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The Diabetic Pancreas pp 53–79Cite as

Growth Pattern of Pancreatic Islets in Animals

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Abstract

Since the first edition of The Diabetic Pancreas, new facts and observations relevant to islet growth have accumulated rapidly in the literature. Most of this concerns the B cell, but much new information has also been obtained on the other types of islet cells.* This progress, no doubt, reflects the more general use of immunocytochemical staining methods for identification of different islet cell types in combination with morphometric methods for quantitation of islet cell volume and weight. In addition, the application of techniques for cell cycle analyses has made possible a more detailed characterization of the various phases of B-cell life cycle. A review of these latter techniques will be given below. Animal experiments have furthermore expanded the knowledge on the effects of nutrients, hormones, and drugs on B-cell replication and they have contributed significant information on changes in islet cell proliferation with age. New animal models for both type I and type II diabetes have evolved and the role of a possible deficiency of B-cell proliferation for the manifestation of these diabetic syndromes has been a matter of much concern. It is the purpose of the present chapter to review and discuss the literature within this broad frame with particular emphasis on data that have appeared since the publication of the first edition in 1977.1

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References

  1. Hellerström, C.: In: The Diabetic Pancreas. Edited by B. W. Volk and K. F. Wellmann. Plenum Press, New York, 1977, p. 61.

    Chapter  Google Scholar 

  2. Orci, L., Baetens, D., Ravazzola, M., Stefan, Y., and Malaisse-Lagae, F.: Life Sci., 19:1811, 1976.

    Article  PubMed  CAS  Google Scholar 

  3. Orci, L., and Perrelet, A.: In: Glucagon. Edited by R. H. Unger and L. Orci. Elsevier, Amsterdam, 1981, p. 3.

    Google Scholar 

  4. Schauder, P., and Frerichs, H.: Diabetologia, 11:301, 1975.

    Article  PubMed  CAS  Google Scholar 

  5. Green, I. C., and Taylor, K. W.: J. Endocrinol, 54:317, 1972.

    Article  PubMed  CAS  Google Scholar 

  6. Beekman, J., Holze, S., Lenzen, S., and Panten, U.: Acta Diabetol Lat, 18:51, 1980.

    Article  Google Scholar 

  7. Hinegardner, R. T.: Anal. Biochem., 39:197, 1971.

    Article  PubMed  CAS  Google Scholar 

  8. Swenne, I., Bone, A. J., Howell, S. L., and Hellerström, C.: Diabetes, 29:686, 1980.

    PubMed  CAS  Google Scholar 

  9. Haugwitz, G. M.: Thesis, Ulm, 1972.

    Google Scholar 

  10. Pipeleers, D. G., and Pipeleers-Marichal, M. A.: Diabetologia, 20:654, 1981.

    Article  PubMed  CAS  Google Scholar 

  11. Van de Winkel, M., Maes, E., and Pipeleers, D.: Biochem. Biophys. Res. Commun., 107:525, 1982.

    Article  Google Scholar 

  12. Van de Winkel, M., and Pipeleers, D.: Biochem. Biophys. Res. Commun., 114:835, 1983.

    Article  Google Scholar 

  13. Nielsen, D. A., Lernmark A., Berelowitz, M., Bloom, G. D., and Steiner, D. F.: Diabetes, 31:299, 1982.

    Article  PubMed  CAS  Google Scholar 

  14. Rabinovitch, A., Rüssel, T., Shienvold, F., Noel, J., Files, N., Patel, Y., and Ingram, M.:Diabetes, 31:939, 1982.

    Article  PubMed  CAS  Google Scholar 

  15. Weibel, E. R., and Holender, R. P.: In: Principles and Techniques of Electron Microscopy. Edited by M. A. Hayat. Van Nostrand-Reinhold, Princeton, N.J., 1973.

    Google Scholar 

  16. Logothetopoulos, J.: In: Handbook of Physiology, Sect. 7, Vol. 1. Edited by D. F. Steiner and N. Freinkel. American Physiological Society, Washington, D.C., 1972, p. 67.

