Abstract
Malignant neoplasms in general acquire neo-antigens, usually called tumor-specific transplantation antigen (TSTA). Chemically induced tumors usually exhibit antigens unique to each tumor, whereas tumors induced by a virus share a common antigen specific for that virus regardless of the histological type of tumor or host species in which the tumor was induced (1–3). These TSTA invoke an immune response, mainly of cell-mediated type. The immune control or progressive growth of the tumor depends upon many factors including strength of the cellular immune response (degree of sensitization of lymphoid cells), “sneaking through” or appearance of serum blocking factor (1, 3–5), and suppressor cells (6–8). It has generally been accepted that thymus-dependent lymphocytes (T) are primarily responsible for rejection of tumors (9–15). There is considerable evidence that macrophages also contribute an important effector mechanism against tumors (16). Recently, natural killer (NK) cells are also thought to be involved in tumor surveillance (17–19). Most of the studies of effector mechanisms of tumor immunity have been carried out in vitro, using various cytotoxicity assays. To assess the role of in vivo cell-mediated immune responses in tumor immunity, two main approaches usually have been used. One consisted of studying the influence of immuno-suppression (x-irradiation, thymectomy, anti-lymphocyte serum) on the development of tumors (20–24). The alternate approach is to augment cellular immune responses either through non-specific stimulation such as Bacillus Calmette-Guerin (BCG), Corynebacterium parvum (CP), poly I:C, etc. (25–28), or through adoptive transfer of specifically sensitized lymphoid cells (29–31).
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Klein, G. Annu Rev Microbiol 20 (1966) 223.
Law, L.W. Cancer Res 26 (1966) 551.
Law, L.W. Cancer Res 29 (1969) 1.
Hellström, K.E.; Hellström, I. Adv Cancer Res 12 (1969) 167.
Prehn, R.T. Science 176 (1972) 170.
Gorczynski, R.M. J Immunol 112 (1974) 1826.
Kirchner, H. et al. J Exp Med 139 (1974) 1473.
Broder, S. et al. J Natl Cancer Inst 61 (1978) 5.
Cerottini, J.C.; Bruner, K.T. Adv Immunol 18 (1974) 67.
Herberman, R.B. et al. J Natl Cancer Inst 51 (1973) 1509.
LeClerc, J.C. et al. Int J Cancer 11 (1973) 426.
Gorczynski, R.M. J Immunol 112 (1974) 533.
Berenson, J.R. et al. J Immunol 115 (1975) 234.
Glaser, M. et al. J Immunol 116 (1976) 1507.
Blasecki, J.W. J Immunol 119 (1977) 1621.
Levy, M.H.; Wheelock, E.F. Adv Cancer Res 20 (1974) 131.
Kiessling, R.; Haller, O. In: Contemporary Topics in Immuno-biology, 8, ed. Hanna. Plenum Press, New York (1978) 171.
Herberman, R.B.; Holden, H.T. Adv Cancer Res 27 (1978) 305.
Datta, S.K. et al. Int J Cancer 23 (1979) 728.
Law, L.W.; Dawe, C.J. Proc Soc Exp Biol Med 105 (1960) 414.
Vandeputte, M. et al. Life Sci 2 (1963) 475.
Agnew, H.D. Proc Soc Exp Biol Med 125 (1967) 132.
Vandeputte, M. Transplant Proc 1 (1969) 100.
Allison, A.C.; Law, L.W. Proc Soc Exp Biol Med 127 (1968) 207.
Mathe, G. et al. Br J Cancer 23 (1969) 814.
Larson, CL. et al. Proc Soc Exp Biol Med 140 (1972) 700.
Woodruff, M.F.A. Transplant Proc 7 (1975) 229.
Vandeputte, M. et al. Eur J Cancer 6 (1970) 323.
Law, L.W. et al. Proc Natl Acad Sci USA 57 (1967) 1068.
Fefer, A. Int J Cancer 5 (1970) 327.
Vandeputte, M.; Datta, S.K. Eur J Cancer 8 (1972) 1.
Hatch, G.G. et al. Fed Proc 29 (1970) 371.
Hirsch, M.S. et al. J Immunol 108 (1972) 649.
Burton, R.C. et al. Br J Cancer 37 (1978) 806.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1981 Plenum Press, New York
About this chapter
Cite this chapter
Datta, S.K., Trentin, J.J., McCormick, K.J. (1981). Prevention of Primary Simian Adenovirus Type 7 (SA7) Tumors in Hamsters by Adoptive Transfer of Lymphoid Cells: Role of Different Cell Types. In: Wayne Streilein, J., Hart, D.A., Stein-Streilein, J., Duncan, W.R., Billingham, R.E. (eds) Hamster Immune Responses in Infectious and Oncologic Diseases. Advances in Experimental Medicine and Biology, vol 134. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0495-2_16
Download citation
DOI: https://doi.org/10.1007/978-1-4757-0495-2_16
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-0497-6
Online ISBN: 978-1-4757-0495-2
eBook Packages: Springer Book Archive