Abstract
Interest in a role for taurine in the maintenance of normal electrophysiology of the heart originated from the experiments of Read and Welty (16) and later, Chazov and colleagues (1). These workers showed that exogenous taurine was capable of causing the disappearance or reduction in severity of arrhythmias, principally premature ventricular contractions, in whole animals or isolated hearts administered toxic doses of catecholamines or glycosides. The proposed mechanisms for these antiarrhythmic effects of taurine have not received uniform acceptance by workers in the field, and the subject is clearly in need of much investigation.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Chazov, E.I., Malchikova, L.S., Lipina, N.V., Asafov, G.B., and Smirnov, V.N, 1974, Taurine and electrical activity of the heart, Girc. Res., 34, 35 (Suppl. III): 11–21.
Coraboeuf, E., Deroubaix, E., and Coulombe, A., 1979, Effect of tetrodotoxin on action potentials of the conducting system in the dog heart, Am. J. Physiol., 236: H561 - H567.
Crass, M.F., III, and Lombardini, J.B., 1977, Loss of cardiac muscle taurine after acute left ventricular ischemia, Life Sci., 951–958.
Crass, M.F., III, and Lombardini, J.B., 1978, Release of tissue taurine from the oxygen-deficient perfused rat heart, Proc. Soc. Exptl. Biol. Med., 157: 486–488.
Diacono, J., and Dietrich, J., 1976, Effects of taurine on the transmembrane ionic currents of rat and guinea pig ventricular fibers, Il. Farmaco-Ed. Sci., 31: 277–283.
Dolara, P., Ledda, F., Mugelli, A., Mantelli, L., Zilletti, L., Franconi, F., and Giotti, A., 1978, Effect of taurine on calcium, inotropism and electrical activity of the heart, in: “Taurine and Néurological Disorders,” A. Barbeau and R.J. Huxtable, eds., Raven Press, New York.
Gadsby, D.C., and Cranefield, P.F., 1979, Direct measurement of changes in sodium pump current in canine cardiac Purkinje fibers, Proc. Natl. Acad. Sci., 76: 1783–1787.
Grosso, D.S., and Bressler, R., 1976, Taurine and cardiac physiology, Biochem. Pharmacol., 25: 2227–2232.
Huxtable, R.J., Chubb, J., and Azari, J., 1980, Physiological and experimental regulation of taurine content in the heart, Federation Proc., 39: 2685–2690.
Jennings, R.B., Wartman, W.R., and Zudyk, Z.E., 1957, Production of area of homogenous myocardial infarction in dog, AMA Arch. Path., 63: 580–585.
Kass, R.S., and Tsien, R.W., 1976, Control of action potential duration by calcium ions in cardiac Purkinje fibers, J. Gen. Physiol., 67: 599–617.
Kline, R.P., Cohen, I., Falk, R., and Kupersmith, J., 1980, Activity-dependent extracellular K+ fluctuations in canine Purkinje fibers, Nature, 289: 68–71.
Kocsis, J.J., Kostos, V.J., and Baskin, S.I., 1976, Taurine levels in the heart tissues of various species, in: “Taurine,” R. Huxtable and A. Barbeau, eds., Raven Press, New York.
Nathan, R.D., and DeHaan, R.L., 1979, Voltage clamp analysis of embryonic heart cell aggregates, J. Gen. Physiol., 73: 175–198.
Nathan, R.D., Fung, S.J., Stocco, D.M., Barron, E.A., and Markwald, R.R., 1980, Sialic acid: regulation of electrogenesis in cultured heart cells, Am. J. Physiol., 239: C197 - C207.
Read, W.O., and Welty, J.D., 1963, Effect of taurine on epinephrine and digoxin-induced irregularities of the dog heart, J. Pharmacol. Exp. Ther., 139: 283–289.
Read, W.0., and Welty, J.D., 1976, Effect of taurine on the action potential of guinea pig papillary muscle, in: “Taurine,” R. Huxtable and A. Barbeau, eds., Raven Press, New York.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1982 Plenum Press, New York
About this chapter
Cite this chapter
Nathan, R.D., Crass, M.F. (1982). Electrophysiological Effects of Taurine in Cardiac Purkinje Fibers and Myocardial Taurine Loss during Ischemia. Is There a Relationship?. In: Huxtable, R.J., Pasantes-Morales, H. (eds) Taurine in Nutrition and Neurology. Advances in Experimental Medicine and Biology, vol 139. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0402-0_11
Download citation
DOI: https://doi.org/10.1007/978-1-4757-0402-0_11
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-0404-4
Online ISBN: 978-1-4757-0402-0
eBook Packages: Springer Book Archive