Abstract
In recent years an ever increasing set of cell surface and other markers has been used to classify and subclassify leukemic blast cells. Among these the socalled biochemical markers — mainly enzyme activities — have gained importance. One of these enzymes is terminal deoxynucleotidyl transferase but many enzymes of purine metabolism are also used (for a survey see Blatt et al1). 5′-Nucleotidase (5′-N) as an ectoenzyme has the double advantage of being testable by an ordinary enzyme assay on intact cells and at the same time being detectable by immunological methods as a surface structure. We have characterized leukemic cells using 5′-N not as an isolated marker but rather within a battery of other markers detectable by immunological means like specific antisera or rosetting assays.
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References
J. Blatt, G. Reaman and D.G. Poplack, Biochemical markers in lymphoid malignancy, New Engl.J.Med. 303: 918–922 (1980).
R. Silber, M. Conklyn, G. Grusky and D. Zucker-Franklin, Human lymphocytes: 5′-Nucleotidase-positive and-negative subpopulations, J.Clin.Invest. 56: 1324–1327 (1975).
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© 1984 Springer Science+Business Media New York
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Gutensohn, W., Thiel, E., Buschette, S. (1984). Ecto-5′-Nucleotidase as a Leukemia Marker. In: De Bruyn, C.H.M.M., Simmonds, H.A., Müller, M.M. (eds) Purine Metabolism in Man-IV. Advances in Experimental Medicine and Biology, vol 165. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0390-0_48
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DOI: https://doi.org/10.1007/978-1-4757-0390-0_48
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