    Google Scholar 

  17. Swenne, I.: Thesis, Acta Universitatis Upsaliensis, 1981.

    Google Scholar 

  18. Swenne, I.: In: Methods in Diabetes Research, Part B, Vol. 1. Edited by S. L. Pohl and J. Lamer. John Wiley & Sons, New York, 1984, p. 175.

    Google Scholar 

  19. Howard, A., and Pelc, S. R.: Heredity, (Suppl. 6):261, 1953.

    CAS  Google Scholar 

  20. Quastler, H., and Sherman, F. G.: Exp. Cell Res., 17:420, 1959.

    Article  PubMed  CAS  Google Scholar 

  21. Bunnag, S. C.: Diabetes, 15:480, 1966.

    PubMed  CAS  Google Scholar 

  22. Swenne, I.: Diabetes, 31:754, 1982.

    PubMed  CAS  Google Scholar 

  23. Swenne, I.: Diabetes, 32:14, 1983.

    Article  PubMed  CAS  Google Scholar 

  24. Hellerström, C., Lewis, N., Borg, H., Johnson, R., and Freinkel, N.: Diabetes, 28:769, 1979.

    PubMed  Google Scholar 

  25. Dudek, R. W., Hellerström, C., Lewis, N. J., Johnson, R., and Freinkel, N.: Diabetes, 29:15, 1980.

    Article  PubMed  CAS  Google Scholar 

  26. Skoog, L., and Nordenskjöld, B.: Eur. J. Biochem., 19:81, 1971.

    Article  PubMed  CAS  Google Scholar 

  27. Wright, N. A., and Appleton, D. R.: Cell Tissue Kinet., 13:643, 1980.

    PubMed  CAS  Google Scholar 

  28. Swenne, I., and Eriksson, U.: Diabetologia, 23:525, 1982.

    Article  PubMed  CAS  Google Scholar 

  29. Pedersen, J.: The Pregnant Diabetic and Her Newborn, 2nd Ed. Munksgaard, Copenhagen, 1977.

    Google Scholar 

  30. Aynsley-Green, A.: In: Carbohydrate Metabolism and Its Disorders. Edited by P. J. Randle, D. F. Steiner, and W. J. Whelan. Academic Press, New York, 1981, p. 181.

    Google Scholar 

  31. Freie, H. M. P., Pasma, A., and Bouman, P. R.: Acta Endocrinol. (Copenhagen), 80:657, 1975.

    CAS  Google Scholar 

  32. McEvoy, R. C., and Madson, K. L.: Biol. Neonate, 38:248, 1980.

    Article  PubMed  CAS  Google Scholar 

  33. Eriksson, U., and Swenne, I.: Biol Neonate, 42:239, 1982.

    Article  PubMed  CAS  Google Scholar 

  34. Pictet, R., and Rutter, W. J.: In: Handbook of Physiology, Sect. 7, Vol. 1. Edited by D. F. Steiner and N. Freinkel. American Physiological Society, Washington, D. C., 1972, p. 25.

