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Membrane Physiologic Aspects of the Adjustment of Peripheral Vascular Tone

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Atherosclerotic Plaques

Part of the book series: Nato ASI Series ((NSSA,volume 219))

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Abstract

A variety of local or systemic influences regulate peripheral organ perfusion, e.g. K+ ions, pH value, noradrenaline, prostacyclin, endothelial factors (1). With the multiplicity of effectors, and since several can be changed at the same time, the question of mechanism arises. To refer to Sherrington (2), it is important to find the “final common pathway” of their integration, even in the vascular smooth muscle cell. Electrophysiology opens up one approach to this problem. Nevertheless, biochemical processes in the cell membrane and in the cell interior have a part to play, particularly when the transmembrane passage of ions is modulated by the known intracellular second messengers like Ca2+, cAMP, cGMP, GTP-binding proteins, protein kinase C and ATP (3). This study deals mainly with the regulation of smooth muscle tone by the membrane potential with voltage-gated channels predominating.

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Author information

Authors and Affiliations

  1. Institute of Physiology, Biophysical Research Group, The Free University of Berlin, 1000, Berlin 33, Germany

    Günter Siegel, Axel Walter & Frank Schnalke

  2. Institute of Physiology, The University of Rostock, 2500, Rostock 1, Germany

    Kirsten Rückborn

  3. Cardiovascular Pharmacology, Research Laboratories of Schering, 1000, Berlin 65, Germany

    Günter Stock

Authors
  1. Günter Siegel
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  2. Kirsten Rückborn
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  3. Axel Walter
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  4. Frank Schnalke
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  5. Günter Stock
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Editor information

Editors and Affiliations

  1. University of Chicago Medical Center, Chicago, Illinois, USA

    Robert W. Wissler  & Gertrud Friedman  & 

  2. Bowman-Gray School of Medicine, Winston-Salem, North Carolina, USA

    M. Gene Bond  & Michele Mercuri  & 

  3. University of Siena, Siena, Italy

    Piero Tanganelli  & Giorgio Weber  & 

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© 1991 Plenum Press, New York

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Siegel, G., Rückborn, K., Walter, A., Schnalke, F., Stock, G. (1991). Membrane Physiologic Aspects of the Adjustment of Peripheral Vascular Tone. In: Wissler, R.W., Bond, M.G., Mercuri, M., Tanganelli, P., Weber, G., Friedman, G. (eds) Atherosclerotic Plaques. Nato ASI Series, vol 219. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-0438-9_27

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  • DOI: https://doi.org/10.1007/978-1-4757-0438-9_27

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4757-0440-2

  • Online ISBN: 978-1-4757-0438-9

  • eBook Packages: Springer Book Archive

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