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Physiological Principles Underlying Endocrine Therapy of Breast Cancer

  • Chapter
Book cover Current Approaches to Therapy

Abstract

The subject of endocrine therapy for advanced breast cancer is certainly not new. The first demonstration of hormonal control of breast cancer was made 81 years ago when regression of metastatic tumor was produced by ovariectomy.(1) Since then, adrenalectomy and hypophysectomy have been used to achieve similar results. These ablative procedures serve to remove sources of circulating hormones which stimulate or support breast tumor growth. Alternatively, breast cancer regression can be achieved by administering large pharmacological doses of estrogen, androgen, progestin, or glucocorticoid. Historically, the choice of endocrine therapy for an individual patient has been in large part empirical, guided by certain clinical features such as menopausal status, free interval, site of the dominant lesion, and the response to any previous endocrine therapy. Since the empirical approach has been extensively reviewed in the literature, I will not dwell upon it further in this chapter. Instead, I refer the reader to several excellent books and chapters on the subject.(2–4)

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  1. Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA

    William Leo McGuire

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    William L. McGuire M.D.

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McGuire, W.L. (1977). Physiological Principles Underlying Endocrine Therapy of Breast Cancer. In: McGuire, W.L. (eds) Current Approaches to Therapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0480-8_5

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