    Google Scholar 

  35. Cantenys, D., Portha, B., Dutrillaux, M. C., Hollande, E., Roze, C., and Picon, L.: Virchows Arch. B, 35:109, 1981.

    CAS  Google Scholar 

  36. Dutrillaux, M. C, Portha, B., Roze, C., and Hollande, E.: Virchows Arch. B, 39:173, 1982.

    Article  CAS  Google Scholar 

  37. Portha, B., Levacher, C., Picon, L., and Rosselin, G.: Diabetes, 23:889, 1974.

    PubMed  CAS  Google Scholar 

  38. Hultquist, G. T., Karisson, U., and Hallner, A. C: Exp. Pathol, 17:44, 1979.

    CAS  Google Scholar 

  39. Fujii, S.: Arch. Histol Jpn., 42:467, 1979.

    Article  PubMed  CAS  Google Scholar 

  40. Schweisthal, M. R., Frost, C. C., and Brinn, J. E.: Acta Diabetol Lat., 13:30, 1976.

    Article  PubMed  CAS  Google Scholar 

  41. Alumets, J., Sundler, F., and Häkanson, R.: Cell Tissue Res., 185:465, 1977.

    Article  PubMed  CAS  Google Scholar 

  42. Larsson, L.-L: Histochemistry, 54:133, 1977.

    Article  PubMed  CAS  Google Scholar 

  43. Dupouy, J. P., Chatelain, A., and Dubois, M. P.: Cell Tissue Res., 231:463, 1983.

    Article  PubMed  CAS  Google Scholar 

  44. Pictet, R., Clark, W. R., Renold, A. E., Williams, R. H., and Rutter, W. J.: J. Cell Biol, 39:105A, 1968.

    Google Scholar 

  45. Sundler, F., Häkanson, R., and Larsson, L.-L: Cell Tissue Res., 178:303, 1977.

    PubMed  CAS  Google Scholar 

  46. McEvoy, R. C, and Madson, K. L.: Biol Neonate, 38:255, 1980.

    Article  PubMed  CAS  Google Scholar 

  47. Eriksson, U., Andersson, A., Efendic, S., Eide, R., and Hellerström, C.: Acta Endocrinol (Copenhagen), 94:354, 1980.

    CAS  Google Scholar 

  48. Dubreuil, G., and Anderodias, J.: C. R. Soc. Biol, 83:1490, 1920.

    Google Scholar 

  49. Warren, S., LeCompte, P. M., and Legg, M. A.: The Pathology of Diabetes Mellitus, 4th Ed. Lea & Febiger, Philadelphia, 1966.

