Skip to main content
SpringerLink
Log in

Radiation-Induced and Metabolism-Induced Reactions of Hypoxic Sensitizers with Cellular Molecules

  • Chapter
Advanced Topics on Radiosensitizers of Hypoxic Cells

Part of the book series: NATO Advanced Study Institutes Series ((NSSA,volume 43))

Abstract

Several nitroaromatic compounds have been shown to selectively radiosensitize hypoxic mammalian cells and various mechanisms have been proposed to account for this effect (1,2) . Most studies show that a component of the sensitizing action of these drugs is mimetic of the sensitizing action of molecular oxygen and a rapid free radical mechanism is indicated. Another component of their radio-sensitizing action is dependent upon metabolism of the drugs by hypoxic cells (3) and can be resolved by studies which vary both temperature and exposure time (4). The molecular processes associated with this “metabolism-dependent” component of radio-sensitization may also be responsible for the hypoxic cell cytotoxicity produced by the same drugs. Various “radiation-induced” and “metabolism-induced” reactions of hypoxic cell sensitizers with cellular molecules are reviewed. Addition products consisting of sensitizer and cellular macromolecules are generated by both radiation-induced and metabolism-induced reactions and could be responsible for the various biological effects of these drugs.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. G. E. Adams, Adv. Radiat. Chem. 3: 125 (1972).

    CAS  Google Scholar 

  2. J. D. Chapman, A.P. Reuvers, J. Borsa, J.S. Henderson and R.D. Migliore, Cancer Chemother. Rep., Part 1, 58:559 (1974).

    PubMed  CAS  Google Scholar 

  3. T. W. Wong, G. F. Whitmore and S. Gulyas, Radiat. Res. 75: 541 (1978).

    Article  PubMed  CAS  Google Scholar 

  4. J. D. Chapman, J. Ngan-Lee and B.E. Meeker, in: “Molecular Action and Targets for Cancer Chemotherapeutic Agents”, A. Sartorelli, ed., Academic Press, New York, p.419 (1980).

    Google Scholar 

  5. J. S. Asquith, M.E. Watts, K. Patel, C. E. Smithen and G. E. Adams, Radiat. Res., 60:108 (1974).

    Article  PubMed  CAS  Google Scholar 

  6. A. M. Rauth, and K. Kaufman, Brit. J. Radiol., 48:209 (1975).

    Article  PubMed  CAS  Google Scholar 

  7. J. Denekamp and S. R. Harris, Radiat. Res., 61:191 (1975).

    Article  PubMed  CAS  Google Scholar 

  8. J. M. Brown, Radiat. Res., 64:633 (1975).

    Article  PubMed  CAS  Google Scholar 

  9. E. J. Hall and L. Roizin-Towle, Radiology, 117:453 (1975).

    PubMed  CAS  Google Scholar 

  10. J. K. Mohindra and A. M. Rauth, Cancer Res., 36:930 (1976).

    PubMed  CAS  Google Scholar 

  11. A. Cole, R. E. Meyn, R. Chen, P. M. Corry and W. Hittelman, in: “Radiation Biology in Cancer Research”, R. E. Meyn and H. R. Withers, eds., Raven Press, New York, p.33 (1980).

    Google Scholar 

  12. D. L. Dugle, J. D. Chapman, C. J. Gillespie, J. Borsa, R. G. Webb, B. E. Meeker and A. P. Reuvers, Int. J. Radiat. Biol., 22:545 (1972).

    Article  CAS  Google Scholar 

  13. J. D. Chapman, D. L. Dugle, A. P. Reuvers, C. J. Gillespie and J. Borsa, in: “Radiation Research — Biomedical, Chemical, and Physical Perspectives”, O. F. Nygaard, H. I. Adler and W. K. Sinclair, eds., Academic Press, New York, p.752 (1975).

