Skip to main content
SpringerLink
Log in

Cardiac Protein Synthesis in Stress: Overload, Ethanol and Anoxia

  • Chapter
Heart Perfusion, Energetics, and Ischemia

Part of the book series: NATO Advanced Science Institutes Series ((NSSA,volume 62))

  • 342 Accesses

Abstract

Protein synthesis is of major importance in maintenance of cellular structure and viability. In the heart, proteins include those with structural, contractile and enzymatic function. Since changes in cardiac size, gross structure and function have long been known to occur with different stresses, the assay of protein synthesis has become of increasing importance, and the present paper will examine alterations of such synthesis in specific stresses as hemodynamic overload, anoxia and exposure to ethanol or its metabolites.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • ASCHENBRENNER, V., ZAK, R., CUTILLETA, A.F. and RABIONOWITZ, M. (1971): Effect of hypoxia on degradation of mitochondrial components in rat cardiac muscle. Am. J. Physiol. 221: 1418 – 1425.

    Google Scholar 

  • BARTSOVA, D., CHVAPIL, M., KORECKY, B., POUPA, O., RAKUSAN, K., TUREK, Z., and VISEK, M. (1969): The growth of the muscular and collagenous parts of the rat heart in various forms of cardio-megaly. J. Physiol. (Lond) 200: 285–295.

    Google Scholar 

  • BING, R.J., TILLMAS, H., FAUVEL, J., SEELER, K., and MAO, J.C. (1974): Effect of prolonged alcohol administration on calcium transport in heart muscle of the dog. Circ. Res. 35: 33–338.

    Google Scholar 

  • BUCCINO, R.H., HARRIS, E., SPANN, J.F. and SONNENBLICK, E.H. (1969): Response of myocardial connective tissue to development of experimental hypertrophy. Am. J. Physiol. 216: 425–428.

    Google Scholar 

  • EVANS, C.D., SCHREIBER, S.S., ORATZ, M. and ROTHSCHILD, M.A. (1978): Synthesis of myosin heavy and light chains in the afterloaded guinea pig right ventricle in vitro using carrier dilution method with heterologous carriers. Cardiovasc. Res. 2: 731–743.

    Article  Google Scholar 

  • EVANS, C.D., SCHREIBER, S.S., ORATZ, M. and ROTHSCHILD, M.A. (1981): Relative synthesis of cardiac contractile proteins. Evidence for synthesis from the same precursor pool. Biochem. J. 194: 673–678.

    Google Scholar 

  • GAILIS, L. and VERDY, M. (1971): Effect of ethanol and acetaldehyde on the metabolism and cellular resistance of the perfused heart. Can. J. Biochem. 49: 227–233.

    Article  Google Scholar 

  • GARLICK, P.J. (1978): An analysis of errors in estimation of the rate of protein synthesis by constant infusion of labeled amino acid. Biochem. J. 176: 402–405.

    Google Scholar 

  • GOLBERG, A.L. and GOODMAN, H.M. (1969): Amino acid transport during work induced growth of skeletal muscle. Am. J. Physiol. 216: 111–115.

    Google Scholar 

  • HEARSE, D.J. (1977): Reperfusion of the ischemic myocardium. J. Mol. Cell. Cardiol. 9: 605–613.

    Article  Google Scholar 

  • HIROTA, Y., BING, O.H.L. and ABELMAN, W.H. (1976): Effect of ethanol in contraction and relaxation of isolated rate ventricular muscle. J. Mol. Cell. Cardiol. 8: 727–732.

    Article  Google Scholar 

  • HIDER, R.C., FERN, E.B. and LONDON, D.R. (1971): Identification in skeletal muscle of a distinct extracellular pool of amino acids and its role in protein synthesis. Biochem. J. 121: 817–827.

    Google Scholar 

  • ILAN, J. and SINGER, M. (1975): Sampling of the leucine pool from the growing peptide chain. Difference in leucine specific activity of peptidyl transfer tRNA from free and membrane bound polysomes. J. Mol. Biol. 91; 39–51.

    Article  Google Scholar 

  • JEFFERSON, L.S., WOLPERT, E.B., GIGER, K.E. and MORGAN, H.E. (1971): Regulation of protein synthesis in heart muscle III. Effect of anoxia on protein synthesis. J. Biol. Chem. 246: 2171–2178.

    Google Scholar 

  • JENNINGS, R.B. and GANOE, C.E. (1974): Structural changes in myocardium during acute ischemia. Circ. Res. 34 (Suppl. III): 156–172.

    Google Scholar 

  • KORSTEIN, M.D., MATSUSAKI, S., FEINMAN, L. and LIEBER, C.S. (1975): High blood acetaldehyde levels after ethanol administration. N. Engl. J. Med. 292: 386–389.

    Article  Google Scholar 

  • LAGRANGE, B.M. and LOW, R.B. (1976): Turnover of myosin heavy and light chains in cultured embryonic chick cardiac and skeletal muscle. Dev. Biol. 54: 214–229.