    Google Scholar 

  50. Hultquist, G. T., and Olding, L. B.: Acta Endocrinol (Copenhagen), 97(Suppl. 241):1, 1981.

    Google Scholar 

  51. Pedersen, J.: Acta Endocrinol (Copenhagen), 16:330, 1954.

    CAS  Google Scholar 

  52. Davis, M. E., Fugo, N. W., and Lawrence, K. G.: Proc. Soc. Exp. Biol Med, 66:638, 1947.

    PubMed  CAS  Google Scholar 

  53. Miller, H. C: Endocrinology, 40:251, 1947.

    Article  PubMed  CAS  Google Scholar 

  54. Shipley, E. G., and Danley, K. S.: Am. J. Physiol, 150:84, 1947.

    PubMed  CAS  Google Scholar 

  55. Levi, J. E., and Weinberg, T.: Proc. Soc. Exp. Biol. Med., 72:658, 1949.

    PubMed  CAS  Google Scholar 

  56. Sinden, J. A., and Longwell, B. B.: Proc. Soc. Exp. Biol. Med, 70:607, 1949.

    PubMed  CAS  Google Scholar 

  57. Ferret, P., Lindan, O., and Morgans, M. E.: J. Endocrinol., 7:100, 1950.

    Article  PubMed  CAS  Google Scholar 

  58. Hultquist, G. T.: Acta Pathol. Microbiol. Scand, 27:695, 1950.

    Article  Google Scholar 

  59. Lindan, O., and Morgans, M. E.: J. Endocrinol., 6:463, 1950.

    Article  Google Scholar 

  60. Bartelheimer, H., and Kloos, K.: Z. Gesamte Exp. Med, 119:246, 1952.

    Article  PubMed  CAS  Google Scholar 

  61. Nerenberger, S. T.: Arch. Pathol., 58:236, 1954.

    Google Scholar 

  62. Kim, J. N., Runge, W., Wells, L. J., and Lazarow, A.: Diabetes, 9:396, 1960.

    PubMed  CAS  Google Scholar 

  63. Lawrence, A. M., and Contopoulos, A. N.: Acta Endocrinol. (Copenhagen), 33:175, 1960.

    CAS  Google Scholar 

  64. Love, E. J., Kinch, R. A. H., and Stevenson, J. A. F.: Am. J. Obstet. Gynecol., 80:536, 1960.

    PubMed  CAS  Google Scholar 

  65. Koskenoja, M.: Acta Ophthalmol. Suppl., 68:1, 1961.

    PubMed  Google Scholar 

  66. Foglia, V. G., Chieri, R. A., and Cattaneo de Peralta Ramos, M.: Horm. Metab. Res., 2:76, 1970.

    Article  CAS  Google Scholar 

  67. Angervall, L.: Acta Endocrinol. (Copenhagen), 31(Suppl. 44): 1, 1959.

    CAS  Google Scholar 

  68. Solomon, F.: Diabetes, 8:45, 1959.

    PubMed  CAS  Google Scholar 

  69. Lazarow, A., Kim, J. N., and Wells, L. J.: Diabetes, 9:114, 1960.

    PubMed  CAS  Google Scholar 

  70. Baranov, V. G., and Sokoloverova, L M.: Opusc. Med, 13: 189, 1968.

    Google Scholar 

  71. Pitkin, R. M., Plank, C. J., and Filer, L. J., Jr.: Proc. Soc. Exp. Biol. Med, 138:163, 1971.

    PubMed  CAS  Google Scholar 

  72. Friedgood, C. E., and Miller, A. A.: Proc. Soc. Exp. Biol. Med, 59:61, 1945.

    CAS  Google Scholar 

  73. Rishi, S., Golob, E., and Becker, K. L.: Fed Proc., 28:708, 1969.

    Google Scholar 

  74. Golob, E. K., Rishi, S., Becker, K. L., and Moore, C.: Metabolism, 19:1014, 1970.

    Article  PubMed  CAS  Google Scholar 

  75. Sybulski, S., and Maughan, G. B.: Endocrinology, 89:1537, 1971.

    Article  PubMed  CAS  Google Scholar 

  76. Fujimoto, L, and Fujii, T.: Endocrinol. Jpn. 21:101, 1974.

    Article  PubMed  CAS  Google Scholar 

  77. Pitkin, R. M., and Van Orden, D. E.: Endocrinology, 94:1247, 1974.

    Article  PubMed  CAS  Google Scholar 

  78. Aerts, L., and Van Assche, F. A.: J. Endocrinol, 73:339, 1977.

    Article  PubMed  CAS  Google Scholar 

  79. Kervran, A., Guillaume, M., and Jost, A.: Diabetologia, 15:387, 1978.

    Article  PubMed  CAS  Google Scholar 

  80. de Gasparo, M., and Milner, R. D. G.: Diabetologia, 19:54, 1980.

