Abstract
Endogenous C-type retroviruses are expressed morphologically and antigenically in embryos of many mammalian species (1,2). Viral DNA is inserted into the host genome and thus can be vertically transmitted from parent to offspring. In addition, the expression of these viruses is highly regulated by host genes (1). In both inbred and feral mice, C-type particles are seen consistently in developing lymphoid organs during fetal life, but disappear prior to birth (3,4). It has been reported (5) that in fetal murine thymus, C-type particles are first seen budding from reticular epithelial cells and later from thymocytes. Consequently, it has been suggested that the expression of these particles may play a role in the differentiation of normal T lymphocytes.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Aaronson, S.A.; Stephenson, J.R. Biochim Biophys Acta 458 (1976) 323.
Huebner, R.J. et al. Proc Natl Acad Sci USA 67 (1970) 366.
Mandel, T. Z Zellforsch 106 (1970) 498.
Vernon, M.L. et al. J Natl Cancer Inst 51 (1973) 1171.
Koppenheffer, T.L. et al. Am J Anat 153 (1978) 165.
Linna, T.J. Blood 31 (1968) 727.
Adner, M.M. et al. Blood 25 (1965) 511.
Berman, L.D.; Black, P.H. Prog Exp Tumor Res 16 (1972) 497.
Freeman, A.E. et al. J Natl Cancer Inst 52 (1974) 1469.
Charman, H.P. et al. J Virol 14 (1974) 910.
McGrath, M.S.; Weissman, I.L. Cell 17 (1979) 65.
McGrath, M.S. et al. Nature 285 (1980) 259.
Jenkinson, E.J. et al. Nature 284 (1980) 177.
Owen, J.J.T. et al. In: Developmental Immunobiology, ed. Solomon and Horton. Elsevier/North Holland Biomedical Press (1977) 131.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1981 Plenum Press, New York
About this chapter
Cite this chapter
Witte, P.L., Wayne Streilein, J., Shannon, W.A. (1981). C-Type Particles in Thymic Development: A Correlation with Thymic Function. In: Wayne Streilein, J., Hart, D.A., Stein-Streilein, J., Duncan, W.R., Billingham, R.E. (eds) Hamster Immune Responses in Infectious and Oncologic Diseases. Advances in Experimental Medicine and Biology, vol 134. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0495-2_40
Download citation
DOI: https://doi.org/10.1007/978-1-4757-0495-2_40
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-0497-6
Online ISBN: 978-1-4757-0495-2
eBook Packages: Springer Book Archive