen Vergleich mit den übrigen Papova-VirusAcanthomen, Arch. Dermatol. Res. 261: 39–54.

    Article  PubMed  CAS  Google Scholar 

  • Kawashima, M., Jablonska, S., Favre, M., Obalek, S., Croissant, O., and Orth, G., 1986a, Characterization of a new type of human papillomavirus found in a lesion of Bowen’s disease of the skin, J. Virol. 57: 688–692.

    PubMed  CAS  Google Scholar 

  • Kawashima, M., Favre, M., Jablonska, S., Obalek, S., and Orth, G., 1986b, Characterization of a new type of human papillomavirus (HPV) related to HPV5 from a case of actinic keratosis, Virology 54: 389–394.

    Article  Google Scholar 

  • Kienzler, J. L., Laurent, R., Coppey, J., Favre, M., Orth, G., Coupez, L., and Agache, P., 1979, Epidermodysplasie verruciforme: Données ultrastructurales, virologiques et photo-biologiques; à propos d’une observation, Ann. Dermatol. Venereol. 106: 549–563.

    PubMed  CAS  Google Scholar 

  • Kienzler, J. L., Lemoine, M. T., Orth, G., Jibard, N., Blanc, D., Laurent, R., and Agache, P., 1983, Humoral and cell-mediated immunity to human papillomavirus type 1 (HPV-l) in human warts, Br. J. Dermatol. 108: 665–672.

    Article  PubMed  CAS  Google Scholar 

  • Kinlen, L. J., Sheil, A. G. R., Peto, J., and Doll, R., 1979, Collaborative United Kingdom—Australasian study of cancer in patients treated with immunosuppressive drugs, Br. Med. J. 2: 1461–1466.

    Article  PubMed  CAS  Google Scholar 

  • Kogoj, F., 1926, Die Epidermodysplasia verruciformis, Acta Derm. Venereol. 7: 170–179.

    Google Scholar 

  • Koranda, F. C., Dehmel, E. M., Kahn, G., and Penn, I., 1974, Cutaneous complications in immunosuppressed renal homograft recipients, J. Am. Med. Assoc. 229: 419–424.

    Article  CAS  Google Scholar 

  • Kremsdorf, D., 1980, Clonage et construction d’une carte physique du génome de trois papillomavirus humains associés à la forme grave de l’épidermodysplasie verruciforme, D. E. A. Microbiol. Université Paris 6.

    Google Scholar 

  • Kremsdorf, D., Jablonska, S., Favre, M., and Orth, G., 1982a, Biochemical characterization of two types of human papillomaviruses associated with epidermodysplasia verruciformis, J. Virol. 43: 436–447.

    PubMed  CAS  Google Scholar 

  • Kremsdorf, D., Jablonska, S., Favre, M., and Orth, G., 1982b, Abstracts of papers presented at the Cold Spring Harbor Meeting on Papilloma Viruses, Cold Spring Harbor, N. Y., pp. 91–96.

    Google Scholar 

  • Kremsdorf, D., Jablonska, S., Favre, M., and Orth, G., 1983, Human papillomaviruses associated with epidermodysplasia verruciformis. II. Molecular cloning and biochemical characteriation of human papillomavirus 3a, 8, 10, and 12 genomes, J. Virol. 48: 340–351.

    PubMed  CAS  Google Scholar 

  • Kremsdorf, D., Favre, M., Jablonska, S., Obalek, S., Rueda, L. A., Lutzner, M. A., Blanchet-Bardon, C., Van Voorst Vader, P. C., and Orth, G., 1984, Molecular cloning and characterization of the genomes of nine newly recognized human papillomavirus types associated with epidermodysplasia verruciformis, J. Virol. 52: 1013–1018.

    PubMed  CAS  Google Scholar 

  • Kripke, M. L., and Morrison, W. L., 1985, Modulation of immune function by UV radiation, J. Invest. Dermatol. 85: 62s - 66s.

    Article  PubMed  CAS  Google Scholar 

  • Langner, A., Jablonska, S., and Darzynkiewicz, Z., 1968, Autoradiographic study of DNA synthesis by epidermal cells in epidermodysplasia verruciformis, Acta Derm. Venereol. 48: 501–506.