    Article  PubMed  Google Scholar 

  81. Golob, E. K., Rishi, S., Becker, K. L., Moore, C., and Shah, N.: Diabetes, 19:610, 1970.

    PubMed  CAS  Google Scholar 

  82. Dixit, P. K., Lowe, L P., Heggestad, C. B., and Lazarow, A.: Diabetes, 13:71, 1964.

    PubMed  CAS  Google Scholar 

  83. Frye, B. E.:J Morphol, 101:325, 1957.

    Article  CAS  Google Scholar 

  84. Kim, J. N., Runge, W., Wells, L. J., and Lazarow, A.: Anat. Ree., 138:239, 1960.

    Article  CAS  Google Scholar 

  85. Eriksson, U.: Thesis, Acta Universitatis Upsaliensis, 1981.

    Google Scholar 

  86. Tydén, O., Berne, C, and Eriksson, U.: Pediatr. Res., 14:1192, 1980.

    Article  PubMed  Google Scholar 

  87. Eriksson, U., Hellerström, C., and Andersson, A.: Diabetes Metab., 7:243, 1981.

    CAS  Google Scholar 

  88. Eriksson, U., Dahlström, E., Larsson, K. S., and Hellerström, C.: Diabetes, 31:1, 1982.

    Article  PubMed  CAS  Google Scholar 

  89. Kim, Y. S., Jatoi, L, and Kim, Y.: Diabetologia, 18:407, 1980.

    PubMed  CAS  Google Scholar 

  90. Chez, R. A.: Diabetes Care, 3:435, 1980.

    PubMed  CAS  Google Scholar 

  91. Mintz, D. H., Chez, R. A., and Hutchinson, D. L.: J. Clin. Invest., 51:837, 1972.

    Article  PubMed  CAS  Google Scholar 

  92. Tejning, S.: Acta Med Scand, 128(Suppl. 198):1, 1947.

    Google Scholar 

  93. Wissler, R. W., Findley, J. W., and Frazier, L. E.: Proc. Soc. Exp. Biol Med, 71:308, 1949.

    PubMed  CAS  Google Scholar 

  94. Coleman, D., and Hummel, K. P.: Isr. J. Med Sci., 11:708, 1975.

    PubMed  CAS  Google Scholar 

  95. Denffer, H. von: Histochemie, 21:338, 1970.

    Article  CAS  Google Scholar 

  96. Davidson, M. B.: Metabolism, 28:688, 1979.

    Article  PubMed  CAS  Google Scholar 

  97. DeFronzo, R. A.: Diabetes Care, 4:493, 1981.

    Article  PubMed  CAS  Google Scholar 

  98. Olefsky, J. M., and Reaven, G. M.: Endocrinology, 96:1486, 1975.

    Article  PubMed  CAS  Google Scholar 

  99. Gold, G., Karoly, K., Freeman, C., and Adelman, R. C.: Biochem. Biophys. Res. Commun., 73:1003, 1976.

    Article  PubMed  CAS  Google Scholar 

  100. Reaven, E. P., Gold, G., and Reaven, G. M.: J. Clin. Invest, 64:591, 1979.

    Article  PubMed  CAS  Google Scholar 

  101. Remade, C., Hauser, N., Jeanjean, M., and Gommers, A.: Exp. Gerontol, 12:207, 1977.

    Article  Google Scholar 

  102. Remade, C., DeClercq, L., Delaère, P., Many, M.-C, and Gommers, A.: Cell Tissue Res., 207:429, 1980.

    Google Scholar 

  103. DeClercq, L., Schmidt, G., Delaère, P., and Remade, C: Cell Biol Int. Rep. 4:817, 1980.

    Article  CAS  Google Scholar 

  104. McEvoy, R. C: Diabetes, 30:813, 1981.

    Article  PubMed  CAS  Google Scholar 

  105. Hdlman, B.: Acta Pathol Microbiol Scand, 47:35, 1959.

    Google Scholar 

  106. Gelfant, S., and Smith, J. G.: Science, 178:357, 1972.

    Article  PubMed  CAS  Google Scholar 

  107. Hellerström, C: Acta Soc. Med. Ups., 68:17, 1963.

    Google Scholar 

  108. Green, J. C., El Seifi, S., Perrin, D., and Howell, S. L.: J. Endocrinol, 88:219, 1981.

    Article  PubMed  CAS  Google Scholar 

  109. Petersson, B., and Hellman, B.: Metabolism, 11:342, 1962.

    PubMed  CAS  Google Scholar 

  110. Klöppel, G., Drenck, C. P., Habich, K., Bommer, G., and Heitz, P. U.: Diabetologia, 25:171, 1983.

    Google Scholar 

  111. Chick, W. L., Lauris, V., Flewelling, J. H., Andrews, K. A., and Woodruff, J. M.: Endocrinology, 92:212, 1973.

    Article  PubMed  CAS  Google Scholar 

  112. Chick, W. L.: Diabetes, 22:687, 1973.

    PubMed  CAS  Google Scholar 

  113. Andersson, A.: Endocrinology, 96:1051, 1973.

    Article  Google Scholar 

  114. King, D. L., and Chick, W. L.: Endocrinology, 99:1003, 1976.

    Article  PubMed  CAS  Google Scholar 

  115. King, D. L., Chick, W. L., and Kitchen, K. C.: In: Pancreatic Beta Cell Culture. Edited by E. von Wasielewski and W. L. Chick. Excerpta Medica, Amsterdam, 1977, p. 109.

