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Purine Metabolism in Man-IV pp 99–106Cite as

Purine Metabolism in Human Thymocyte Subsets: Relevance for Lymphocytic Differentiation

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 165))

Abstract

The maturation pathway of the T lymphoid system, from (T) lymphopoietic precursor cell in the bone marrow via immature T lymphocytes in the thymus to mature immunocompetent T cells in peripheral organs and blood, is nowadays well established. Stages in T cell differentiation can be distinguished both by expression of cell surface and cytoplasmic differentiation markers (e.g., cell surface phenotyping with monoclonal antibodies to T lymphocyte (sub)populations1) and by functional capacity (e.g. differential responsiveness to mitogens like phytohaemagglutinin (PHA))2.

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References

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Author information

Authors and Affiliations

  1. Division of Immunopathology, University Hospital, Utrecht, The Netherlands

    H. J. Schuurman, R. Broekhuizen & P. Brekelmans

  2. Dept. of Human Genetics, Faculty of Medicine, University of Nijmegen, The Netherlands

    J. P. R. M. van Laarhoven, G. Th. Spierenburg & C. H. M. M. De Bruyn

  3. Dept. of Biophysics and Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

    C. G. Figdor

Authors
  1. H. J. Schuurman
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  2. J. P. R. M. van Laarhoven
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  3. R. Broekhuizen
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  4. P. Brekelmans
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  5. G. Th. Spierenburg
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  6. C. G. Figdor
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  7. C. H. M. M. De Bruyn
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Editor information

Editors and Affiliations

  1. University of Nijmegen Faculty of Medicine, Nijmegen, The Netherlands

    Chris H. M. M. De Bruyn

  2. Guy’s Hospital Medical School, London, UK

    H. Anne Simmonds

  3. University of Vienna, Vienna, Austria

    Mathias M. Müller

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© 1984 Springer Science+Business Media New York

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Schuurman, H.J. et al. (1984). Purine Metabolism in Human Thymocyte Subsets: Relevance for Lymphocytic Differentiation. In: De Bruyn, C.H.M.M., Simmonds, H.A., Müller, M.M. (eds) Purine Metabolism in Man-IV. Advances in Experimental Medicine and Biology, vol 165. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0390-0_21

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  • DOI: https://doi.org/10.1007/978-1-4757-0390-0_21

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-0392-4

  • Online ISBN: 978-1-4757-0390-0

  • eBook Packages: Springer Book Archive

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