    PubMed  CAS  Google Scholar 

  • Laurent, R., Coume-Marquet, S., Kienzler, J. L., Lambert, D., and Agache, P., 1978, Comparative electron microscopic study of clear cells in epidermodysplasia verruciformis and flat warts, Arch. Dermatol. Res. 263: 1–12.

    Article  Google Scholar 

  • Lazzaro, C., Giardina, A, and Randazzo, S. D., 1966, Sulla epidermodisplasia verruciforme di Lewandowski—Lutz, Minerva Dermatol. 41: 4–13.

    PubMed  CAS  Google Scholar 

  • Lever, W. F., and Schaumburg-Lever, G. A., 1975, Tumors and cysts of the epidermis, in: Histopathology of the Skin, 5th ed., pp. 450–497, Lippincott, Philadelphia.

    Google Scholar 

  • Lewandowsky, F., and Lutz, W., 1922, Ein Fall einer bisher nicht beschriebenen Hauterkrankung (Epidermodysplasia verruciformis, Arch. Dermatol. Syphilol. 141: 193–203.

    Google Scholar 

  • Lutz, W. A., 1946, A propos de l’épidermodysplasie verruciforme, Dermatologica 92: 30–43.

    Article  PubMed  CAS  Google Scholar 

  • Lutzner, M. A., 1978, Epidermodysplasia verruciformis: An autosomal recessive disease characterized by viral warts and skin cancer. A model for viral oncogenesis, Bull. Cancer 65: 169–182.

    PubMed  CAS  Google Scholar 

  • Lutzner, M. A., 1985, Papillomavirus lesions in immunodepression and immunosuppression, Clin. Dermatol. 3 (4): 165–169.

    Article  PubMed  CAS  Google Scholar 

  • Lutzner, M., Croissant, O., Ducasse, M. F., Kreis, H., Crosnier, J., and Orth, G., 1980, A potentially oncogenic human papillomavirus (HPV-5(found in two renal allograft recipients, J. Invest. Dermatol. 75: 353–356.

    Article  PubMed  CAS  Google Scholar 

  • Lutzner, M. A., Orth, G., Dutronquay, V., Ducasse, M. F., Kreis, H., and Crosnier, J., 1983, Detection of human papillomavirus type 5 DNA in skin cancers of an immunosuppressed renal allograft recipient, Lancet 2: 422–424.

    Article  PubMed  CAS  Google Scholar 

  • Lutzner, M. A., Blanchet-Bardon, C., and Orth, G., 1984, Clinical observations, virologic studies, and treatment trials in patients with epidermodysplasia verruciformis, a disease induced by specific human papillomaviruses, J. Invest. Dermatol. 83: 18s - 25s.

    Article  PubMed  CAS  Google Scholar 

  • Marill, F. G., and Grould, P., 1967, Epidermodysplasie verruciforme de Lewandowsky—Lutz avec transformation épitheliomateuse, Bull. Soc. Fr. Dermatol. Syphiligr. 74: 213–215.

    PubMed  CAS  Google Scholar 

  • Marshall, V., 1974, Premalignant and malignant skin tumours in immunosuppressed patients, Transplantation 17: 272–275.

    Article  PubMed  CAS  Google Scholar 

  • Maschkilleisson, L. N., 1931, Ist die Epidermodysplasia verruciformis (Lewandowsky—Lutz) eine selbständige Dermatose? Ihre Beziehungen zur Verrucositas, Dermatol. Wochenschr. 92: 569–578.

    Google Scholar 

  • Midana, A., 1949, Sulla questione dei rapporti tra epidermodysplasia verruciformis e verrucosi generalizzata: Osservazioni su 4 casi di E. V. a carattere famigliare, Dermatologica 99: 1–23.

    Article  PubMed  CAS  Google Scholar 

  • Moreno, G., and Pruniéras, M., 1974, Epidermodysplasia verruciformis. III. Ultraviolet micro-irradiation of cells in culture, Arch. Dermatol. Forsch. 249: 247–254.

    PubMed  CAS  Google Scholar 

  • Mullen, D. L., Silverberg, S. G., Penn, I., and Hammond, W. S., 1976, Squamous cell carcinoma of the skin and lip in renal homograft recipients, Cancer 37: 729–734.

    Article  PubMed  CAS  Google Scholar 

  • Nash, A. A., 1985, Tolerance and suppression in viral diseases, Br. Med. Bull. 41: 41–45.

