Could a Model for the Regulation of ago-Antagonistic Couples Be Related to Various Types of Concrete Systems?

  • E. Bernard-Weil
Part of the NATO Conference Series book series (NATOCS, volume 5)


A model for the regulation of ago-antagonistic couples has been built in order to solve some physiopathological and therapeutical problems related to a special type of endocrine disorders, the unbalance which can happen within the dynamics between adrenocortical hormones (ACH) on the one hand, and antidiuretic hormone (ADH) of neuropostpituitary origin on the other hand. These hormones have antagonistic actions as far as water diuresis, water shifts in interstitial and cell body compartments, extracellular osmolarity (natremia), and also glycemia, cell growth and multiplication... are concerned; and agonistic actions as far as volemia, response to the stress... are concerned. One can admit that in the physiological state, there is a balance between both types of secretion: antagonistic balance when x — y (x = ADH action; y = ACH action, with a convenient common unit), agonistic balance when x + y = m (m = parameter). So the reference values of x and y are fixed in a model which returns to 0 the values of u = x — y and v = x + y — m after a perturbation of the system.


Circadian Rhythm Parametric Field Physiological Model Concrete System Plasma Vasopressin 
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Copyright information

© Springer Science+Business Media New York 1978

Authors and Affiliations

  • E. Bernard-Weil
    • 1
  1. 1.Neurosurgical ClinicCHU Pitié-SalpêtrièreParisFrance

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