    Google Scholar 

  116. King, D. L., Kitchen, D. C., and Chick, W. L.: Endocrinology, 103:1321, 1978.

    Article  PubMed  CAS  Google Scholar 

  117. de Gasparo, M. Milner, G. R., Norris, P. D., and Milner, R. D. G.: J. Endocrinol, 77:241, 1978.

    Article  PubMed  Google Scholar 

  118. Ono, J., Takaki, R., Okano, H., and Fukama, M.: In Vitro, 15:95, 1979.

    Article  CAS  Google Scholar 

  119. Kasai, M., Ikeuchi, M., Kanazawa, Y., and Kosaka, K.: Biomed. Res., 3:688, 1982.

    CAS  Google Scholar 

  120. Kaung, H. L. C.: Embryol Exp. Morphol, 74:303, 1983.

    Google Scholar 

  121. Rabinovitch, A., Blondel, B., Murray, T., and Mintz, D.: J. Clin. Invest., 66:1065, 1980.

    Article  PubMed  CAS  Google Scholar 

  122. Swenne, I.: Biosci. Rep., 2:867, 1982.

    Article  PubMed  CAS  Google Scholar 

  123. Hellerström, C., and Brolin, S. E.: In: Handbook of Experimental Pharmacology, New Series, Vol. 32/2. Edited by A. Hasselblatt and F. von Bruchhausen. Springer-Verlag, Berlin, 1975, p. 57.

    Google Scholar 

  124. Pastan, I. H., Johnson, G. S., and Anderson, W. B.: Annu. Rev. Biochem., 44:491, 1975.

    Article  PubMed  CAS  Google Scholar 

  125. Rabinovitch, A., Quigley, C., and Rechler, M.: Diabetes, 32:307, 1983.

    Article  PubMed  CAS  Google Scholar 

  126. McEvoy, R. C: Horm. Metab. Res., 13:5, 1981.

    Article  CAS  Google Scholar 

  127. Rabinovitch, A., Quigley, C., Russel, T., Patel, Y., and Mintz, D.: Diabetes, 31:160, 1982.

    Article  PubMed  CAS  Google Scholar 

  128. Höiriis Nielsen, J.: Endocrinology, 110:600, 1982.

    Article  Google Scholar 

  129. Parsons, J. A., Harfel, M. A., Hegre, O. D., and McEvoy, R. C: Diabetes, 32:67, 1983.

    Article  PubMed  CAS  Google Scholar 

  130. Cornblath, M., Parker, M. L., Reisner, S. H., Forbes, A. E., and Daughaday, W. H.: Clin. Endocrinol Metab., 25:209, 1965.

    Article  CAS  Google Scholar 

  131. Luft, R., Cerasi, E., and Hamberger, C. A.: Acta Endocrinol (Copenhagen), 45:593, 1967.

    Google Scholar 

  132. Aragona, C., and Friesen, H. G.: In: Endocrinology, Vol. 3. Edited by L. J. DeGroot, G. F. Cahill, W. D. Odell, L. Martini, J. T. Potts, D. H. Nelson, E. Steinberger, and A. I. Winegrad. Grune & Stratton, New York, 1979, p. 1613.

    Google Scholar 

  133. McEvoy, R. C., Lazarow, A., and Hegre, O. D.: Differentiation, 3:69, 1975.

    Article  PubMed  CAS  Google Scholar 

  134. McEvoy, R. C., Hegre, O. D., and Lazarow, A.: Differentiation, 6:17, 1976.

    Article  PubMed  CAS  Google Scholar 

  135. McEvoy, R. C, and Hegre, O. D.: Differentiation, 6:105, 1976.

    Article  PubMed  CAS  Google Scholar 

  136. McEvoy, R. C: Am. J. Anat., 157:319, 1980.

    Article  PubMed  CAS  Google Scholar 

  137. McEvoy, R. C, Leung, P. E., and Goggins, J. A.: Endocrinology, 108:2277, 1981.

    Article  PubMed  CAS  Google Scholar 

  138. Clark, A., Bown, E., King, T., Vanhegan, R. J., and Turner, R. C.: Diabetes, 31:319, 1982.

    Article  PubMed  CAS  Google Scholar 

  139. Sir El-Khatim, M.: Personal communication.

    Google Scholar 

  140. Hii, C. S. T., and Howell, S. L.: Diabetes, 33:291, 1984.

    Article  PubMed  CAS  Google Scholar 

  141. McEvoy, R. C: Differentiation, 17:105, 1980.

    Article  PubMed  CAS  Google Scholar 

  142. McEvoy, R. C, and Leung, P. E.: Endocrinology, 111:1568, 1982.

    Article  PubMed  CAS  Google Scholar 

  143. Swenne, I., and Bone, A. J.: Cell Biol Int. Rep., 5:647, 1981.

    Article  PubMed  CAS  Google Scholar 

  144. Pace, C. S., and Clements, R. S.: Diabetes, 30:621, 1981.

    Article  PubMed  CAS  Google Scholar 

  145. Fong, H. K. W., Chick, W. L., and Sato, G. H.: Diabetes, 30:1022, 1981.

    Article  PubMed  CAS  Google Scholar 

  146. Bonner-Weir, S., Trent, D. F., and Weir, G. C.: J. Clin. Invest., 71:1544, 1983.

    Article  PubMed  CAS  Google Scholar 

  147. Boquist, L.: Virchows Arch. B, 1:169, 1968.

    Google Scholar 

  148. Jacob, S.: Cell Tissue Res., 181:277, 1977.

    Article  PubMed  CAS  Google Scholar 

  149. Johnson, D. D.: Endocrinology, 47:393, 1950.

    Article  PubMed  CAS  Google Scholar 

  150. Ziegler, B., Noack, S., Diaz-Alonso, J. M., and Hahn, H. J.: Diabetologia, 25:160, 1983.

    Google Scholar 

  151. McEvoy, R. C, and Hegre, O. D.: Diabetes, 26:1140, 1977.

    Article  PubMed  CAS  Google Scholar 

  152. Hellman, B., and Petersson, B.: Endocrinology, 72:238, 1963.

    Article  PubMed  CAS  Google Scholar 

  153. Orci, L., Baetens, D., Rufener, C., Amherdt, M., Ravazzola, M., Studer, P., Malaisse-Lagae, F., and Unger, R. H.: Proc. Natl Acad Sci USA, 73:1338, 1976.