    Google Scholar 

  14. J. D. Chapman, C. L. Greenstock, A. P. Reuvers, E. McDonald and I. Dunlop, Radiat. Res., 53:190 (1973).

    Article  PubMed  CAS  Google Scholar 

  15. C. L. Greenstock, J. D. Chapman, J.A. Raleigh, E. Shierman and A. P. Reuvers, Radiat. Res., 59:556 (1974).

    Article  PubMed  CAS  Google Scholar 

  16. T. Alper, Radiat. Res., 5:573 (1956).

    Article  PubMed  CAS  Google Scholar 

  17. P. Howard-Flanders, Adv. Biol. Med. Phys., 5: 533 (1958).

    Google Scholar 

  18. P. Alexander, Trans. N.Y. Acad. Sci., 24:721 (1961).

    Google Scholar 

  19. J. D. Chapman, A. P. Reuvers, J. Borsa and C. L. Greenstock, Radiat. Res., 56:291 (1973).

    Article  PubMed  CAS  Google Scholar 

  20. J. S. Asquith, J. L. Foster, R. L. Willson, R. Ings and J. A. McFadzean, Brit. J. Radiol., 47:474 (1974).

    Article  PubMed  CAS  Google Scholar 

  21. J. D. Chapman, J. A. Raleigh, J. Borsa, R. G. Webb and R. Whitehouse, Int. J. Radiat. Biol., 21:475 (1972).

    Article  CAS  Google Scholar 

  22. J. A. Raleigh, J. D. Chapman, J. Borsa, W. Kremers and A. P. Reuvers, Int. J. Radiat. Biol., 23:377 (1973).

    Article  CAS  Google Scholar 

  23. G. E. Adams, E. D. Clarke, I. R. Flockhart, R. S. Jacobs, D. S. Sehmi, I. J. Stratford, P. Wardman, M. E. Watts, J. Parrick, R. G. Wallace and C.E. Smithen, Int. J. Radiat. Biol., 35: 133 (1979).

    Article  CAS  Google Scholar 

  24. P. L. Olive and D. R. McCalla, Cancer Res., 35, 781 (1975).

    PubMed  CAS  Google Scholar 

  25. D. R. McCalla, P. L. Olive and Y. Tu, in: “Fundamentals in Cancer Prevention”, P. N. Magee, ed., Univ. Press, Baltimore, p.229 (1976).

    Google Scholar 

  26. P. L. Olive and D. R. McCalla, Chem. Biol. Interact., 16:223 (1977).

    Article  PubMed  CAS  Google Scholar 

  27. A. Tonomura and M. S. Sasaki, Jpn. J. Genet., 48:291 (1973).

    Article  Google Scholar 

  28. P. L. Olive, in: “Nitrofurans: Chemistry, Metabolism, Mutagenesis and Carcinogenics”, G. T. Bryan, ed., Raven Press, New York, p.131 (1979).

    Google Scholar 

  29. B. Palcic and L. D. Skarsgard, Brit. J. Cancer 37, Suppl.III, 54 (1978).

    CAS  Google Scholar 

  30. L. Roizin-Towle, L. Roizen, E. J. Hall and J. C. Liu, abstract Radiat. Res., 74:471 (1978).

    Google Scholar 

  31. R. A. Smith, Brit. J. Cancer, 41:305 (1980).

    Article  PubMed  CAS  Google Scholar 

  32. J. E. Biaglow and R. E. Durand, Radiat. Res., 65:529 (1976).

    Article  PubMed  CAS  Google Scholar 

  33. J. E. Biaglow, Pharmacol, and Therapeutics, 10:283 (1980).

    Article  CAS  Google Scholar 

  34. D. R. McCalla, A. Reuvers and C. Kaiser, J. Bacterid., 104: 1126 (1970).

    CAS  Google Scholar 

  35. M. Morita, D. R. Feller and J. R. Gillette, Biochem. Pharmacol. 20:217 (1971).

    Article  PubMed  CAS  Google Scholar 

  36. C. H. Wong, B. C. Behrens, M. Ichikawa and G. T. Bryan, Biochem. Pharmacol., 23:3395 (1974).

    Article  Google Scholar 

  37. K. Tatsumi, S. Kitamura, H. Yoshimura and Y. Kawazol, Chem. Pharmacol. Bull., 26:1713 (1978).

    Article  CAS  Google Scholar 

  38. J. D. Chapman, J. A. Raleigh, J. E. Pedersen, J. Ngan, F. Y. Shum, B. E. Meeker and R. C. Urtasun, in: “Radiation Research”, S. Okada, M. Imamura, T. Terashima, H. Yamaguchi, eds., Jap. Assoc. Radiat. Res., Tokyo, p.885 (1979) .