    Article  Google Scholar 

  • LESCH, M., GORLIN, R., and SONNENBLICK, E.H. (1970): Myocardial amino acid transport in the isolated rabbit right ventricular papillary muscle. Circ, Res. 27: 445–460.

    Google Scholar 

  • LIEBER, C.S., SPRITZ, N., and DECARLI, L.M. (1966): Accumulation of triglycerides in heart and kidney after alcohol ingestion. J. Clin. Invest. 45: 1041–1051.

    Google Scholar 

  • LINDY, S., TURTO, H., and UITTO, J. (1972): Protocollagen proline hydroxylase activity in rat heart during experimental cardiac hypertrophy. Circ. Res. 30: 205–209.

    Google Scholar 

  • MARTIN, A.F., REDDY, M.K., ZAK, R., DOWELL, R.J. and RABINOWITZ, M. (1974): Protein metabolism in hypertrophied heart muscle. Circ. Res. (Suppl. III) 34 & 35: III 32–40.

    Google Scholar 

  • MCKEE, E.E., CHEUNG, J.Y., RANNELS, D.E. and MORGAN, H.E. (1978): Measurement of the rate of protein synthesis and compartment-ation of heart phenylalanine. J. Biol. Chem. 253: 1030–1040.

    Google Scholar 

  • MORGAN, H.E., EARL, D.C.N., BROADUS, A., WOLPERT, E.B., GIGER, K.E., and JEFFERSON, L.S. (1971): Regulation of protein synthesis in heart muscle. Effect of amino acid levels on protein synthesis. J. Biol. Chem. 246: 2152–2162.

    Google Scholar 

  • MORKIN, E., KIMATA, S., and SKILLMAN, J.J. (1972): Myosin synthesis and degradation during development of cardiac hypertrophy. Circ. Res. 30: 690–702.

    Google Scholar 

  • MOWBRAY, J. and LAST, K.S. (1974): Evidence against the incorporation into protein of amino acids directly from the membrane transport system in rat heart. Biochem. Biophys. Acta. 349: 4–122.

    Google Scholar 

  • Opie, L.H., Mansford, K.R.L. and Owen, P. (1971): Effects of increased heart work on glycolysis and adenine nucleotides in the perfused heart of normal and diabetic rats. Biochem. J. 124: 475–490.

    Google Scholar 

  • Oratz, M., Schreiber, S.S. and Rothschild, M.A. (1973): Study of albumin synthsis in relation to urea synthesis. Gastroenterology 65: 647–650.

    Google Scholar 

  • ORATZ, M., SCHREIBER, S.S. and ROTHSCHILD, M.A. (1977): Differing effects of synthesis. In Currents in Alcoholism. 1: 47–68. F. Seixas. (Ed.) Grune & Stratton, New York, N.Y.

    Google Scholar 

  • PAGE, E., POLIMENI, P.I., ZAK, R., EARLY, J. and JOHNSON, M. (1971): Myofibrillar mass in rat and rabbit muscle. Correlation of microchemical and stereological measurements in normal and hypertrophic hearts. Circ. Res. 30: 430–439.

    Google Scholar 

  • REGAN, T.J. and ETTINGER, P.O. (1979): Varied cardiac abnormalities in alcoholics. Clin. Exp. Res. 3: 40–50.

    Article  Google Scholar 

  • RAWAT, A.K. (1979): Inhibition of cardiac protein synthesis by prolonged ethanol administration. Res. Com. Chem. Pathol, and Pharmacol. 25: 89–102.

    Google Scholar 

  • RUBIN, E. (1979): Alcoholic myopathy in heart and skeletal muscle. N. Engl. J. Med. 301: 28–33.

    Article  Google Scholar 

  • SCHREIBER, S.S., ORATZ, M. and ROTHSCHILD, M.A. (1966): Protein synthesis in the overloaded mammalian heart. Am. J. Physiol. 211: 314–318.

    Google Scholar 

  • SCHREIBER, S.S., ORATZ, M., EVANS, C.D., SILVER, E. and ROTHSCHILD, M.A. (1968): Effect of acute overload on cardiac muscle mRNA. Am. J. Physiol. 215: 1250–1259.

    Google Scholar 

  • SCHREIBER, S.S., ORATZ, M. , EVANS, C.D., GUEYIKIAN, I. and ROTHSCHILD, M.A. (1970): Myosin myoglobin and collagen syntheses in acute cardiac overload. Am. J. Physiol. 219: 481–486.

    Google Scholar 

  • SCHREIBER, S.S. (1971): Initiation of protein synthesis in the acutely overloaded perfused heart. In Cardiac Hypertrophy” N. Alpert (Ed)., Academic Press, N.Y.

    Google Scholar 

  • SCHREIBER, S.S. and BRIDEN, K. (1972): Ethanol, acetaldehyde and myocardial protein synthesis. J. Clin. Invest. 51: 2820–2826.

    Article  Google Scholar 

  • SCHREIBER, S.S., ORATZ, M., EVANS, C.D., REFF, F., KLEIN, I. and ROTHSCHILD, M.A. (1973): Cardiac protein degradation in acute overload in vitro: Reutilization of amino acid. Am. J. Physiol. 224: 338–345.