    PubMed  CAS  Google Scholar 

  • Nasseri, M., and Wettstein, F. O., 1984, Viral transcripts in cottontail rabbit papillomavirusinduced tumors: Differences exist between benign and malignant as well as between non-virus-producing and virus-producing tumors, J. Virol. 51: 706–712.

    PubMed  CAS  Google Scholar 

  • Oehlschlaegel, G., Röckl, H., and Müller, E., 1966, Die Epidermodysplasia verruciformis, ein Sog. Praecancerose, Hautarzt 10: 450–458.

    Google Scholar 

  • Okamoto, T., Yabe, Y., and Ohmori, S., 1970, Virus-like particles in rhabdomyosarcoma with epidermodysplasia verruciformis, Dermatologica 141: 309–314.

    Article  PubMed  CAS  Google Scholar 

  • Orth, G., 1986, Epidermodysplasia verruciformis, a model for understanding the oncogenicity of human papillomaviruses, Ciba Found. Symp. 120: 157–174.

    PubMed  CAS  Google Scholar 

  • Orth, G., and Favre, M., 1985, Human papillomaviruses: Biochemical and biologic properties, Clin. Dermatol. 3 (4): 27–42.

    Article  PubMed  CAS  Google Scholar 

  • Orth, G., Favre, M., and Croissant, O., 1977a, Characterization of a new type of human papillomavirus that causes skin warts, J. Virol. 24: 108–120.

    PubMed  CAS  Google Scholar 

  • Orth, G., Breitburd, F., Favre, M., and Croissant, O., 1977b, Papilloma viruses: Possible role in human cancer, Cold Spring Harbor Conf. Cell Prolif. 4: 1043–1068.

    Google Scholar 

  • Orth, G., Favre, M., Jablonska, S., Brylak, K., and Croissant, O., 1978a, Viral sequences related to a human skin papillomavirus in genital warts, Nature 275: 334–336.

    Article  PubMed  CAS  Google Scholar 

  • Orth, G., Jablonska, S., Breitburd, F., Favre, M., and Croissant, O., 1978b, The human papillomaviruses, Bull. Cancer 65: 151–164.

    PubMed  CAS  Google Scholar 

  • Orth, G., Jablonska, S., Favre, M., Croissant, O., Jarzabek-Chorzelska, M., and Rzesa, G., 1978c, Characterization of two types of human papillomaviruses in lesions of epidermodysplasia verruciformis, Proc. Natl. Acad. Sci. USA 75: 1537–1541.

    Article  PubMed  CAS  Google Scholar 

  • Orth, G., Jablonska, S., Jarzabek-Chorzelska, M., Rzesa, G., Obalek, S., Favre, M., and Croissant, O., 1979, Characteristics of the lesions and risk of malignant conversion as related to the type of the human papillomavirus involved in epidermodysplasia verruciformis, Cancer Res. 39: 1074–1082.

    PubMed  CAS  Google Scholar 

  • Orth, G., Favre, M., Breitburd, F., Croissant, O., Jablonska, S., Obalek, S., Jarzabek-Chorzelska, M., and Rzesa, G., 1980, Epidermodysplasia verruciformis: A model for the role of papillomaviruses in human cancer, Cold Spring Harbor Conf. Cell Prolif. 7: 259–282.

    CAS  Google Scholar 

  • Orth, G., Jablonska, S., Favre, M., Croissant, O., Obalek, S., Jarzabel-Chorzelska, M., and Jibard, N., 1981, Identification of papillomaviruses in butchers’ warts, J. Invest. Dermatol. 76: 97–102.

    Article  PubMed  CAS  Google Scholar 

  • Ostrow, R. S., Bender, M., Niimura, M., Seki, T., Kawashima, M., Pass, F., and Faras, A. J., 1982, Human papillomavirus DNA in cutaneous primary and metastasized squamous cell carcinoma from patients with epidermodysplasia verruciformis, Proc. Natl. Acad. Sci. USA 79: 1634–1638.

    Article  PubMed  CAS  Google Scholar 

  • Ostrow, R., Zachow, K., Watts, S., Bender, M., Pass, F., and Faras, A., 1983a, Characterization of two HPV3-related papillomaviruses from common warts that are distinct clinically from flat warts or epidermodysplasia verruciformis, J. Invest. Dermatol. 80: 436–440.