    Google Scholar 

  39. E. Perez-Reyes, B. Kalyanaraman and R. P. Mason, Mol. Pharmacol., 17:239 (1980).

    PubMed  CAS  Google Scholar 

  40. J. E. Biaglow, M. E. Varnes, C. J. Koch and R. Sridhar, in: “Free Radicals and Cancer”, R. Floyd, ed., Marcel-Dekker (1981) in press.

    Google Scholar 

  41. J. E. Biaglow, Radiat. Res. (1981) in press.

    Google Scholar 

  42. M. E. Varnes, J. E. Biaglow, C. J. Koch and E. J. Hall, in: Proceedings of “Combined Modality Cancer Treatment: Radiation Sensitizers and Protectors” Conference, Key Biscayne, Florida, Oct. 1979 (1981) in press.

    Google Scholar 

  43. P. S. Jocelyn, in: “Biochemistry of the SH Group”, Academic Press, London, p.10 (1972).

    Google Scholar 

  44. J. W. Harris and J. A. Power, Radiat. Res., 56:97 (1973).

    Article  PubMed  CAS  Google Scholar 

  45. L. F. Chasseaud, Adv. Cancer Res., 29:175 (1979).

    Article  PubMed  CAS  Google Scholar 

  46. Y. C. Taylor and A. M. Rauth, Cancer Res., 38:2745 (1978).

    PubMed  CAS  Google Scholar 

  47. A. J. Vanghese and G. F. Whitmore, Cancer Res., 40:2165 (1980).

    Google Scholar 

  48. J. A. Raleigh, F. Y. Shum and S. F. Lui, Biochem. Pharmacol. (1981) in press.

    Google Scholar 

  49. J. D. Chapman, A. J. Franko and J. Sharplin, Brit. J. Cancer (1981) in press.

    Google Scholar 

  50. J. D. Chapman, A. J. Franko and C. J. Koch, in.: “Biological Bases and Clinical Implications of Tumor Radioresistance”, G. H. Fletcher, C. Nervi and H. R. Withers, eds., Masson Publ. (1981) in press.

    Google Scholar 

  51. J. D. Chapman, New Engl. J. Med., 301:1429 (1979).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Radiation Oncology, Cross Cancer Institute and Department of Radiology, University of Alberta, Edmonton, Alberta, Canada, T6G 1Z2

    J. D. Chapman, J. Ngan-Lee, C. C. Stobbe & B. E. Meeker

Authors
  1. J. D. Chapman
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. Ngan-Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. C. C. Stobbe
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. B. E. Meeker
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Bologna, Bologna, Italy

    A. Breccia

  2. Malpighi Hospital, Bologna, Italy

    C. Rimondi

  3. Institute of Cancer Research, Sutton, England

    G. E. Adams

Rights and permissions

Reprints and permissions

Copyright information

© 1982 Plenum Press, New York

About this chapter

Cite this chapter

Chapman, J.D., Ngan-Lee, J., Stobbe, C.C., Meeker, B.E. (1982). Radiation-Induced and Metabolism-Induced Reactions of Hypoxic Sensitizers with Cellular Molecules. In: Breccia, A., Rimondi, C., Adams, G.E. (eds) Advanced Topics on Radiosensitizers of Hypoxic Cells. NATO Advanced Study Institutes Series, vol 43. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0399-3_4

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-0399-3_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-0401-3

  • Online ISBN: 978-1-4757-0399-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation