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Papillomavirus Transformation

  • Chapter
The Papovaviridae

Part of the book series: The Viruses ((VIRS))

Abstract

The papillomaviruses have been studied extensively since the early 1930s when Shope initiated his studies on CRPV (Shope, 1933). Detailed studies on the biology and molecular genetics of this group of viruses have been severely hampered, however, due in large part to the lack of a tissue culture system for the in vitro propagation of these viruses. Cellular transformation of rodent cells by some papillomaviruses has provided cell culture systems for investigators to study the viral functions involved in cellular proliferation, cellular transformation, and plasmid maintenance. Although a few studies have now demonstrated transformation with certain of the HPV types, the analysis of papillomavirus-transforming functions has largely been performed with a subgroup of papillomaviruses which are able to induce fibroblastic tumors in hamsters. These viruses are listed in Table I. Of these, BPV-1 is the best studied. BPV-1 can induce fibroblastic tumors in a variety of heterologous hosts other than hamsters, including horses (Olson et al., 1969; Lancaster et al., 1977), mice (Boiron et al., 1964), and pika (Puget et al., 1975). One characteristic of the viruses listed in Table I is that each induces fibropapillomas consisting of a proliferative fibroblastic component as well as a proliferative squamous epithelial component. Thus, the ability to induce fibroblastic tumors in heterologous hosts would appear to correlate with the ability of an individual papillomavirus to induce fibroblastic proliferation as a part of the normal benign lesion induced in its natural host.

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  1. Laboratory of Tumor Virus Biology, National Cancer Institute, Bethesda, Maryland, 20892, USA

    Peter M. Howley & Richard Schlegel

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  1. Peter M. Howley
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  1. National Institutes of Health, Bethesda, Maryland, USA

    Norman P. Salzman  & Peter M. Howley  & 

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Howley, P.M., Schlegel, R. (1987). Papillomavirus Transformation. In: Salzman, N.P., Howley, P.M. (eds) The Papovaviridae. The Viruses. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0584-3_5

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  • DOI: https://doi.org/10.1007/978-1-4757-0584-3_5

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