    Article  PubMed  CAS  Google Scholar 

  • Ostrow, R. S., Watts, S., Bender, M., Niimura, M., Seki, T., Kawashima, M., Pass, F., and Faras, A. J., 1983b, Identification of three distinct papillomavirus genomes in a single patient with epidermodysplasia verruciformis, J. Am. Acad. Dermatol. 8: 398–404.

    Article  PubMed  CAS  Google Scholar 

  • Ostrow, R. S., Zachow, K. R., Thompson, O., and Faras, A. J., 1984, Molecular cloning and characterization of a unique type of human papillomavirus from an immune deficient patient, J. Invest. Dermatol. 82: 362–366.

    Article  PubMed  CAS  Google Scholar 

  • Ostrow, R. S., Zachow, K. R., Niimura, M., Okagaki, T., Muller, S., Bender, M., and Faras, A. J., 1986, Detection of papillomavirus DNA in human semen, Science 231: 731–733.

    Article  PubMed  CAS  Google Scholar 

  • Pass, F., Reissig, M., Shah, K. V., Eisinger, M., and Orth, G., 1977, Identification of an immunologically distinct papillomavirus from lesions of epidermodysplasia verruciformis, J. Natl. Cancer Inst. 59: 1107–1112.

    PubMed  CAS  Google Scholar 

  • Penn, I., 1980, Immunosuppression and skin cancer, Clin. Plast. Surg. 7: 361–368.

    PubMed  CAS  Google Scholar 

  • Pfister, H., and Haneke, E., 1984, Demonstration of human papilloma virus type 2 DNA in Bowen’s disease, Arch. Dermatol. Res. 276: 123–125.

    Article  PubMed  CAS  Google Scholar 

  • Pfister, H., Gross, G., and Hagedorn, M., 1979, Characterization of human papillomavirus 3 in warts of a renal allograft patient, J. Invest. Dermatol. 73: 349–353.

    Article  PubMed  CAS  Google Scholar 

  • Pfister, H., Nürnberger, F., Gissmann, L., and zur Hausen, H., 1981, Characterization of a human papillomavirus from epidermodysplasia verruciformis lesions of a patient from Upper Volta, Int. J. Cancer 27: 645–650.

    Article  PubMed  CAS  Google Scholar 

  • Pfister, H., Gassenmaier, A., Nürnberger, F., and Stüttgen, G., 1983, Human papillomavirus 5-DNA in carcinoma of an epidermodysplasia verruciformis patient infected with various human papillomavirus types, Cancer Res. 43: 1436–1441.

    PubMed  CAS  Google Scholar 

  • Pfister, H., Iftner, T., and Fuchs, P. G., 1985, Papillomaviruses from epidermodysplasia verruciformis patients and renal allograft recipients, in: Papillomaviruses: Molecular and Clinical Aspects ( P. M. Howley and T. R. Broker, eds.), pp. 85–100, Liss, New York.

    Google Scholar 

  • Prawer, S. E., Pass, F., Vance, J. C., Greenberg, L. J., Yunis, E. J., and Zelickson, A. S., 1977, Depressed immune function in epidermodysplasia verruciformis, Arch. Dermatol. 113: 495–499.

    Article  PubMed  CAS  Google Scholar 

  • Proniewska, M., and Jablonska, S., 1980, UV-induced DNA repair synthesis in patients with epidermodysplasia verruciformis, Dermatologica 160: 289–296.

    Article  PubMed  CAS  Google Scholar 

  • Pruniéras, M., 1975, Ultrastructure of the epidermis in epidermodysplasia verruciformis (EV), in: Biomedical Aspects of Human Wart Infection ( M. Pruniéras, ed.), pp. 165–170, Fondation Mérieux, Lyon.

    Google Scholar 

  • Prystowsky, S. O., Herndon, J. H., and Freeman, R. G., 1976, Epidermodysplasia verruciformis, Am. J. Dis. Child. 130: 437–440.

    PubMed  CAS  Google Scholar 

  • Pyrhönen, S., Jablonska, S., Obalek, S., and Kuismanen, E., 1980, Immune reactions in epidermodysplasia verruciformis, Br. J. Dermatol. 102: 247–254.

    Article  PubMed  Google Scholar 

  • Rajagopalan, K., Bahru, J., Loo, D. S., Tay, C. H., Chin, K. N., and Tan, K. K., 1972, Familial epidermodysplasia verruciformis of Lewandowsky and Lutz, Arch. Dermatol. 105: 73–78.