    Google Scholar 

  • Schreiber, S.S., Oratz, M., Rothschild, M.A., Reff, F. and Evans, C (1974): Alcoholic cardiomyopathy II. The inhibition of cardiac microsomal protein synthesis by acetaldehyde. J. Mol. Cell. Cardiol. 6: 207–213.

    Article  Google Scholar 

  • SCHREIBER, S.S., ROTHSCHILD, M.A., EVANS, C.D., REFF, F., and ORATZ, M. (1975): The effect of pressure or flow stress on right ventricular protein synthesis in the face of constant and restricted coronary flow. J. Clin. Investig. 55: 1–11.

    Article  Google Scholar 

  • Schreiber, S.S., Hearse, D.J., Oratz, M. and Rothschild, M.A., (1977): Protein synthesis in prolonged cardiac arrest. J. Mol. Cell. Cardiol. 9: 87–100.

    Article  Google Scholar 

  • SCHREIBER, S.S., ORATZ, M., ROTHSCHILD, M.A. and REFF, F. (1978): The effect of hydrostatic pressure on isolated cardiac nuclei. Stimulation of RNA II polymerase activity. Cardiovasc. Res. 12: 265–268.

    Article  Google Scholar 

  • SCHREIBER, S.S., EVANS, C.D., ORATZ, M. and ROTHSCHILD, M.A. (1981): Protein synthesis and degradation in cardiac stress. Circ. Res. 48: 601–611.

    Google Scholar 

  • SEGEL, L.D., RENDIG, S.V. and MASON, D.T. (1979): Left ventricular dysfunction of isolated working rat hearts after chronic alcohol consumption. Cardiovasc. Res. 13: 136–146.

    Article  Google Scholar 

  • STEIN, T.P., LESKIW, M.J., BüZBY, G.P., GIandOMENICO, A.L., WALLACE, H.W. and MULLEN, J.L. (1980): Measurement of protein synthesis rats with 15N-glycine. Am. J. Physiol. 239: E294–E300.

    Google Scholar 

  • VIDRICH, A., AIRHART, J., BRUNO, M.K. and KHAIRALLAH, A. (1977): Compartmentation of free amino acids for protein biosynthesis. Biochem. J. 162: 257–266.

    Google Scholar 

  • WATKINS, C.A. and RANNELS, D.E. (1980): Measurements of protein synthesis in rat lungs perfused in situ. Biochem. J. 182: 269–278.

    Google Scholar 

  • WHITMAN, V., SCHULER, H.G. and MUSSELMAN, J. (1980): Effects of chronic ethanol consumption on the myocardial hypertrophic response to pressure overload in the rat. J. Mol. Cell. Cardiol. 12: 519–525.

    Article  Google Scholar 

  • WIKMAN-COFFELT, J., SELIS, R., FENNER, C. and MASON, D.T. (1973): Studies on the synthesis and degradation of light and heavy chains of myosin. J. Biol. Chem. 248: 5206–5207

    Google Scholar 

  • WILLIAMS, I.H., SUGDEN, P.H., and MORGAN, H.E. (1981): Use of aromatic amino acids as monitors of protein turnover. Am. J. Physiol. 240: E677–E681.

    Google Scholar 

  • ZAK, R., MARTIN, A.F., PRIOR, G., and RABINOWITZ, M. (1977): Comparison of turnover of several myofibrillar proteins and critical evaluation of double istope method. J. Biol. Chem. 252: 3430–3435.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Nuclear Medicine, Veterans Administration Medical Center, N.Y., USA

    Sidney S. Schreiber, Murray Oratz & Marcus A. Rothschild

  2. Department of Medicine, New York University School of Medicine, USA

    Sidney S. Schreiber, Murray Oratz & Marcus A. Rothschild

  3. Department of Biochemistry, New York University School of Dentistry, USA

    Sidney S. Schreiber, Murray Oratz & Marcus A. Rothschild

Authors
  1. Sidney S. Schreiber
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Murray Oratz
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Marcus A. Rothschild
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Sydney Hospital and Department of Medicine, University of Sydney, Sydney, Australia

    Leopold Dintenfass

  2. Freeman Hospital, University of Newcastle, Newcastle-upon-Tyne, England

    Desmond G. Julian

  3. The Oregon Health Sciences University, Portland, Oregon, USA

    Geoffrey V. F. Seaman

Rights and permissions

Reprints and permissions

Copyright information

© 1983 Plenum Press, New York

About this chapter

Cite this chapter

Schreiber, S.S., Oratz, M., Rothschild, M.A. (1983). Cardiac Protein Synthesis in Stress: Overload, Ethanol and Anoxia. In: Dintenfass, L., Julian, D.G., Seaman, G.V.F. (eds) Heart Perfusion, Energetics, and Ischemia. NATO Advanced Science Institutes Series, vol 62. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0393-1_17

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-0393-1_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-0395-5

  • Online ISBN: 978-1-4757-0393-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation