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Effect of Vaccinia-Activated Macrophages on Scrapie Infection in Hamsters

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Hamster Immune Responses in Infectious and Oncologic Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 134))

Abstract

The Syrian hamster has been shown to be the animal model of choice for studies on the physicochemical nature of the scrapie agent (1). The high titers of scrapie infectivity in brain tissue and the short incubation periods in this species have decreased the time required to obtain bioassay data necessary for the detection of this unusual neuropathic agent. Relatively little attention, however, has been given to the pathogenesis of scrapie infection in the hamster. The main purpose of this study was to investigate the role of the macrophage on early events in hamsters inoculated intraperitoneally (IP) with the hamster-adapted scrapie agent.

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References

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Author information

Authors and Affiliations

  1. Department of Veterinary Science, University of Wisconsin, Madison, WI, 53706, USA

    Richard F. Marsh

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  1. Richard F. Marsh
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Editors and Affiliations

  1. The University of Texas Southwestern Medical School at Dallas, Dallas, Texas, USA

    J. Wayne Streilein , David A. Hart , Joan Stein-Streilein , William R. Duncan  & Rupert E. Billingham , , ,  & 

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© 1981 Plenum Press, New York

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Marsh, R.F. (1981). Effect of Vaccinia-Activated Macrophages on Scrapie Infection in Hamsters. In: Wayne Streilein, J., Hart, D.A., Stein-Streilein, J., Duncan, W.R., Billingham, R.E. (eds) Hamster Immune Responses in Infectious and Oncologic Diseases. Advances in Experimental Medicine and Biology, vol 134. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0495-2_32

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  • DOI: https://doi.org/10.1007/978-1-4757-0495-2_32

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-0497-6

  • Online ISBN: 978-1-4757-0495-2

  • eBook Packages: Springer Book Archive

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