    Article  PubMed  CAS  Google Scholar 

  • Relias, A., Sakellariou, G., and Tsoïtis, G., 1967, Epidermodysplasie verruciforme de Le- wandowsky—Lutz à multiples épithéliomas, Ann. Dermatol. Syphiligr. 94: 501–514.

    CAS  Google Scholar 

  • Riou, G., Barrois, M., Dutronquay, V., and Orth, G., 1985, Presence of papillomavirus DNA sequences, amplification of c-myc and c-Ha-ras cncogenes and enhanced expression of c-myc in carcinomas of the uterine cervix, in: Papillomaviruses: Molecular and Clinical Aspects ( P. M. Howley and T. R. Broker, eds.), pp. 47–56, Liss, New York.

    Google Scholar 

  • Rogers, S., and Rous, P., 1951, Joint action of a chemical carcinogen and a neoplastic virus to induce cancer in rabbits, J. Exp. Med. 93: 459–487.

    Article  PubMed  CAS  Google Scholar 

  • Rous, P., and Beard, J. W., 1935, The progression to carcinoma of virus-induced rabbit papillomas (Shope), J. Exp. Med. 62: 523–548.

    Article  PubMed  CAS  Google Scholar 

  • Rous, P., and Friedewald, W. F., 1944, The effect of chemical carcinogens on virus-induced rabbit papillomas, J. Exp. Med. 79: 511–538.

    Article  PubMed  CAS  Google Scholar 

  • Rüdlinger, R., Smith, I. W., Bunney, M. H., and Hunter, J. A. A., 1986, Human papillomavirus infections in a group of renal transplant patients, Br. J. Dermatol. (in press).

    Google Scholar 

  • Rüdlinger, R., Bunney, M. H., Smith, I. W., and Hunter, J. A. A., 1987, Detection of human papillomavirus type 5 DNA in a renal allograft patient from Scotland, Arch. Dermatol. (manuscript submitted).

    Google Scholar 

  • Rueda, L. A., and Rodriguez, G., 1972, Comparacion di la virogenesis en la epidermodisplasia verruciforme y en las verrugas planas, Med. Cutan. Iber. Lat. Am. 6: 451–457.

    Google Scholar 

  • Rueda, L. A., and Rodriguez, G., 1976, Verrugas humanas por virus papova: Correlacion clinica, histologica y ultraestructural, Med. Cutan. Iber. Lat. Am. 2: 113–136.

    Google Scholar 

  • Rueda, L. A., and Rodriguez, G., 1983, Histopathology and ultrastructure of epidermodysplasia verruciformis, in: Proceedings of the XVIth International Congress of Dermatology ( A. Kukita and M. Seiji, eds.), pp. 617–620, University of Tokyo Press, Tokyo.

    Google Scholar 

  • Ruiter, M., 1969, Malignant degeneration of skin lesions in epidermodysplasia verruciformis, Acta Derm. Venereol. 49: 309–313.

    PubMed  CAS  Google Scholar 

  • Ruiter, M., 1973, On the histomorphology and origin of malignant cutaneous changes in epidermodysplasia verruciformis, Acta Dem. Venereol. 53: 290–298.

    CAS  Google Scholar 

  • Ruiter, M., and Van Mullem, P. J., 1966, Demonstration by electronmicroscopy of an intranuclear virus in epidermodysplasia verruciformis, J. Invest. Dermatol. 47: 247–252.

    PubMed  CAS  Google Scholar 

  • Ruiter, M., and Van Mullem, P. J., 1970a, Behavior of virus in malignant degeneration of skin lesions in epidermodysplasia verruciformis, J. Invest. Dermatol. 54: 324–331.

    Article  PubMed  CAS  Google Scholar 

  • Ruiter, M., and Van Mullem, P. J., 1970b, Further histological investigations on malignant degeneration of cutaneous lesions in epidermodysplasia verruciformis, Acta Derm. Venereol. 50: 205–211.

    PubMed  CAS  Google Scholar 

  • Sanderson, K. V., and Mackie, R. M., 1979, Tumours of the skin, in: Textbook of Dermatology (A. J. Rook, D. S. Wilkinson, and F. J. Ebling, eds.), 3rd ed., Vol. 2, pp. 2129–2231, Blackwell, Oxford.

    Google Scholar 

  • Sayag, J., Muratore, R., Olmer, J., and Hadida, E., 1966, Epidermodysplasie verruciforme et réticulose ganglionnaire maligne, Bull. Soc. Fr. Dermatol. Syphiligr. 73: 313–315.

    PubMed  CAS  Google Scholar 

  • Schellander, F., and Fritsch, P., 1970, Epidermodysplasia verruciformis: Neue Aspekte zur Symptomatologie und Pathogenese, Dermatologica 140: 251–263.

    Article  PubMed  CAS  Google Scholar 

  • Scheurlen, W., Gissmann, L., Gross, G., and zur Hausen, H., 1986, Molecular cloning of two new HPV-types (HPV37 and HPV38) from a keratoacanthoma and a malignant melanoma, Int. J. Cancer 37: 505–510.

    Article  PubMed  CAS  Google Scholar 

  • Schwarz, E., Freese, U. K., Gissmann, L., Mayer, W., Roggenbuck, B., Stremlau, A., and zur Hausen, H., 1985, Structure and transcription of human -papillomavirus sequences in cervical carcinoma cells, Nature 314: 111–114.

    Article  PubMed  CAS  Google Scholar 

  • Seedorf, K., Krämmer, G., Thirst, M., Suhai, S., and Röwekamp, W. G., 1985, Human papillomavirus type 16 DNA sequence, Virology 145: 181–185.

    Article  PubMed  CAS  Google Scholar 

  • Spencer, E. S., and Andersen, H. K., 1979, Viral infections in renal allograft recipients treated with long-term immunosuppression, Br. Med. J. 2: 829–830.

    Article  PubMed  CAS  Google Scholar 

  • Spradbrow, P. B., Beardmore, G. L., and Francis, J., 1983, Virions resembling papillomaviruses in hyperkeratotic lesions from sun-damaged skin, Lancet 1: 189.

    Article  PubMed  CAS  Google Scholar 

  • Streilen, J. W., 1983, Skin-associated lymphoid tissues (SALT): Origins and functions, J. Invest. Dermatol. 80: 12s - 16s.

    Article  Google Scholar 

  • Streilen, J. W., 1985, Circuits and signals of the skin-associated lymphoid tissues (SALT), J. Invest. Dermatol. 85: 10s - 13s.

    Article  Google Scholar 

  • Sullivan, M., and Ellis, F A, 1939, Epidermodysplasia verruciformis (Lewandowsky and Lutz), Arch. Dermatol. Syphilol. 40: 422–432.

    Article  Google Scholar 

  • Syverton, J. T., 1952, The pathogenesis of the rabbit papilloma-to-carcinoma sequence, Ann. N. Y. Acad. Sci. 54: 1126–1140.

    Article  PubMed  CAS  Google Scholar 

  • Tagami, H., Aiba, S., and Rokugo, M., 1985a, Regression of flat warts and common warts, Clin. Dermatol. 3 (4): 170–178.

    Article  PubMed  CAS  Google Scholar 

  • Tagami, H., Oku, T., and Iwatsuki, K., 1985b, Primary tissue culture of spontaneously regressing flat warts, Cancer 55: 2437–2441.

    Article  PubMed  CAS  Google Scholar 

  • Taichman, L. B., Breitburd, F., Croissant, O., and Orth, G., 1984, The search for a culture system for papillomavirus, J. Invest. Dermatol. 83: 2s - 6s.

    Article  PubMed  CAS  Google Scholar 

  • Tsoitis, G., Destombes, P., Ravisse, P., and Ancelle, G., 1973, Epidermodysplasie verruciforme de Lewandowsky—Lutz observée chez un Camerounais, Bull. Soc. Pathol. Exot. 66: 411–426.

    CAS  Google Scholar 

  • Tsumori, T., Yutsudo, M., Nakano, Y., Tanigaki, T., Kitamura, H., and Hadura, A., 1983, Molecular cloning of a new human papillomavirus isolated from epidermodysplasia verruciformis lesions, J. Gen. Virol. 64: 967–969.

    Article  PubMed  CAS  Google Scholar 

  • Urbach, F., 1982, Epidemiology and etiology of skin cancer in man, in: Cancer Campaign, Vol. 6, Cancer Epidemiology ( E. Grundmann, ed.), pp. 213–227, Gustav Fischer Verlag, Stuttgart/New York.

