Abstract
Lesions which remove the area postrema (AP) and the subjacent portions of the nucleus of the solitary tract (cmNTS) which lie in the caudal brainstem close to the dorsal spinomedullary junction cause dramatic and apparently permanent alterations in energy and fluid balance1,2. There is a well characterized syndrome of transient hypophagia and accompanying weight loss. Two to three weeks into this syndrome normophagia resumes with eventual stabilization of body weight but at a lower level. In addition there is a mild hyperdipsia. See figure 1.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
T. M. Hyde and R. R. Miselis, Effects of area postrema/caudal medial nucleus of the solitary tract lesions on food intake and body weight, Am. J. Physiol. 244:R577 (1983).
T. M. Hyde and R. R. Miselis, Area postrema and adjacent nucleus of the solitary tract in water and sodium balance, Am. J. Physiol. 247:R173 (1984).
R. Eng, R. E. Shapiro and R. R. Miselis, Vagal afferents to the area postrema/caudal medial nucleus of the solitary tract important for food intake and body weight: an HRP study, Neurosci. Abstr. 8: 273 (1982).
R. Norgren and G. P. Smith, The central distribution of vagal subdiagphragmatic branches in the rat, Neurosci. Abstr. 9: 611 (1983).
M. Kalia and M-M. Mesulam, Brain stem projections of sensory and motor components of the vagus complex in the cat: II. Laryngeal, tracheobronchial, pulmonary, cardiac and gastrointestinal branches, J. Comp. Neurol. 193: 467 (1980).
D. G. Gwyn, R. A. Leslie and D. A. Hopkins, Gastric afférents to the nucleus of the solitary tract in the cat, Neurosci. Lett. 14: 13 (1979).
R. E. Shapiro and R. R. Miselis, Organization of gastric efferent and afferent projections within the dorsal medulla ob-longatta in the rat, Anat. Rec. 205:182A (1983).
R. R. Miselis and R. E. Shapiro, Dorsal motor nucleus neurons have extensive dendrites penetrating the nucleus of the solitary tract, Fed. Proc. 42: 1125 (1983).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Springer Science+Business Media New York
About this chapter
Cite this chapter
Miselis, R.R., Hyde, T.M., Shapiro, R.E. (1986). Disturbances in Water Balance Controls Following Lesions to the Area Postrema and Adjacent Solitary Nucleus. In: de Caro, G., Epstein, A.N., Massi, M. (eds) The Physiology of Thirst and Sodium Appetite. NATO ASI Series, vol 105. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0366-5_36
Download citation
DOI: https://doi.org/10.1007/978-1-4757-0366-5_36
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-0368-9
Online ISBN: 978-1-4757-0366-5
eBook Packages: Springer Book Archive