    Article  PubMed  CAS  Google Scholar 

  154. Coleman, D. L.: Diabetologia, 14:141, 1978.

    Article  PubMed  CAS  Google Scholar 

  155. Leiter, E. H., Coleman, D. L., and Hummel, K. P.: Diabetes, 30:1029, 1981.

    Article  PubMed  CAS  Google Scholar 

  156. Leiter, E. H.: Diabetes, 30:1035, 1981.

    Article  PubMed  CAS  Google Scholar 

  157. Coleman, D. L., and Hummel, K. P.: Diabetologia, 9:287, 1973.

    Article  PubMed  CAS  Google Scholar 

  158. Coleman, D. L., Leiter, E. H., and Schwiger, R. W.: Diabetes, 31:830, 1982.

    Article  PubMed  CAS  Google Scholar 

  159. Leiter, E. H., Coleman, D. L., Eisenstein, A. B., and Strack, L: Metabolism, 30:554, 1981.

    Article  PubMed  CAS  Google Scholar 

  160. Leiter, E. H., Coleman, D. L., Ingram, D. K., and Reynolds, M. A.: J. Nutr., 113:184, 1983.

    PubMed  CAS  Google Scholar 

  161. Swenne, L, and Andersson, A.: Diabetologia, 25:197, 1983.

    Google Scholar 

  162. Leiter, E. H., Coleman, D. L., Eisenstein, A. B., and Strack, L: Diabetologia, 19:58, 1980.

    Article  PubMed  CAS  Google Scholar 

  163. Baetens, D., Stefan, Y., Ravazzola, M., Malaisse-Lagae, F., Coleman, D. L., and Orci, L.: Diabetes, 27:1, 1978.

    Article  PubMed  CAS  Google Scholar 

  164. Leiter, E. H., Gapp, D. A., Eppig, J. J., and Coleman, D. L.: Diabetologia, 17:297, 1979.

    Article  PubMed  CAS  Google Scholar 

  165. Dolais-Kitabgi, J., Le Marchand-Brustel, Y., and Freychet, P.: Diabetologia, 17:257, 1979.

    Article  PubMed  CAS  Google Scholar 

  166. Gingerich, R. L., Gersell, D. J., Greider, M. H., Finke, E. H., and Lacy, P. E.: Metabolism, 27:1526, 1978.

    Article  PubMed  CAS  Google Scholar 

  167. Petersson, B., Eide, R., Efendic, S., Hökfelt, T., Johansson, O., Luft, R., Cerasi, E., and Hellerström, C.: Diabetologia, 13:463, 1977.

    Article  PubMed  CAS  Google Scholar 

  168. Lazarow, A., Wells, L. J., Carpenter, A. M., Hegre, O. D., Leonard, R. J., and McEvoy, R. C.: Diabetes, 22:827, 1973.

    Google Scholar 

  169. Hegre, O. D., Leonard, R. J., and Lazarow, A.: Anat. Ree., 185:209, 1976.

    Article  CAS  Google Scholar 

  170. Hegre, O. D., McEvoy, R. C., and Schmitt, R. V.: In: Pancreatic Beta Cell Culture. Edited by E. von Wasielewski and W. L. Chick. Excerpta Medica, Amsterdam, 1977, p. 71.

    Google Scholar 

  171. McEvoy, R. C., Schmitt, R. V., and Hegre, O. D.: Diabetes, 27:982, 1978.

    Article  PubMed  CAS  Google Scholar 

  172. McEvoy, R. C, and Hegre, O. D.: Diabetes, 27:988, 1978.

    Article  PubMed  CAS  Google Scholar 

  173. McEvoy, R. C, and Hegre, O. D.: Diabetes, 28:141, 1979.

    Article  PubMed  CAS  Google Scholar 

  174. Mullen, Y. S., Clark, W. R., Molnar, I. G., and Brown, J.: Science, 195:68, 1977.

    Article  PubMed  CAS  Google Scholar 

  175. Brown, J., Heininger, D., Kuret, J., and Mullen, Y.: Diabetes, 30:9, 1981.

    PubMed  CAS  Google Scholar 

  176. Hoffman, L., Mandel, T. E., and Carter, W.: Diabetes, 31:826, 1982.

    PubMed  CAS  Google Scholar 

  177. Andersson, A., Eriksson, U., Petersson, B., Reibring, L., and Swenne, I.: Diabetologia, 20:237, 1981.

    Article  PubMed  CAS  Google Scholar 

  178. Andersson, A.: Diabetologia, 25:269, 1983.

    Article  PubMed  CAS  Google Scholar 

  179. Westermark, P., and Wilander, E.: Diabetologia, 15:417, 1978.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Medical Cell Biology, University of Uppsala, S-75123, Uppsala, Sweden

    Claes Hellerström & Ingemar Swenne

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  1. Claes Hellerström
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  2. Ingemar Swenne
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Editors and Affiliations

  1. University of California Irvine Medical Center, Orange, California, USA

    Bruno W. Volk M.D.  & Edward R. Arquilla M.D., Ph.D.  & 

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© 1985 Plenum Publishing Corporation

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Hellerström, C., Swenne, I. (1985). Growth Pattern of Pancreatic Islets in Animals. In: Volk, B.W., Arquilla, E.R. (eds) The Diabetic Pancreas. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0348-1_3

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  • DOI: https://doi.org/10.1007/978-1-4757-0348-1_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-0350-4

  • Online ISBN: 978-1-4757-0348-1

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