    Google Scholar 

  • Van Voorst Vader, P. C., Orth, G., Dutronquay, V., Driessen, L. H. H. M., Eggink, H. F., Kallenberg, L. G. M., and The, T. H., 1986, Epidermodysplasia verruciformis: Skin carcinoma containing human papillomavirus type 5 DNA sequences and primary hepatocellular carcinoma associated with chronic hepatitis B virus infection in a patient, Acta Derm. Venereol. 66: 231–236.

    PubMed  Google Scholar 

  • Vasily, D. B., Miller, O. F., Fudenberg, H. H., Goust, J. M., and Wilson, G. B., 1984, Epidermodysplasia verruciformis: Response to therapy with dialyzable leukocyte extract (transfer factor) derived from household contacts, J. Clin. Lab. Immunol. 14: 49–57.

    PubMed  CAS  Google Scholar 

  • Vogel, F., and Motulsky, A. G., 1982, Human Genetics: Problems and Approaches, Springer-Verlag, Berlin.

    Google Scholar 

  • Waisman, M., and Montgomery, H., 1942, Verruca plana and epithelial nevus, including a study of epidermodysplasia verruciformis, Arch. Dermatol. Syphilol. 45: 259–279.

    Article  Google Scholar 

  • Watts, S. L., Phelps, W. C., Ostrow, R. S., Zachow, K. R., and Faras, A. J., 1984, Cellular transformation by human papillomavirus DNA in vitro, Science 225: 634–636.

    Article  PubMed  CAS  Google Scholar 

  • Watts, S. L., Chow, L. T., Ostrow, R. S., Faras, A. J., and Broker, T. R., 1985, Localization of HPV-5 transforming functions, in: Papillomaviruses: Molecular and Clinical Aspects ( P. M. Howley and T. R. Broker, eds.), pp. 501–511, Liss, New York.

    Google Scholar 

  • Wettstein, F. O., and Stevens, J. G., 1982, Variable-sized free episomes of Shope papilloma virus DNA are present in all non-virus-producing neoplasms and integrated episomes are detected in some, Proc. Natl. Acad. Sci. USA 79: 790–794.

    Article  PubMed  CAS  Google Scholar 

  • Wojtulewicz-Kurkus, J., Glinski, W., Jablonska, S., Podobinska, I., and Obalek, S., 1985, Identification of HLA antigens in familial and non-familial epidermodysplasia verruciformis, Dermatologica 170: 53–58.

    Article  PubMed  CAS  Google Scholar 

  • Yabe, Y., and Sadakane, H., 1975, The virus of epidermodysplasia verruciformis: Electron microscopic and fluorescent antibody studies, J. Invest. Dermatol. 65: 324–330.

    Article  PubMed  CAS  Google Scholar 

  • Yabe, Y., Yasui, M., Yoshino, N., Fujiwara, T., Ohkuma, N., and Nohara, N., 1978, Epidermodysplasia verruciformis: Viral particles in early malignant lesions, J. Invest. Dermatol. 71: 225–228.

    Article  PubMed  CAS  Google Scholar 

  • Yee, C., Krishnan-Hewlett, I., Baker, C. C., Schlegel, R., and Howley, P. M., 1985, Presence and expression of human papillomavirus sequences in human cervical carcinoma cell lines, Am. J. Pathol. 119: 361–366.

    PubMed  CAS  Google Scholar 

  • Yutsudo, M., Tanigaki, T., Tsumori, T., Watanabe, S., and Hakura, A., 1982, New human papilloma virus isolated from epidermodysplasia verruciformis lesions, Cancer Res. 42: 2440–2443.

    PubMed  CAS  Google Scholar 

  • Yutsudo, M., Shimakage, T., and Hakura, A., 1985, Human papillomavirus type 17 DNA in skin carcinoma tissue of a patient with epidermodysplasia verruciformis, Virology 144: 295–298.

    Article  PubMed  CAS  Google Scholar 

  • zur Hausen, H., 1982, Human genital cancer: Synergism between two virus infections or synergism between a virus infection and initiating events? Lancet 1: 1370–1372.

    Article  Google Scholar 

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  1. Unité des Papillomavirus, Unité INSERM 190, Institut Pasteur, 75724, Paris Cedex 15, France

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Orth, G. (1987). Epidermodysplasia Verruciformis. In: Salzman, N.P., Howley, P.M. (eds) The Papovaviridae. The Viruses. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0584-3_8

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